Search Results - "Clark, Emily S."

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior by Hoshino, Daisuke, Kirkbride, Kellye C., Costello, Kaitlin, Clark, Emily S., Sinha, Seema, Grega-Larson, Nathan, Tyska, Matthew J., Weaver, Alissa M.

“…Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in…”
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Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia by CLARK, Emily S, WHIGHAM, Amy S, YARBROUGH, Wendell G, WEAVER, Alissa M

“…Invadopodia are branched actin-rich structures associated with extracellular matrix (ECM) degradation that collectively form the invasive machinery of…”
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Extracellular Matrix Rigidity Promotes Invadopodia Activity by Alexander, Nelson R., Branch, Kevin M., Parekh, Aron, Clark, Emily S., Iwueke, Izuchukwu C., Guelcher, Scott A., Weaver, Alissa M.

“…Invadopodia are actin-rich subcellular protrusions with associated proteases used by cancer cells to degrade extracellular matrix (ECM) [1]. Molecular…”
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A new role for cortactin in invadopodia: regulation of protease secretion by Clark, Emily S, Weaver, Alissa M

“…Invadopodia are actin-dependent organelles that function in the invasion and remodeling of the extracellular matrix (ECM) by tumor cells. Cortactin, a…”
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Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk by Wright, Jacqueline A, Bazile, Cassandra, Clark, Emily S, Carlesso, Gianluca, Boucher, Justin, Kleiman, Eden, Mahmoud, Tamer, Cheng, Lily I, López-Rodríguez, Darlah M, Satterthwaite, Anne B, Altman, Norman H, Greidinger, Eric L, Khan, Wasif N

“…While apoptosis plays a role in B-cell self-tolerance, its significance in preventing autoimmunity remains unclear. Here, we report that dysregulated B cell…”
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Cortactin Promotes Cell Motility by Enhancing Lamellipodial Persistence by Bryce, Nicole S., Clark, Emily S., Leysath, Ja’Mes L., Currie, Joshua D., Webb, Donna J., Weaver, Alissa M.

“…Background: Lamellipodial protrusion, which is the first step in cell movement, is driven by actin assembly and requires activity of the Arp2/3…”
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Parental influences on pathogen resistance in brown trout embryos and effects of outcrossing within a river network by Clark, Emily S, Stelkens, Rike B, Wedekind, Claus

“…Phenotypic plasticity can increase tolerance to heterogeneous environments but the elevations and slopes of reaction norms are often population specific…”
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Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen by Kleiman, Eden, Salyakina, Daria, De Heusch, Magali, Hoek, Kristen L, Llanes, Joan M, Castro, Iris, Wright, Jacqueline A, Clark, Emily S, Dykxhoorn, Derek M, Capobianco, Enrico, Takeda, Akiko, Renauld, Jean-Christophe, Khan, Wasif N

“…Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular…”
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Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology by Kirkbride, Kellye C., Hong, Nan Hyung, French, Christi L., Clark, Emily S., Jerome, W. Gray, Weaver, Alissa M.

“…Cortactin is a branched actin regulator and tumor‐overexpressed protein that promotes vesicular trafficking at a variety of cellular sites, including endosomes…”
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The host-encoded Heme Regulated Inhibitor (HRI) facilitates virulence-associated activities of bacterial pathogens by Shrestha, Niraj, Boucher, Justin, Bahnan, Wael, Clark, Emily S, Rosqvist, Roland, Fields, Kenneth A, Khan, Wasif N, Schesser, Kurt

“…Here we show that cells lacking the heme-regulated inhibitor (HRI) are highly resistant to infection by bacterial pathogens. By examining the infection process…”
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Vaccination against neoantigens induced in cross-priming cDC1 in vivo by Clark, Emily S., Benaduce, Ana Paula, Khan, Wasif N., Martinez, Olivier, Gilboa, Eli

“…The conventional type 1 dendritic cells (cDC1) play a pivotal role in protective immunity against pathogens and cancer. However, their low frequency in the…”
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Btk Supports Autoreactive B Cell Development and Protects against Apoptosis but Is Expendable for Antigen Presentation by Nyhoff, Lindsay E, Griffith, Amber S, Clark, Emily S, Thomas, James W, Khan, Wasif N, Kendall, Peggy L

“…Bruton's tyrosine kinase (Btk) propagates B cell signaling, and BTK inhibitors are in clinical trials for autoimmune disease. Although autoreactive B cells…”
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Pathogen-induced hatching and population-specific life-history response to waterborne cues in brown trout (Salmo trutta) by Pompini, Manuel, Clark, Emily S., Wedekind, Claus

“…Hatching is an important niche shift, and embryos in a wide range of taxa can either accelerate or delay this life-history switch in order to avoid…”
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Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages by Nyhoff, Lindsay E, Clark, Emily S, Barron, Bridgette L, Bonami, Rachel H, Khan, Wasif N, Kendall, Peggy L

“…Bruton's tyrosine kinase (Btk) is a crucial regulator of B cell signaling and is a therapeutic target for lymphoma and autoimmune disease. BTK-deficient…”
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BTK drives neutrophil activation for sterilizing antifungal immunity by Desai, Jigar V, Zarakas, Marissa A, Wishart, Andrew L, Roschewski, Mark, Aufiero, Mariano A, Donkó, Ágnes, Wigerblad, Gustaf, Shlezinger, Neta, Plate, Markus, James, Matthew R, Lim, Jean K, Uzel, Gulbu, Bergerson, Jenna Re, Fuss, Ivan, Cramer, Robert A, Franco, Luis M, Clark, Emily S, Khan, Wasif N, Yamanaka, Daisuke, Chamilos, Georgios, El-Benna, Jamel, Kaplan, Mariana J, Staudt, Louis M, Leto, Thomas L, Holland, Steven M, Wilson, Wyndham H, Hohl, Tobias M, Lionakis, Michail S

“…We describe a previously-unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication…”
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Maternal and paternal contributions to pathogen resistance dependent on development stage in a whitefish (Salmonidae) by Clark, Emily S, Pompini, Manuel, Marques da Cunha, Lucas, Wedekind, Claus, Hawley, Dana

“…It is often assumed that maternal and paternal contributions to offspring phenotype change over the lifetime of an individual. However, studies on parental…”
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DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers by Gupta, Sachin, Clark, Emily S, Termini, James M, Boucher, Justin, Kanagavelu, Saravana, LeBranche, Celia C, Abraham, Sakhi, Montefiori, David C, Khan, Wasif N, Stone, Geoffrey W

“…Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1 envelope (Env) are believed to be essential for protection against…”
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Genetic correlations and little genetic variance for reaction norms may limit potential for adaptation to pollution by ionic and nanoparticulate silver in a whitefish (Salmonidae) by Clark, Emily S., Pompini, Manuel, Uppal, Anshu, Wedekind, Claus

“…For natural populations to adapt to anthropogenic threats, heritable variation must persist in tolerance traits. Silver nanoparticles, the most widely used…”
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MHC class I expression dependent on bacterial infection and parental factors in whitefish embryos (Salmonidae) by Clark, Emily S, Wilkins, Laetitia G. E, Wedekind, Claus

“…Ecological conditions can influence not only the expression of a phenotype, but also the heritability of a trait. As such, heritable variation for a trait…”
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B-lymphocyte tolerance and effector function in immunity and autoimmunity by Khan, Wasif N., Wright, Jacqueline A., Kleiman, Eden, Boucher, Justin C., Castro, Iris, Clark, Emily S.

“…B-lymphocytes are integral to host defense against microbial pathogens and are associated with many autoimmune diseases. The B-cell receptor implements B-cell…”
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