Search Results - "Clark, Janet A."

Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus by Clark, Janet A., Pai, Lee-Yuh, Flick, Rosemarie Beth, Rohrer, Susan P.

“…Recently a novel tryptophan hydroxylase isoform (TPH2) was identified and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on…”
Get full text

Distribution of the GABAB receptor subunit gb2 in rat CNS by CLARK, J. A, MEZEY, E, LAM, A. S, BONNER, T. I

Get full text

The ASPET Mentoring Network: Enhancing Diversity and Inclusion through Career Coaching Groups within a Scientific Society by Womack, Veronica Y, Thakore, Bhoomi K, Wood, Christine V, Jewett, David C, Jones, Remi F, Ingram, Susan L, Clark, Janet A, Fry, Catherine L, Wecker, Lynn, McGee, Richard

“…Over the past decades, two persisting priorities in science, technology, engineering, and mathematics (STEM) training have been: (1) increasing the knowledge…”
Get full text

A depressive phenotype induced by Bacille Calmette Guérin in ‘susceptible’ animals: sensitivity to antidepressants by Platt, Brian, Schulenberg, Janet, Klee, Nicole, Nizami, Maryam, Clark, Janet A.

“…Rationale The depressive phenotype in the BCG model of chronic inflammation has not been pharmacologically characterized. Objectives This study aims to…”
Get full text

Estrogen receptor-β regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe by Gundlah, Chrisana, Alves, Stephen E., Clark, Janet A., Pai, Lee-Yuh, Schaeffer, James M., Rohrer, Susan P.

“…Distinct expression patterns of estrogen receptor (ER)-α and ER-β are displayed in the murine central nervous system. ER-β is the predominant form of the…”
Get full text

Modeling an Inflammation-Related Depressive Phenotype in Mice Using Bacille Calmette-Guérin by Platt, Brian J, Clark, Janet A

“…The relationship between inflammation and neuropsychiatric symptoms is of interest to the scientific community for several reasons. A substantial subset of…”
Get more information

Amino acid neurotransmitter transporters: structure, function, and molecular diversity by Clark, J A, Amara, S G

“…Many biologically active compounds including neurotransmitters, metabolic precursors, and certain drugs are accumulated intracellularly by transporters that…”
Get more information

Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity by Hoare, S R, Clark, J A, Usdin, T B

“…Tuberoinfundibular peptide of 39 residues (TIP39) and the parathyroid hormone-2 (PTH2) receptor form part of an extended family of related signaling molecules…”
Get full text

Analysis of the Transmembrane Topology and Membrane Assembly of the GAT-1 γ-Aminobutyric Acid Transporter by Janet A. Clark

“…The transmembrane topology of the Na + - and Cl − -dependent γ-aminobutyric acid transporter GAT-1 has been studied using protein chimeras in Xenopus…”
Get full text

Analysis of the transmembrane topology and membrane assembly of the GAT-1 gamma-aminobutyric acid transporter by Clark, J A

“…The transmembrane topology of the Na+- and Cl--dependent gamma-aminobutyric acid transporter GAT-1 has been studied using protein chimeras in Xenopus oocytes…”
Get full text

Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter by Clark, J A, Deutch, A Y, Gallipoli, P Z, Amara, S G

“…The synaptic action of gamma-aminobutyric acid (GABA) is terminated by high affinity, Na(+)-dependent transport processes in both neurons and glia. We have…”
Get more information

Molecular Determinants of Tuberoinfundibular Peptide of 39 Residues (TIP39) Selectivity for the Parathyroid Hormone-2 (PTH2) Receptor by Sam R. J. Hoare, Janet A. Clark, Ted B. Usdin

“…Tuberoinfundibular peptide of 39 residues (TIP39) and the parathyroid hormone-2 (PTH2) receptor form part of an extended family of related signaling molecules…”
Get full text

Molecular Determinants of Tuberoinfundibular Peptide of 39 Residues (TIP39) Selectivity for the Parathyroid Hormone-2 (PTH2) Receptor by Hoare, Sam R.J., Clark, Janet A., Usdin, Ted B.

Get full text

Analysis of transporter topology using deletion and epitope tagging by Clark, J A

Get more information

Vaccinia-T7 RNA polymerase expression system: evaluation for the expression cloning of plasma membrane transporters by Blakely, R D, Clark, J A, Rudnick, G, Amara, S G

“…The vaccinia/T7 transient expression system, which results in rapid, high-level expression of proteins encoded by plasmids bearing T7 promoters, provides a…”
Get more information

Stable expression of a neuronal gamma-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence by Clark, J A, Amara, S G

“…The transport proteins that mediate gamma-aminobutyric acid (GABA) reuptake have been major targets for the development of agents to treat neurological…”
Get more information

Morphine-6-glucuronide, a potent mu agonist by Pasternak, G W, Bodnar, R J, Clark, J A, Inturrisi, C E

“…The 3- and the 6-glucuronides of morphine have been examined in binding studies and in vivo. The 3-glucuronide had poor affinity in all binding studies whereas…”
Get more information

Distribution of the GABA B receptor subunit gb2 in rat CNS by Clark, Janet A, Mezey, Éva, Lam, Alan S, Bonner, Tom I

“…We have identified and isolated human and rat cDNAs for a novel receptor, gb2, with 38% homology to the GABA B receptors gb1a and gb1b. These receptors…”
Get full text

Naloxonazine actions in vivo by Ling, G S, Simantov, R, Clark, J A, Pasternak, G W

“…Naloxonazine is a relatively selective mu 1 affinity label in binding studies. Like naloxazone, naloxonazine has proven valuable in vivo in establishing a role…”
Get more information

Distinct, developmentally regulated brain mRNAs direct the synthesis of neurotransmitter transporters by Blakely, R D, Clark, J A, Pacholczyk, T, Amara, S G

“…The Xenopus laevis oocyte expression system was utilized to define developmental and structural properties of neurotransmitter transporter mRNAs and the…”
Get more information