Search Results - "Clark, Andrew J."

Copper Catalyzed Atom Transfer Radical Cyclization Reactions by Clark, Andrew J.

“…Atom transfer radical cyclization (ATRC) is a powerful technique to prepare functionalized 4–10 membered ring systems using transition metal catalysts. In this…”
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Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core by Clark, Andrew J., Davis, Mark E.

“…Most therapeutic agents are excluded from entering the central nervous system by the blood–brain barrier (BBB). Receptor mediated transcytosis (RMT) is a…”
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CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing by Clark, Andrew J., Wiley, Devin T., Zuckerman, Jonathan E., Webster, Paul, Chao, Joseph, Lin, James, Yen, Yun, Davis, Mark E.

“…Nanoparticle-based therapeutics are being used to treat patients with solid tumors. Whereas nanoparticles have been shown to preferentially accumulate in solid…”
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A Chemical Genomics Approach to Drug Reprofiling in Oncology: Antipsychotic Drug Risperidone as a Potential Adenocarcinoma Treatment by Dilly, Suzanne J, Clark, Andrew J, Marsh, Andrew, Mitchell, Daniel A, Cain, Ricky, Fishwick, Colin W.G, Taylor, Paul C

“…Abstract Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments. Herein, an antipsychotic drug is immobilised using the Magic…”
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Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine by Stork, Gilbert, Yamashita, Ayako, Hanson, Robert M, Phan, Ly, Phillips, Eifion, Dubé, Daniel, Bos, Pieter H, Clark, Andrew J, Gough, Maxwell, Greenlee, Mark L, Jiang, Yimin, Jones, Keith, Kitamura, Masato, Leonard, John, Liu, Tongzhu, Parsons, Philip J, Venkatesan, Aranapakam M

“…The total synthesis of 4-methylenegermine is described…”
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Mechanical properties of the cuticles of three cockroach species that differ in their wind-evoked escape behavior by Clark, Andrew J, Triblehorn, Jeffrey D

“…The structural and material properties of insect cuticle remain largely unexplored, even though they comprise the majority (approximately 80%) of animals…”
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Morphology and kinematics of feeding in hagfish: possible functional advantages of jaws by Clark, Andrew J, Summers, Adam P

“…As in gnathostomes, the hagfish feeding apparatus includes skeletal, dental and muscular components. In the present study, we examined feeding morphology and…”
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design of experiments (DoE) approach to material properties optimization of electrospun nanofibers by Coles, Stuart R, Jacobs, Daniel K, Meredith, James O, Barker, Guy, Clark, Andrew J, Kirwan, Kerry, Stanger, Jon, Tucker, Nick

“…Using an electrospinning technique, polymer materials have been spun using electrostatic potential to create a fiber mat. To develop the electrospinning…”
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Posture, speed, and habitat structure: three-dimensional hindlimb kinematics of two species of padless geckos by Fuller, Patrick O., Higham, Timothy E., Clark, Andrew J.

“…Differences in habitat use are often correlated with differences in morphology and behavior, while animals in similar habitats often exhibit similarities in…”
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A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins by Taylor, Paul C, Clark, Andrew J, Marsh, Andrew, Singer, Donald R J, Dilly, Suzanne J

“…Magic Tag® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe…”
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Solid-Supported Copper Catalysts for Atom-Transfer Radical Cyclizations:  Assessment of Support Type and Ligand Structure on Catalyst Performance in the Synthesis of Nitrogen Heterocycles by Clark, Andrew J, Geden, Joanna V, Thom, Stephen

“…A range of solid supported pyridinemethanimine 9−11 and polyamine 12−15 ligands have been prepared on silica, polystyrene, and JandaJel supports. The CuCl and…”
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Data preprocessing for anomaly based network intrusion detection: A review by Davis, Jonathan J., Clark, Andrew J.

“…Data preprocessing is widely recognized as an important stage in anomaly detection. This paper reviews the data preprocessing techniques used by anomaly-based…”
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Oxidative 5-Endo Cyclization of Enamides Mediated by Ceric Ammonium Nitrate by Clark, Andrew J, Dell, Colin P, McDonagh, John M, Geden, Joanna, Mawdsley, Peter

“…Ceric ammonium nitrate mediates the oxidative 5-endo radical−polar crossover reactions of β-enamide esters to give 5,5-C,O-disubstituted-γ-lactams. Trapping of…”
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Selective uptake of Ag(I) from aqueous solutions using ionic liquid-modified iron oxide nanoparticles by Aderibigbe, Abiodun D., Crane, Richard A., Lees, Martin R., Clark, Andrew J.

“…Surface functionalized magnetic nanoparticles represent a potentially highly valuable new suite of technologies for the selective recovery of metals from the…”
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N,S-donor acetamide ligand: silver (I) binding and test silver (I) extraction studies by Aderibigbe, Abiodun D., Clark, Andrew J.

“…Ligands bearing soft donors including N - and S - have found applications in selective metal recovery due to the ability to preferentially bind soft acceptors…”
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Individuals from non-native populations are stronger and bigger than individuals from native populations of a widespread seaweed by Murren, Courtney J., Krueger-Hadfield, Stacy A., Clark, Andrew J., Flanagan, Ben A., Lees, Lauren E., Sotka, Erik E.

“…Many species introduced to non-native regions undergo profound phenotypic change, but conflicting evidence remains on the frequency of such trait…”
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Novel N-(2-((4-vinylbenzyl)thio)ethyl)Acetamide Functionalized Magnetite Nanoparticle: Synthesis and Test Selective Silver(I) Removal Study by Aderibigbe, Abiodun D., Clark, Andrew J.

“…Magnetic nanoparticles embody a valuable suite of technologies for the selective recovery of metals from the aqueous phase owing to their high surface area,…”
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Synthesis, silver (I) extraction and silver (I) binding studies of novel N1,N3-bis(2-(benzylthio)ethyl)propanediamide derivatives by Aderibigbe, Abiodun D., Clark, Andrew J.

“…Solvent or liquid–liquid extraction represents a highly valuable technique for the selective recovery of metals from the aqueous phase due to the ease of…”
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Slipping, sliding and stability: locomotor strategies for overcoming low-friction surfaces by Clark, Andrew J, Higham, Timothy E

“…Legged terrestrial animals must avoid falling while negotiating unexpected perturbations inherent to their structurally complex environments. Among humans,…”
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Axially Chiral Enamides: Substituent Effects, Rotation Barriers, and Implications for their Cyclization Reactions by Clark, Andrew J, Curran, Dennis P, Fox, David J, Ghelfi, Franco, Guy, Collette S, Hay, Benjamin, James, Natalie, Phillips, Jessica M, Roncaglia, Fabrizio, Sellars, Philip B, Wilson, Paul, Zhang, Hanmo

“…The barrier to rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivatives was measured (ΔG ⧧ rotation varied between <8.0 and 31.0 kcal…”
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