Search Results - "Clark, Amanda"

Genitourinary syndrome of menopause—I know it when I see it—or do I? by Clark, Amanda L.

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Overactive bladder, stress urinary incontinence, and menopause—what are the associations? by Clark, Amanda L.

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Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α by Clark, Amanda J, Parikh, Samir M

“…The kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. Mitochondrial…”
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The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment by Ma, Bo, Wells, Alan, Clark, Amanda M.

“…Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that…”
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Modeling the Complexity of the Metastatic Niche Ex Vivo by Clark, Amanda M

“…Cancer mortality predominantly results from distant metastases that are undetectable at diagnosis and escape initial therapies to lie as dormant…”
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Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy by Khazali, Ahmad S, Clark, Amanda M, Wells, Alan

“…Background: Breast cancers can recur after a long latency period following ‘successful’ primary treatments. Chronic inflammation significantly correlates with…”
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Harmonizing outcomes for menopause research—a path forward by Clark, Amanda L.

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Mitochondrial Metabolism in Acute Kidney Injury by Clark, Amanda J., Parikh, Samir M.

“…The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for the active transport required to maintain water and solute…”
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Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer by Korentzelos, Dimitrios, Wells, Alan, Clark, Amanda M.

“…Interferon-γ (IFNγ) is a cytokine with limited evidence of benefit in cancer clinical trials to date. However, it could potentially play a role in potentiating…”
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Liver metastases: Microenvironments and ex-vivo models by Clark, Amanda M, Ma, Bo, Taylor, D Lansing, Griffith, Linda, Wells, Alan

“…The liver is a highly metastasis-permissive organ, tumor seeding of which usually portends mortality. Its unique and diverse architectural and cellular…”
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Mesenchymal Stem Cell-Secreted Exosomes and Soluble Signals Regulate Breast Cancer Metastatic Dormancy: Current Progress and Future Outlook by Dai, Bei, Clark, Amanda M, Wells, Alan

“…Breast cancer is most common in women, and in most cases there is no evidence of spread and the primary tumor is removed, resulting in a 'cure'. However, in…”
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The landscape of SETBP1 gene expression and transcription factor activity across human tissues by Whitlock, Jordan H, Wilk, Elizabeth J, Howton, Timothy C, Clark, Amanda D, Lasseigne, Brittany N

“…The SET binding protein 1 (SETBP1) gene encodes a transcription factor (TF) involved in various cellular processes. Variants in SETBP1 can result in three…”
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Statins attenuate outgrowth of breast cancer metastases by Beckwitt, Colin H., Clark, Amanda M., Ma, Bo, Whaley, Diana, Oltvai, Zoltán N., Wells, Alan

“…Background Metastasis in breast cancer foreshadows mortality, as clinically evident disease is aggressive and generally chemoresistant. Disseminated breast…”
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Treating where it hurts—a randomized comparative trial of vestibule estradiol for postmenopausal dyspareunia by Goetsch, Martha F., Garg, Bharti, Lillemon, Jen, Clark, Amanda L.

“…To compare efficacies of two strengths of estradiol cream applied to the vulvar vestibule and use of silicone lubricant to reduce intercourse pain scores in…”
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Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer by Marti, Juan Luis Gomez, Beckwitt, Colin H., Clark, Amanda M., Wells, Alan

“…Background Metastatic triple-negative breast cancer (mTNBC) is treated mainly with chemotherapy. However, resistance frequently occurs as tumours enter…”
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MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2 by Clark, Amanda L., Naya, Francisco J.

“…Understanding cell cycle regulation in postmitotic cardiomyocytes may lead to new therapeutic approaches to regenerate damaged cardiac tissue. We have…”
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Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells by Yang, Min, Ma, Bo, Shao, Hanshuang, Clark, Amanda M, Wells, Alan

“…Metastatic progression of breast cancer involves phenotypic plasticity of the carcinoma cells moving between epithelial and mesenchymal behaviors. During…”
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A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer by Korentzelos, Dimitrios, Clark, Amanda M, Wells, Alan

“…Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or…”
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Liver ‘organ on a chip’ by Beckwitt, Colin H., Clark, Amanda M., Wheeler, Sarah, Taylor, D. Lansing, Stolz, Donna B., Griffith, Linda, Wells, Alan

“…The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for…”
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Genitourinary Syndrome of Menopause: Pathophysiology, Clinical Presentation, and Differential Diagnosis by Clark, Amanda L, Goetsch, Martha F

“…Scientific information is incomplete regarding the genitourinary syndrome of menopause. Both the lower genital and urinary tracts are rich in receptors for…”
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