Search Results - "Clark, Denise V"

Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5 by O'Neill, Ryan S, Clark, Denise V

“…The septin family of hetero-oligomeric complex-forming proteins can be divided into subgroups, and subgroup members are interchangeable at specific positions…”
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Evolution of Three Parent Genes and Their Retrogene Copies in Drosophila Species by O'Neill, Ryan S., Clark, Denise V.

“…Retrogenes form a class of gene duplicate lacking the regulatory sequences found outside of the mRNA-coding regions of the parent gene. It is not clear how a…”
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The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis by O'Neill, Ryan S, Clark, Denise V

“…Septins are cytoskeletal proteins that form hetero-oligomeric complexes and function in many biological processes, including cytokinesis. Drosophila…”
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Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster by Merzetti, Eric, Hackett, Joanne M., Clark, Denise V.

“…The first step of the purine de novo synthesis pathway is catalyzed by amidophosphoribosyltransferase (E.C.2.4.2.14) which is encoded by two Prat genes in D…”
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A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster by Holland, Catherine, Lipsett, David B, Clark, Denise V

“…The biosynthetic pathways and multiple functions of purine nucleotides are well known. However, the pathways that respond to alterations in purine nucleotide…”
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The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway by O'Donnell, A F, Tiong, S, Nash, D, Clark, D V

“…Steps 6 and 7 of de novo purine synthesis are performed by 5-aminoimidazole ribonucleotide carboxylase (AIRc) and…”
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Modifiers of Prat, a de novo purine synthesis gene, in Drosophila melanogaster by Hackett, Joanne M, Clark, Denise V

“…Drosophila melanogaster was used to identify genes with a potential role in genetic regulation of purine biosynthesis. In this study we examine two dominant…”
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Expression Pattern Diversity and Functional Conservation Between Retroposed PRAT Genes from Drosophila melanogaster and Drosophila virilis by Penney, Jay, Bossé, Jessica, Clark, Denise V

“…Gene duplication by retrotransposition duplicates only the coding and untranslated regions of a gene and, thus, biases retroduplicated genes toward having…”
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Drosophila melanogaster Prat, a purine de novo synthesis gene, has a pleiotropic maternal-effect phenotype by Malmanche, N, Clark, D.V

“…In Drosophila melanogaster, two genes, Prat and Prat2, encode the enzyme, amidophosphoribosyltransferase, that performs the first and limiting step in purine…”
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The Purine Synthesis Gene Prat2 Is Required for Drosophila Metamorphosis, as Revealed by Inverted-Repeat-Mediated RNA Interference by Ji, Yingbiao, Clark, Denise V

“…PRAT (phosphoribosylamidotransferase; E.C. 2.4.2.14) catalyzes the first reaction in de novo purine nucleotide biosynthesis. In Drosophila melanogaster, the…”
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Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles by Langille, Morgan G.I., Clark, Denise V.

“…Genes arising by retrotransposition are always different from their parent genes from the outset. In addition, the cDNA must insert into a region that allows…”
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Identification of Trans-dominant Modifiers of Prat Expression in Drosophila melanogaster by Malmanche, Nicolas, Clark, Denise V

“…The first committed step in the purine de novo synthesis pathway is performed by amidophosphoribosyltransferase (EC 2.4.2.14) or Prat. Drosophila melanogaster…”
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The PRAT purine synthesis gene duplication in Drosophila melanogaster and Drosophila virilis is associated with a retrotransposition event and diversification of expression patterns by Malmanche, Nicolas, Drapeau, Dennis, Cafferty, Patrick, Ji, Yingbiao, Clark, Denise V

“…The Drosophila melanogaster Prat gene encodes amidophosphoribosyltransferase (PRAT; EC 2.4.2.14), which performs the first step in de novo purine nucleotide…”
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Repetitive arrays containing a housekeeping gene have altered polytene chromosome morphology in Drosophila by Clark, D.V, Sabl, J.F, Henikoff, S

“…Much of our understanding of gene and chromatin organization has been developed from observation of polytene chromosomes. We describe an experimental approach…”
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Genetic analysis and complementation by germ-line transformation of lethal mutations in the unc-22 IV region of Caenorhabditis elegans by Clark, D V, Baillie, D L

“…The subject of this study is the organization of essential genes in the 2 map-unit unc-22 IV region of the Caenorhabditis elegans genome. With the goal of…”
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Analysis of lethal mutations induced in a mutator strain that activates transposable elements in Caenorhabditis elegans by Clark, D V, Johnsen, R C, McKim, K S, Baillie, D L

“…A screen was conducted for lethal mutations in the nematode Caenorhabditis elegans in a strain containing the mutator mut-4 (st700)I to examine the nature of…”
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The purine biosynthesis enzyme PRAT detected in proenzyme and mature forms during development of Drosophila melanogaster by Clark, Denise V., MacAfee, Nancy

“…Glutamine phosphoribosylpyrophosphate amidotransferase (PRAT; EC 2.4.2.14) is the first and rate-limiting enzyme of de novo purine biosynthesis. PRAT…”
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Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis by Clark, D.V

“…The Drosophila Prat gene encodes phosphoribosylamidotransferase (PRAT), the enzyme that performs the first committed step of the de novo purine nucleotide…”
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Introduction of a DNA methyltransferase into Drosophila to probe chromatin structure in vivo by Wines, D R, Talbert, P B, Clark, D V, Henikoff, S

“…The dam DNA methyltransferase gene from Escherichia coli was introduced into Drosophila in order to probe chromatin structure in vivo. Expression of the gene…”
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Unusual organizational features of the Drosophila gart locus are not conserved within Diptera by Clark, D.V, Henikoff, S

“…The Drosophila Gart locus consists of two genes. One gene encodes three enzymes in the de novo purine nucleotide biosynthesis pathway [glycinamide…”
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