Search Results - "Clark, Kenzie A."

Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif by Bushin, Leah B, Clark, Kenzie A, Pelczer, István, Seyedsayamdost, Mohammad R

“…Peptide natural products are often used as signals or antibiotics and contain unusual structural modifications, thus providing opportunities for expanding our…”
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Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis by Clark, Kenzie A, Bushin, Leah B, Seyedsayamdost, Mohammad R

“…The biosynthetic pathways of microbial natural products provide a rich source of novel enzyme-catalyzed transformations. Using a new bioinformatic search…”
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Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine–Tryptophan Crosslink by Clark, Kenzie A., Seyedsayamdost, Mohammad R.

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of natural products with diverse activities and structures…”
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Radical Approach to Enzymatic β‑Thioether Bond Formation by Caruso, Alessio, Bushin, Leah B, Clark, Kenzie A, Martinie, Ryan J, Seyedsayamdost, Mohammad R

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emerging class of natural products that harbor diverse chemical…”
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Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine by Clark, Kenzie A., Covington, Brett C., Seyedsayamdost, Mohammad R.

“…The combination of next-generation DNA sequencing technologies and bioinformatics has revitalized natural product discovery. Using a bioinformatic search…”
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Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs by Bushin, Leah B., Covington, Brett C., Clark, Kenzie A., Caruso, Alessio, Seyedsayamdost, Mohammad R.

“…Microbial natural products comprise diverse architectures that are generated by equally diverse biosynthetic strategies. In peptide natural products, amino…”
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N–Cα Bond Cleavage Catalyzed by a Multinuclear Iron Oxygenase from a Divergent Methanobactin-like RiPP Gene Cluster by Chioti, Vasiliki T., Clark, Kenzie A., Ganley, Jack G., Han, Esther J., Seyedsayamdost, Mohammad R.

“…DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes involved in the biosynthesis of ribosomally synthesized and…”
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Expanding the Landscape of Noncanonical Amino Acids in RiPP Biosynthesis by Johnson, Brooke A., Clark, Kenzie A., Bushin, Leah B., Spolar, Calvin N., Seyedsayamdost, Mohammad R.

“…Advancements in DNA sequencing technologies and bioinformatics have enabled the discovery of new metabolic reactions from overlooked microbial species and…”
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RaS-RiPPs in Streptococci and the Human Microbiome by Clark, Kenzie A., Bushin, Leah B., Seyedsayamdost, Mohammad R.

“…Radical S-adenosylmethionine (RaS) enzymes have quickly advanced to one of the most abundant and versatile enzyme superfamilies known. Their chemistry is…”
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Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile by Cruite, Justin T., Kovacikova, Gabriela, Clark, Kenzie A., Woodbrey, Anne K., Skorupski, Karen, Kull, F. Jon

“…The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae , the gram-negative bacterial pathogen that causes the…”
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A bipartite network approach to inferring interactions between environmental exposures and human diseases by Darabos, Christian, Grussing, Emily D, Cricco, Maria E, Clark, Kenzie A, Moore, Jason H

“…Environmental exposure is a key factor of understanding health and diseases. Beyond genetic propensities, many disorders are, in part, caused by human…”
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Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile by Cruite, Justin T, Kovacikova, Gabriela, Clark, Kenzie A, Woodbrey, Anne K, Skorupski, Karen, Kull, F Jon

“…The AraC/XylS-family transcriptional regulator ToxT is the master virulence activator of Vibrio cholerae, the gram-negative bacterial pathogen that causes the…”
Get full text