Search Results - "Clark, AK"

Microglial signalling mechanisms: Cathepsin S and Fractalkine by Clark, Anna K., Malcangio, Marzia

“…A recent major conceptual advance has been the recognition of the importance of immune system–neuron interactions in the modulation of spinal pain processing…”
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The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S by Clark, Anna K, Yip, Ping K, Malcangio, Marzia

“…Understanding of the sequence and nature of the events that govern neuron-microglia communication is critical for the discovery of new mechanisms and targets…”
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Neuropathic pain and cytokines: current perspectives by Clark, Anna K, Old, Elizabeth A, Malcangio, Marzia

“…Neuropathic pain represents a major problem in clinical medicine because it causes debilitating suffering and is largely resistant to currently available…”
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Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor by Clark, Anna K., Wodarski, Rachel, Guida, Francesca, Sasso, Oscar, Malcangio, Marzia

“…Microglia respond rapidly to injury, increasing their synthesis and release of inflammatory mediators, many of which contribute to the maintenance of…”
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Pathophysiology of Peripheral Neuropathic Pain: Immune Cells and Molecules by Thacker, Michael A., Clark, Anna K., Marchand, Fabien, McMahon, Stephen B.

“…Damage to the peripheral nervous system often leads to chronic neuropathic pain characterized by spontaneous pain and an exaggerated response to painful and/or…”
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Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model by Clark, Anna K., Grist, John, Al-Kashi, Adam, Perretti, Mauro, Malcangio, Marzia

“…Objective The induction of rheumatoid arthritis (RA) by active and passive immunization of mice results in the development of pain at the same time as the…”
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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain by Clark, Anna K, Yip, Ping K, Grist, John, Gentry, Clive, Staniland, Amelia A, Marchand, Fabien, Dehvari, Maliheh, Wotherspoon, Glen, Winter, Janet, Ullah, Jakir, Bevan, Stuart, Malcangio, Marzia

“…A recent major conceptual advance has been the recognition of the importance of immune system-neuronal interactions in the modulation of brain function, one…”
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Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice by Staniland, Amelia A, Clark, Anna K, Wodarski, Rachel, Sasso, Oscar, Maione, Francesco, D'Acquisto, Fulvio, Malcangio, Marzia

“…J. Neurochem. (2010) 114, 1143-1157. The chemokine fractalkine (FKN) is a critical mediator of spinal neuronal-microglial communication in chronic pain. Mature…”
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CCL2 is a key mediator of microglia activation in neuropathic pain states by Thacker, Michael A, Clark, Anna K, Bishop, Thomas, Grist, John, Yip, Ping K, Moon, Lawrence D.F, Thompson, Stephen W.N, Marchand, Fabien, McMahon, Stephen B

“…Abstract While neuroimmune interactions are increasingly recognized as important in nociceptive processing, the nature and functional significance of these…”
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Effects of Etanercept and Minocycline in a rat model of spinal cord injury by Marchand, Fabien, Tsantoulas, Christoforos, Singh, Dalbinder, Grist, John, Clark, Anna K, Bradbury, Elizabeth J, McMahon, Stephen B

“…Abstract Loss of function is usually considered the major consequence of spinal cord injury (SCI). However, pain severely compromises the quality of life in…”
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P57 Filling the gap for children with heart failure: the EU-funded drug development program LENA (labeling of enalapril from neonates up to adolescents) by Laeer, S, Breitkreutz, J, Klingmann, I, Lagler, F, Dalinghaus, M, Bajcetic, M, de Wildt, S, Clark, AK, Breur, H, Male, C, Jovanovic, I, Djukic, M, Mir, TS, Szatmári, A, Vukomanovi, V, Ablonczy, L, Burckhardt, BB, Cawello, W, Kleine, K, Obarcanin, E, Spatenkova, L, Swoboda, V, Van der Meulen, M, Wagner, P, Walsh, J

“…BackgroundACE-inhibitors are first choice treatment for adult and paediatric patients with heart failure. Since there are no systematic data on…”
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Role of the cysteine protease cathepsin S in neuropathic hyperalgesia by Barclay, Jane, Clark, Anna K., Ganju, Pam, Gentry, Clive, Patel, Sadhana, Wotherspoon, Glen, Buxton, Frank, Song, Chuanzheng, Ullah, Jakir, Winter, Janet, Fox, Alyson, Bevan, Stuart, Malcangio, Marzia

“…Using a gene expression analysis approach we found that the mRNA encoding the lysosomal cysteine protease cathepsin S (CatS) was up-regulated in rat dorsal…”
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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons by Minett, Michael S., Nassar, Mohammed A., Clark, Anna K., Passmore, Gayle, Dickenson, Anthony H., Wang, Fan, Malcangio, Marzia, Wood, John N.

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Fractalkine/CX3CR1 signalling in chronic pain and inflammation by Clark, Anna K, Staniland, Amelia A, Malcangio, Marzia

“…The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie chronic…”
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Progestins and acne vulgaris: a review by Bosanac, Suzana S, Trivedi, Megha, Clark, Ashley K, Sivamani, Raja K, Larsen, Larissa N

“…The role of exogenous progestin in the development of acne is unclear. Progestins are known for their androgenic potential, but newer generations of progestins…”
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Phytophotodermatitis related to carrot extract-containing sunscreen by Bosanac, S S, Clark, A K, Sivamani, R K

“…Phytophotodermatitis is a clinical diagnosis from phototoxicity of the skin induced by contact with plants or their extracts. Phytophotodermatitis maypresent…”
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Cloning and expression analysis of two novel paraflagellar rod domain genes found in Trypanosoma cruzi by CLARK, April K, KOVTUNOVYCH, Gennadiy, KANDLIKAR, Sachin, LAL, Shailesh, STRYKER, Gabrielle A

“…The eukaryotic flagellum is one of the most complex macromolecular structures found in cells, containing more than 250 proteins. One unique structure in the…”
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Racial Ideologies and the Quest for National Development: Debating the Agrarian Problem in Ecuador (1930–50) by CLARK, A. KIM

“…During an economic crisis in Ecuador, three models of and solutions to the agrarian problem were proposed. A peasant path of agricultural development was…”
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Race, 'Culture,' and Mestizaje: The Statistical Construction of the Ecuadorian Nation, 1930-1950 by Clark, A.

“…This article analyzes two statistical projects carried out in Ecuador: social reformer Dr. Pablo Arturo Suarez’ 1934 study of peasant and worker living…”
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Readability in technical writing-principles and procedures by Clark, Andrew K.

“…Technical writers apperently show little concern with the measurement of readability, defined as level of reading comprehension. Some evidense and reasons for…”
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