Search Results - "Clark, J. P."

Recurrence of Hepatocellular Carcinoma: Importance of mRECIST Response to Chemoembolization and Tumor Size by Kim, D. J., Clark, P. J., Heimbach, J., Rosen, C., Sanchez, W., Watt, K., Charlton, M. R.

“…Determining risk for recurrence of hepatocellular carcinoma (HCC) following liver transplantation (LT) is an important clinical need. We assessed consecutive…”
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Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice by Clark, P.J, Brzezinska, W.J, Thomas, M.W, Ryzhenko, N.A, Toshkov, S.A, Rhodes, J.S

“…Abstract The mammalian hippocampus continues to generate new neurons throughout life. Experiences such as exercise, anti-depressants, and stress regulate…”
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Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats by Arnold, M.R., Greenwood, B.N., McArthur, J.A., Clark, P.J., Fleshner, M., Lowry, C.A.

“…•Forced exercise increased c-Fos expression in DRC, DRI, and DRV serotonergic neurons.•Forced exercise increased FosB/ΔFosB expression in DRD, DRI, and DRV…”
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Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons by Clark, P.J, Bhattacharya, T.K, Miller, D.S, Rhodes, J.S

“…Abstract The functional significance of newly formed granule neurons in the adult mammalian hippocampus remains a mystery. Recently, it was demonstrated that…”
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Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer by Merson, S, Yang, Z H, Brewer, D, Olmos, D, Eichholz, A, McCarthy, F, Fisher, G, Kovacs, G, Berney, D M, Foster, C S, Møller, H, Scardino, P, Cuzick, J, Cooper, C S, Clark, J P

“…Background: Androgen receptor ( AR )-gene amplification, found in 20–30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a…”
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Repeated fear-induced diurnal rhythm disruptions predict PTSD-like sensitized physiological acute stress responses in F344 rats by Thompson, R. S., Strong, P. V., Clark, P. J., Maslanik, T. M., Wright Jr, K. P., Greenwood, B. N., Fleshner, M.

“…Aim To identify objective factors that can predict future sensitized stress responses, thus allowing for effective intervention prior to developing…”
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Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity by Warren, D.E, Bickler, P.E, Clark, J.P, Gregersen, M, Brosnan, H, McKleroy, W, Gabatto, P

“…Abstract This study examines the causes of hypothermia and rewarming injury in CA1, CA3, and dentate neurons in rat hippocampal slice cultures. Neuronal death,…”
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Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus by Clark, 3rd, J P, Kofuji, P

“…The circadian pacemaker within the suprachiasmatic nucleus (SCN) confers daily rhythms to bodily functions. In nature, the circadian clock will adopt a 24-h…”
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Genetic Variation in IL28B: Impact on Drug Development for Chronic Hepatitis C Infection by Clark, P J, Thompson, A J V, McHutchison, J G

“…As more pharmacogenomic insights into diseases and their treatments and toxicities are published each year, the challenge arises to incorporate such insights…”
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Drivers of Global Clear Sky Surface Downwelling Longwave Irradiance Trends From 1984 to 2017 by Clark, J. P., Clothiaux, E. E., Feldstein, S. B., Lee, S.

“…Radiation changes at the Earth's surface alter climate, however, the causes of observed surface radiation changes are not precisely quantified globally. With…”
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HIV protein, transactivator of transcription, alters circadian rhythms through the light entrainment pathway by Clark, 3rd, J P, Sampair, Christopher S, Kofuji, Paulo, Nath, Avindra, Ding, Jian M

“…Patients infected with the human immunodeficiency virus (HIV), and other mammals infected with related lentiviruses, exhibit fatigue, altered sleep patterns,…”
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Physical Apertures as Constraints on Egg Size and Shape in the Common Musk Turtle, Sternotherus odoratus by Clark, P. J., Ewert, M. A., Nelson, C. E.

“…1. Egg size in turtles often increases with female size, contrary to expectations of optimality. Functional constraints on egg width imposed by the pelvic…”
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Rising hospital admissions for alcohol-related cirrhosis and the impact of sex and comorbidity – a data linkage study by Sarraf, B., Skoien, R., Hartel, G., O'Beirne, J., Clark, P.J., Collins, L., Leggett, B., Powell, E.E., Valery, P.C.

“…International studies have shown shifting demographic data and rising hospitalizations for alcohol-related cirrhosis (ARC), with a paucity of data from…”
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Hypoxic preconditioning and cell death from oxygen/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons by Bickler, P.E, Clark, J.P, Gabatto, P, Brosnan, H

“…Highlights • The unfolded protein response (UPR) exerts key modulatory control on neuron survival. • Little is known about which parts of the UPR are important…”
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Using a Freeman FT4 rheometer and Electrical Capacitance Tomography to assess powder blending by Forte, G., Clark, P.J., Yan, Z., Stitt, E.H., Marigo, M.

“…This study assesses the influence of mixing or segregation on flowability results from a Freeman FT4 powder rheometer as well as the use of Electrical…”
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Genetic influences on exercise‐induced adult hippocampal neurogenesis across 12 divergent mouse strains by Clark, P. J., Kohman, R. A., Miller, D. S., Bhattacharya, T. K., Brzezinska, W. J., Rhodes, J. S.

“…New neurons are continuously born in the hippocampus of several mammalian species throughout adulthood. Adult neurogenesis represents a natural model for…”
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Liver‐related mortality in countries of the developed world: an ecological study approach to explain the variability by Wulffen, M., Clark, P. J., Macdonald, G. A., Raj, A. S., Kendall, B. J., Powell, E. E., Jones, M. P., Holtmann, G.

“…Summary Background Liver‐related mortality varies across developed nations. Aim To assess the relative role of various risk factors in relation to…”
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Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy by Clark, P. J., Aghemo, A., Degasperi, E., Galmozzi, E., Urban, T. J., Vock, D. M., Patel, K., Thompson, A. J., Rumi, M. G., D'Ambrosio, R., Muir, A. J., Colombo, M.

“…Summary Anaemia frequently complicates peginterferon/ribavirin therapy for chronic hepatitis C infection. Better prediction of anaemia, ribavirin dose…”
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Rate of heart failure and 1-year survival for older people receiving low-dose β-blocker therapy after myocardial infarction by Rochon, Paula A, Tu, Jack V, Anderson, Geoffrey M, Gurwitz, Jerry H, Clark, Jocalyn P, Lau, Paula, Szalai, John Paul, Sykora, Kathy, Naylor, C David

“…Many older people do not receive β-blocker therapy after myocardial infarction or receive doses lower than those tested in trials, perhaps because physicians…”
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Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis by Jazwinski, A. B., Thompson, A. J., Clark, P. J., Naggie, S., Tillmann, H. L., Patel, K.

“…Cytokeratin‐18 (CK‐18) is a major intermediate filament protein in liver cells. The M30 fragment of CK‐18 has been identified as a useful marker of apoptosis…”
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