Search Results - "Clark, Edward A"

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity by Clark, Edward A, Giltiay, Natalia V

“…CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named "CD22" in 1984 at the 2nd…”
Get full text

The role of CD40 and CD154/CD40L in dendritic cells by Ma, Daphne Y, Clark, Edward A

“…Abstract In this review, we focus on the function of CD40–CD40L (CD154) interactions in the regulation of dendritic cell (DC)–T cell and DC–B cell crosstalk…”
Get full text

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness by Suthar, Mehul S., Ramos, Hilario J., Brassil, Margaret M., Netland, Jason, Chappell, Craig P., Blahnik, Gabriele, McMillan, Aimee, Diamond, Michael S., Clark, Edward A., Bevan, Michael J., Gale, Michael

“…The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection, but their roles in adaptive immunity have not been clearly defined…”
Get full text

B cell activating factor (BAFF) from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection by Kuley, Runa, Draves, Kevin E, Fuller, Deborah H, Giltiay, Natalia V, Clark, Edward A, Giordano, Daniela

“…Mice lacking B cells are more susceptible to S . typhimurium infection. How B cells contribute to protective immunity against Salmonella and what signals drive…”
Get full text

The intracellular progesterone receptor regulates CD4+ T cells and T cell-dependent antibody responses by Hughes, Grant C., Clark, Edward A., Wong, Alan H.

“…The intracellular progesterone receptor links the reproductive and immune systems via regulation of CD4+ T cells. Pg has distinct immunomodulatory properties…”
Get full text

Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8α− dendritic cell subset by Kasahara, Shinji, Clark, Edward A.

“…Surface expression of DCAL2 and DCIR2 subdivides CD8α‐DCs into functionally distinct subsets, which respond differently to TLR agonists and promote distinct Th…”
Get full text

IPS-1 is essential for the control of West Nile virus infection and immunity by Suthar, Mehul S, Ma, Daphne Y, Thomas, Sunil, Lund, Jennifer M, Zhang, Nu, Daffis, Stephane, Rudensky, Alexander Y, Bevan, Michael J, Clark, Edward A, Kaja, Murali-Krishna, Diamond, Michael S, Gale, Jr, Michael

“…The innate immune response is essential for controlling West Nile virus (WNV) infection but how this response is propagated and regulates adaptive immunity in…”
Get full text

A Short History of the B-Cell-Associated Surface Molecule CD40 by Clark, Edward A

“…This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates "T cell help"…”
Get full text

Regulation of B-cell fate by antigen-receptor signals by Clark, Edward A, Niiro, Hiroaki

“…Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints…”
Get full text

B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease by Giordano, Daniela, Kuley, Runa, Draves, Kevin E, Elkon, Keith B, Giltiay, Natalia V, Clark, Edward A

“…B cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti-BAFF…”
Get full text

Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling by Giltiay, Natalia V, Shu, Geraldine L, Shock, Anthony, Clark, Edward A

“…Abnormal B-cell activation is implicated in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). The B-cell surface molecule…”
Get full text

CD22 is required for formation of memory B cell precursors within germinal centers by Chappell, Craig P, Draves, Kevin E, Clark, Edward A

“…CD22 is a BCR co-receptor that regulates B cell signaling, proliferation and survival and is required for T cell-independent Ab responses. To investigate the…”
Get full text

Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory by Chaplin, Jay W, Chappell, Craig P, Clark, Edward A

“…Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic…”
Get full text

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells by Giltiay, Natalia V, Chappell, Craig P, Sun, Xizhang, Kolhatkar, Nikita, Teal, Thomas H, Wiedeman, Alice E, Kim, Jinoh, Tanaka, Lena, Buechler, Matthew B, Hamerman, Jessica A, Imanishi-Kari, Thereza, Clark, Edward A, Elkon, Keith B

“…Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both in systemic lupus…”
Get full text

Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses by Roe, Kelsey, Giordano, Daniela, Young, Lucy B, Draves, Kevin E, Holder, Ursula, Suthar, Mehul S, Gale, Jr, Michael, Clark, Edward A

“…Mitochondrial antiviral signaling protein (MAVS) is a critical innate immune signaling protein that directs the actions of the RIG-I-like receptor (RLR)…”
Get full text

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus by Baskin, Carole R, Bielefeldt-Ohmann, Helle, Tumpey, Terrence M, Sabourin, Patrick J, Long, James P, García-Sastre, Adolfo, Tolnay, Airn-E, Albrecht, Randy, Pyles, John A, Olson, Pam H, Aicher, Lauri D, Rosenzweig, Elizabeth R, Murali-Krishna, Kaja, Clark, Edward A, Kotur, Mark S, Fornek, Jamie L, Proll, Sean, Palermo, Robert E, Sabourin, Carol L, Katze, Michael G

“…The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly…”
Get full text

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization by Giordano, Daniela, Draves, Kevin E, Young, Lucy B, Roe, Kelsey, Bryan, Marianne A, Dresch, Christiane, Richner, Justin M, Diamond, Michael S, Gale, Jr, Michael, Clark, Edward A

“…B cell activating factor receptor (BAFFR)-/- mice have a profound reduction in mature B cells, but unlike μMT mice, they have normal numbers of newly formed,…”
Get full text

The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling by Gordiienko, Inna, Shlapatska, Larysa, Kholodniuk, Valeriia, Sklyarenko, Lilia, Gluzman, Daniel F, Clark, Edward A, Sidorenko, Svetlana P

“…Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL) associates with mutational IGHV status and favourable prognosis…”
Get full text

Splenic macrophages are required for protective innate immunity against West Nile virus by Bryan, Marianne A, Giordano, Daniela, Draves, Kevin E, Green, Richard, Gale, Jr, Michael, Clark, Edward A

“…Although the spleen is a major site for West Nile virus (WNV) replication and spread, relatively little is known about which innate cells in the spleen…”
Get full text

STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses by Ulrich-Lewis, Justin Theophilus, Draves, Kevin E, Roe, Kelsey, O'Connor, Megan A, Clark, Edward A, Fuller, Deborah Heydenburg

“…DNA vaccines elicit antibody, T helper cell responses and CD8 T cell responses. Currently, little is known about the mechanism that DNA vaccines employ to…”
Get full text