Search Results - "Clark, Darin P"

A neural network-based method for spectral distortion correction in photon counting x-ray CT by Touch, Mengheng, Clark, Darin P, Barber, William, Badea, Cristian T

“…Spectral CT using a photon counting x-ray detector (PCXD) shows great potential for measuring material composition based on energy dependent x-ray attenuation…”
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Hybrid spectral CT reconstruction by Clark, Darin P, Badea, Cristian T

“…Current photon counting x-ray detector (PCD) technology faces limitations associated with spectral fidelity and photon starvation. One strategy for addressing…”
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Spectral diffusion: an algorithm for robust material decomposition of spectral CT data by Clark, Darin P, Badea, Cristian T

“…Clinical successes with dual energy CT, aggressive development of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast…”
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Photon-counting cine-cardiac CT in the mouse by Clark, Darin P, Holbrook, Matthew, Lee, Chang-Lung, Badea, Cristian T

“…The maturation of photon-counting detector (PCD) technology promises to enhance routine CT imaging applications with high-fidelity spectral information. In…”
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Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study by Ashton, Jeffrey R, Clark, Darin P, Moding, Everett J, Ghaghada, Ketan, Kirsch, David G, West, Jennifer L, Badea, Cristian T

“…To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung…”
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High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry by Nadkarni, Rohan, Han, Zay Yar, Anderson, Robert J, Allphin, Alex J, Clark, Darin P, Badea, Alexandra, Badea, Cristian T

“…Brain region segmentation and morphometry in humanized apolipoprotein E (APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's disease…”
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Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients by Schwartz, Fides R., Clark, Darin P., Rigiroli, Francesca, Kalisz, Kevin, Wildman-Tobriner, Benjamin, Thomas, Sarah, Wilson, Joshua, Badea, Cristian T., Marin, Daniele

“…Objectives Evaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging. Methods Seventy-nine patients with…”
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Advanced photon counting CT imaging pipeline for cardiac phenotyping of apolipoprotein E mouse models by Allphin, Alex J, Mahzarnia, Ali, Clark, Darin P, Qi, Yi, Han, Zay Y, Bhandari, Prajwal, Ghaghada, Ketan B, Badea, Alexandra, Badea, Cristian T

“…Cardiovascular disease (CVD) is associated with the apolipoprotein E (APOE) gene and lipid metabolism. This study aimed to develop an imaging-based pipeline to…”
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Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography by Ding, Yifu, Vanselow, Daniel J, Yakovlev, Maksim A, Katz, Spencer R, Lin, Alex Y, Clark, Darin P, Vargas, Phillip, Xin, Xuying, Copper, Jean E, Canfield, Victor A, Ang, Khai C, Wang, Yuxin, Xiao, Xianghui, De Carlo, Francesco, van Rossum, Damian B, La Riviere, Patrick, Cheng, Keith C

“…Organismal phenotypes frequently involve multiple organ systems. Histology is a powerful way to detect cellular and tissue phenotypes, but is largely…”
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Dual-Energy Micro-Computed Tomography Imaging of Radiation-Induced Vascular Changes in Primary Mouse Sarcomas by Moding, Everett J., BA, Clark, Darin P., BS, Qi, Yi, MD, Li, Yifan, BS, Ma, Yan, BS, Ghaghada, Ketan, PhD, Johnson, G. Allan, PhD, Kirsch, David G., MD, PhD, Badea, Cristian T., PhD

“…Purpose To evaluate the effects of radiation therapy on primary tumor vasculature using dual-energy (DE) micro-computed tomography (micro-CT). Methods and…”
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A Deep Learning Approach for Rapid and Generalizable Denoising of Photon-Counting Micro-CT Images by Nadkarni, Rohan, Clark, Darin P, Allphin, Alex J, Badea, Cristian T

“…Photon-counting CT (PCCT) is powerful for spectral imaging and material decomposition but produces noisy weighted filtered backprojection (wFBP)…”
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Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning by Holbrook, Matthew D., Clark, Darin P., Patel, Rutulkumar, Qi, Yi, Bassil, Alex M., Mowery, Yvonne M., Badea, Cristian T.

“…We are developing imaging methods for a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform longitudinal micro-computed…”
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Photon Counting CT and Radiomic Analysis Enables Differentiation of Tumors Based on Lymphocyte Burden by Allphin, Alex J, Mowery, Yvonne M, Lafata, Kyle J, Clark, Darin P, Bassil, Alex M, Castillo, Rico, Odhiambo, Diana, Holbrook, Matthew D, Ghaghada, Ketan B, Badea, Cristian T

“…The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors…”
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MCR toolkit: A GPU‐based toolkit for multi‐channel reconstruction of preclinical and clinical x‐ray CT data by Clark, Darin P., Badea, Cristian T.

“…Background The advancement of x‐ray CT into the domains of photon counting spectral imaging and dynamic cardiac and perfusion imaging has created many new…”
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Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels by Nadkarni, Rohan, Allphin, Alex, Clark, Darin P, Badea, Cristian T

“…Photon-counting CT (PCCT) has better dose efficiency and spectral resolution than energy-integrating CT, which is advantageous for material decomposition…”
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In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT by Clark, Darin P, Ghaghada, Ketan, Moding, Everett J, Kirsch, David G, Badea, Cristian T

“…Tumor blood volume and vascular permeability are well established indicators of tumor angiogenesis and important predictors in cancer diagnosis, planning and…”
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Deep learning based spectral extrapolation for dual‐source, dual‐energy x‐ray computed tomography by Clark, Darin P., Schwartz, Fides R., Marin, Daniele, Ramirez‐Giraldo, Juan C., Badea, Cristian T.

“…Purpose Data completion is commonly employed in dual‐source, dual‐energy computed tomography (CT) when physical or hardware constraints limit the field of view…”
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Whole-animal imaging, gene function, and the Zebrafish Phenome Project by Cheng, Keith C, Xin, Xuying, Clark, Darin P, La Riviere, Patrick

“…Imaging can potentially make a major contribution to the Zebrafish Phenome Project, which will probe the functions of vertebrate genes through the generation…”
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Evaluating renal lesions using deep-learning based extension of dual-energy FoV in dual-source CT—A retrospective pilot study by Schwartz, Fides R., Clark, Darin P., Ding, Yuqin, Ramirez-Giraldo, Juan Carlos, Badea, Cristian T., Marin, Daniele

“…•Dual-energy information extrapolation for limited field of view is reliably achieved with custom deep-learning algorithm.•The algorithm performs with high…”
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Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish by Copper, Jean E., Budgeon, Lynn R., Foutz, Christina A., van Rossum, Damian B., Vanselow, Daniel J., Hubley, Margaret J., Clark, Darin P., Mandrell, David T., Cheng, Keith C.

“…In recognition of the importance of zebrafish as a model organism for studying human disease, we have created zebrafish content for a web-based reference atlas…”
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