Search Results - "Clark, I. M."

analysis of Pseudomonas genomic diversity in take‐all infected wheat fields reveals the lasting impact of wheat cultivars on the soil microbiota by Mauchline, T. H, Chedom‐Fotso, D, Chandra, G, Samuels, T, Greenaway, N, Backhaus, A, McMillan, V, Canning, G, Powers, S. J, Hammond‐Kosack, K. E, Hirsch, P. R, Clark, I. M, Mehrabi, Z, Roworth, J, Burnell, J, Malone, J. G

“…Manipulation of the soil microbiota associated with crop plants has huge promise for the control of crop pathogens. However, to fully realize this potential we…”
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Detection and quantification of Plectosphaerella cucumerina, a potential biological control agent of potato cyst nematodes, by using conventional PCR, real-time PCR, selective media, and baiting by Atkins, S.D, Clark, I.M, Sosnowska, D, Hirsch, P.R, Kerry, B.R

“…Potato cyst nematodes (PCN) are serious pests in commercial potato production, causing yield losses valued at approximately $300 million in the European…”
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Differential Toll-like receptor-dependent collagenase expression in chondrocytes by Zhang, Q, Hui, W, Litherland, G J, Barter, M J, Davidson, R, Darrah, C, Donell, S T, Clark, I M, Cawston, T E, Robinson, J H, Rowan, A D, Young, D A

“…To characterise the catabolic response of osteoarthritic chondrocytes to Toll-like receptor (TLR) ligands. Induction of the collagenases, matrix…”
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Old meets new: most probable number validation of metagenomic and metatranscriptomic datasets in soil by Mauchline, T.H., Hayat, R., Clark, I.M., Hirsch, P.R.

“…Metagenomics and metatranscriptomics provide insights into biological processes in complex substrates such as soil, but linking the presence and expression of…”
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Dietary intervention for osteoarthritis: Clinical trials after the ‘Bone and Joint Decade’ by Davidson, R. K, Clark, I. M

“…Osteoarthritis (OA) is a major social and economic burden that continues to grow globally with no effective disease modifying therapies in the pipeline…”
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Hepatocyte growth factor scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases by HARVEY, P, CLARK, I. M, JAURAND, M-C, WARN, R. M, EDWARDS, D. R

“…Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional factor involved both in development and tissue repair, as well as pathological processes…”
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TimiRGeN: R/Bioconductor package for time series microRNA–mRNA integration and analysis by Patel, K, Chandrasegaran, S, Clark, I M, Proctor, C J, Young, D A, Shanley, D P

“…Abstract Motivation The analysis of longitudinal datasets and construction of gene regulatory networks (GRNs) provide a valuable means to disentangle the…”
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Use of real-time quantitative PCR to investigate root and gall colonisation by co-inoculated isolates of the nematophagous fungus Pochonia chlamydosporia by Atkins, S.D, Peteira, B, Clark, I.M, Kerry, B.R, Hirsch, P.R

“…The fungus Pochonia chlamydosporia is a potential biological control agent for plant parasitic nematodes, but to date, there has been little investigation of…”
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Development of a defined compost system for the study of plant-microbe interactions by Masters-Clark, E., Shone, E., Paradelo, M., Hirsch, P. R., Clark, I. M., Otten, W., Brennan, F., Mauchline, T. H.

“…Plant growth promoting rhizobacteria can improve plant health by providing enhanced nutrition, disease suppression and abiotic stress resistance, and have…”
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Detection of IBV QX in commercial broiler flocks in the UK by Irvine, R. M., Cox, W. J., Ceeraz, V., Reid, S. M., Ellis, R. J., Jones, R. M., Errington, J., Wood, A. M., McVicar, C., Clark, M. I.

“…[...]during June 2009, investigation of an episode of increased mortality and respiratory signs in a commercial housed broiler flock in the east of England…”
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Rapid and reliable DNA extraction and PCR fingerprinting methods to discriminate multiple biotypes of the nematophagous fungus Pochonia chlamydosporia isolated from plant rhizospheres by Manzanilla-López, R.H, Clark, I.M, Atkins, S.D, Hirsch, P.R, Kerry, B.R

“…To develop a simple, rapid, reliable protocol producing consistent polymerase chain reaction (PCR) fingerprints of Pochonia chlamydosporia var. chlamydosporia…”
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Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role by Snelling, S.J.B, Davidson, R.K, Swingler, T.E, Le, L.T.T, Barter, M.J, Culley, K.L, Price, A, Carr, A.J, Clark, I.M

“…Summary Objective Dickkopf-3 (Dkk3) is a non-canonical member of the Dkk family of Wnt antagonists and its upregulation has been reported in microarray…”
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Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA by Crowe, N, Swingler, T.E, Le, L.T.T, Barter, M.J, Wheeler, G, Pais, H, Donell, S.T, Young, D.A, Dalmay, T, Clark, I.M

“…Summary Objective To use deep sequencing to identify novel microRNAs (miRNAs) in human osteoarthritic cartilage which have a functional role in chondrocyte…”
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Current concepts in osteolysis by OLLIVERE, B, WIMHURST, J. A, CLARK, I. M, DONELL, S. T

“…The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active…”
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Fragments of human fibroblast collagenase. Purification and characterization by Clark, I M, Cawston, T E

“…On purification, human fibroblast collagenase breaks down into two major forms (Mr22,000 and Mr 27,000) and one minor form (Mr 25,000). The most likely…”
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Effect of microbial activity on penetrometer resistance and elastic modulus of soil at different temperatures by Gao, W., Muñoz‐Romero, V., Ren, T., Ashton, R. W., Morin, M., Clark, I. M., Powlson, D. S., Whalley, W. R.

“…Summary We explore the effect of microbial activity stimulated by root exudates on the penetrometer resistance of soil and its elastic modulus. This is…”
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Control of the tissue inhibitor of metalloproteinases‐1 promoter in culture‐activated rat hepatic stellate cells: Regulation by activator protein‐1 DNA binding proteins by Bahr, Matthias J., Vincent, Karen J., Arthur, Michael J. P., Fowler, Andrew V., Smart, David E., Wright, Matthew C., Clark, Ian M., Benyon, R. Christopher, Iredale, John P., Mann, Derek A.

“…In the injured liver hepatic stellate cells (HSCs) undergo a dramatic phenotypic transformation known as “activation” in which they become myofibroblast‐like…”
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Can sulforaphane prevent the onset or slow the progression of osteoarthritis? by Davidson, R. K., Jupp, O., Bao, Y., MacGregor, A. J., Donell, S. T., Cassidy, A., Clark, I. M.

“…Osteoarthritis (OA) is a degenerative joint disease characterised in part by destruction of articular cartilage. There are currently no disease‐modifying drugs…”
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Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller by Li, J, Brick, P, O'Hare, MC, Skarzynski, T, Lloyd, LF, Curry, VA, Clark, IM, Bigg, HF, Hazleman, BL, Cawston, TE, Blow, DM

“…Background: The collagenases are members of the family of zinc-dependent enzymes known as the matrix metalloproteinases (MMPs). They are the only proteinases…”
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The Human Tissue Inhibitor of Metalloproteinases (TIMP)-1 Gene Contains Repressive Elements within the Promoter and Intron 1 by Dean, Greg, Young, David A., Edwards, Dylan R., Clark, Ian M.

“…Expression of the TIMP-1 (tissue inhibitor of metalloproteinases-1) gene is tightly controlled during embryonic development and in the adult animal. Previous…”
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