Search Results - "Clark, John K"

High-resolution forest carbon stocks and emissions in the Amazon by Asner, Gregory P., Powell, George V. N., Mascaro, Joseph, Knapp, David E., Clark, John K., Jacobson, James, Kennedy-Bowdoin, Ty, Balaji, Aravindh, Paez-Acosta, Guayana, Victoria, Eloy, Secada, Laura, Valqui, Michael, Hughes, R. Flint

“…Efforts to mitigate climate change through the Reduced Emissions from Deforestation and Degradation (REDD) depend on mapping and monitoring of tropical forest…”
Get full text

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide:  Synthesis and Structure−Activity Relationships by Adam, Julia M, Bennett, D. Jonathan, Bom, Anton, Clark, John K, Feilden, Helen, Hutchinson, Edward J, Palin, Ronald, Prosser, Alan, Rees, David C, Rosair, Georgina M, Stevenson, Donald, Tarver, Gary J, Zhang, Ming-Qiang

“…A series of mono- and per-6-substituted cyclodextrin derivatives were synthesized as synthetic receptors (or host molecules) of rocuronium bromide, the most…”
Get full text

Human and environmental controls over aboveground carbon storage in Madagascar by Asner, Gregory P, Clark, John K, Mascaro, Joseph, Vaudry, Romuald, Chadwick, K Dana, Vieilledent, Ghislain, Rasamoelina, Maminiaina, Balaji, Aravindh, Kennedy-Bowdoin, Ty, Maatoug, Léna, Colgan, Matthew S, Knapp, David E

“…Background Accurate, high-resolution mapping of aboveground carbon density (ACD, Mg C ha -1 ) could provide insight into human and environmental controls over…”
Get full text

Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain by Adam, Julia M., Clark, John K., Davies, Keneth, Everett, Kathryn, Fields, Ruth, Francis, Stuart, Jeremiah, Fiona, Kiyoi, Takao, Maidment, Maurice, Morrison, Angus, Ratcliffe, Paul, Prosser, Alan, Schulz, Jurgen, Wishart, Grant, Baker, James, Boyce, Susan, Campbell, Robert, Cottney, Jean E., Deehan, Maureen, Martin, Iain

“…Novel, low brain penetrant, orally bioavailable CB1 receptor agonists were designed using calculated polar surface area as a predictor of CNS permeability…”
Get full text

High-resolution carbon mapping on the million-hectare Island of Hawaii by Asner, Gregory P, Hughes, R Flint, Mascaro, Joseph, Uowolo, Amanda L, Knapp, David E, Jacobson, James, Kennedy-Bowdoin, Ty, Clark, John K

“…Current markets and international agreements for reducing emissions from deforestation and forest degradation (REDD) rely on carbon (C) monitoring techniques…”
Get full text

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host by Bom, Anton, Bradley, Mark, Cameron, Ken, Clark, John K., van Egmond, Jan, Feilden, Helen, MacLean, Elizabeth J., Muir, Alan W., Palin, Ronald, Rees, David C., Zhang, Ming-Qiang

“…Superior to current clinically used reversal agents in terms of efficacy and side effects: The formation of a high‐affinity host–guest binary complex…”
Get full text

Reply to Skole et al.: Regarding high-resolution carbon stocks and emissions in the Amazon by Asner, Gregory P., Mascaro, Joseph, Clark, John K., Powell, George

Get full text

Design, synthesis, and structure–activity relationships of indole-3-heterocycles as agonists of the CB1 receptor by Morrison, Angus J., Adam, Julia M., Baker, James A., Campbell, Robert A., Clark, John K., Cottney, Jean E., Deehan, Maureen, Easson, Anna-Marie, Fields, Ruth, Francis, Stuart, Jeremiah, Fiona, Keddie, Neil, Kiyoi, Takao, McArthur, Duncan R., Meyer, Karsten, Ratcliffe, Paul D., Schulz, Jurgen, Wishart, Grant, Yoshiizumi, Kazuya

“…Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a…”
Get full text

Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties by Palin, Ronald, Clark, John K., Evans, Louise, Houghton, Andrea K., Jones, Philip S., Prosser, Alan, Wishart, Grant, Yoshiizumi, Kazuya

“…The N-3 position of a series of 3-phenoxypropyl piperidine benzimidazol-2-one analogues was optimised using the predictive power of a CoMFA model. The model…”
Get full text

The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists by Cowley, Phillip M., Baker, James, Barn, David R., Buchanan, Kirsteen I., Carlyle, Ian, Clark, John K., Clarkson, Thomas R., Deehan, Maureen, Edwards, Darren, Goodwin, Richard R., Jaap, David, Kiyoi, Yasuko, Mort, Chris, Palin, Ronald, Prosser, Alan, Walker, Glenn, Ward, Nick, Wishart, Grant, Young, Trevor

“…The discovery and structure–activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound…”
Get full text

Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists by Kiyoi, Takao, Adam, Julia M., Clark, John K., Davies, Keneth, Easson, Anna-Marie, Edwards, Darren, Feilden, Helen, Fields, Ruth, Francis, Stuart, Jeremiah, Fiona, McArthur, Duncan, Morrison, Angus J., Prosser, Alan, Ratcliffe, Paul D., Schulz, Jurgen, Wishart, Grant, Baker, James, Campbell, Robert, Cottney, Jean E., Deehan, Maureen, Epemolu, Ola, Evans, Louise

“…Novel 3-(1 H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent CB1 cannabinoid receptor agonists. The oral…”
Get full text

Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB₁ antagonists by Cowley, Phillip M, Baker, James, Buchanan, Kirsteen I, Carlyle, Ian, Clark, John K, Clarkson, Thomas R, Deehan, Maureen, Edwards, Darren, Kiyoi, Yasuko, Martin, Iain, Osbourn, Dawn, Walker, Glenn, Ward, Nick, Wishart, Grant

“…The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB₁ receptor is disclosed. Compound 24 was…”
Get full text

Design, synthesis and structure–activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate by Ratcliffe, Paul, Adam, Julia M., Baker, James, Bursi, Roberta, Campbell, Robert, Clark, John K., Cottney, Jean E., Deehan, Maureen, Easson, Anna-Marie, Ecker, Daniel, Edwards, Darren, Epemolu, Ola, Evans, Louise, Fields, Ruth, Francis, Stuart, Harradine, Paul, Jeremiah, Fiona, Kiyoi, Takao, McArthur, Duncan, Morrison, Angus, Passier, Paul, Pick, Jack, Schnabel, Peter G., Schulz, Jurgen, Steinbrede, Heinz, Walker, Glenn, Westwood, Paul, Wishart, Grant, Haes, Joanna Udo de

“…We report an expansion of the structure–activity relationship (SAR) of a novel series of indole-3-heterocyclic CB1 receptor agonists. Starting from the potent…”
Get full text

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties by Palin, Ronald, Bom, Anton, Clark, John K., Evans, Louise, Feilden, Helen, Houghton, Andrea K., Jones, Philip S., Montgomery, Brian, Weston, Mark A., Wishart, Grant

“…A series of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues were prepared and evaluated as NOP agonists. The selective NOP agonist (+)-…”
Get full text

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach by Palin, Ronald, Clark, John K., Evans, Louise, Feilden, Helen, Fletcher, Dan, Hamilton, Niall M., Houghton, Andrea K., Jones, Philip S., McArthur, Duncan, Montgomery, Brian, Ratcliffe, Paul D., Smith, Alasdair R.C., Sutherland, Aaron, Weston, Mark A., Wishart, Grant

“…A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one…”
Get full text

Novel Piperidinium and Pyridinium Agents as Water-Soluble Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Blockade by Palin, Ronald, Clark, John K., Cowley, Phill, Muir, Alan W., Pow, Eleanor, Prosser, Alan B., Taylor, Robert, Zhang, Ming-Qiang

“…The synthesis of novel pyridinium salts as powerful acetylcholinesterase inhibitors with improved water solubility is reported, for example 43 (IC 50=0.007 μM,…”
Get full text

Quaternary Salts of E2020 Analogues as Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Block by Clark, John K, Cowley, Phill, Muir, Alan W, Palin, Ronald, Pow, Eleanor, Prosser, Alan B, Taylor, Robert, Zhang, Ming-Qiang

“…A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of…”
Get full text

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists by Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

“…A series of potent and soluble ORL1 agonists was prepared and evaluated. Compound 41 showed antinociceptive properties in mouse formalin paw test (ED 50 = 1.07…”
Get full text

Non-depolarizing Neuromuscular Blocking Activity of Bisquaternary Amino Di- and Tripeptide Derivatives by Booij, Leo H. D. J, van der Broek, Leon A. G. M, Caulfield, Wilson, Dommerholt-Caris, Brigitte M. G, Clark, John K, van Egmond, Jan, McGuire, Ross, Muir, Alan W, Ottenheijm, Harry C. J, Rees, David C

“…Herein we describe the synthesis of novel di- and tripeptide derivatives with two quaternary nitrogen groups attached and the biological testing of these…”
Get full text

A Molecular Chameleon:  Chair and Twist-Boat Conformations of a 5,9-Methanobenzo[8]annulene by Fielding, Lee, Clark, John K, McGuire, Ross

“…A molecule that can change shape to suit its environment (a “molecular chameleon”) is described. In solution there is an equilibrium between a compact chair…”
Get full text