Search Results - "Claria, Joan"

Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome by Lopategi, Aritz, Flores‐Costa, Roger, Rius, Bibiana, López‐Vicario, Cristina, Alcaraz‐Quiles, José, Titos, Esther, Clària, Joan

“…The prototypic proinflammatory cytokine IL‐1β plays a central role in innate immunity and inflammatory disorders. The formation of mature IL‐1β from an…”
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Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides by López-Vicario, Cristina, Alcaraz-Quiles, José, García-Alonso, Verónica, Rius, Bibiana, Hwang, Sung H., Titos, Esther, Lopategi, Aritz, Hammock, Bruce D., Arroyo, Vicente, Clària, Joan

“…Significance Our study demonstrates that stabilization of cytochrome P-450 epoxides derived from omega-3 polyunsaturated fatty acids through inhibition of the…”
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Albumin in decompensated cirrhosis: new concepts and perspectives by Bernardi, Mauro, Angeli, Paolo, Claria, Joan, Moreau, Richard, Gines, Pere, Jalan, Rajiv, Caraceni, Paolo, Fernandez, Javier, Gerbes, Alexander L, O'Brien, Alastair J, Trebicka, Jonel, Thevenot, Thierry, Arroyo, Vicente

“…The pathophysiological background of decompensated cirrhosis is characterised by a systemic proinflammatory and pro-oxidant milieu that plays a major role in…”
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Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype by Titos, Esther, Rius, Bibiana, González-Périz, Ana, López-Vicario, Cristina, Morán-Salvador, Eva, Martínez-Clemente, Marcos, Arroyo, Vicente, Clària, Joan

“…We recently demonstrated that ω-3-polyunsaturated fatty acids ameliorate obesity-induced adipose tissue inflammation and insulin resistance. In this study, we…”
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Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis by Alcaraz‐Quiles, José, Casulleras, Mireia, Oettl, Karl, Titos, Esther, Flores‐Costa, Roger, Duran‐Güell, Marta, López‐Vicario, Cristina, Pavesi, Marco, Stauber, Rudolf E., Arroyo, Vicente, Clària, Joan

“…Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating…”
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Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure by Nielsen, Marlene Christina, Hvidbjerg Gantzel, Rasmus, Clària, Joan, Trebicka, Jonel, Møller, Holger Jon, Grønbæk, Henning

“…Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger…”
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Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis by García-Alonso, Verónica, Titos, Esther, Alcaraz-Quiles, Jose, Rius, Bibiana, Lopategi, Aritz, López-Vicario, Cristina, Jakobsson, Per-Johan, Delgado, Salvadora, Lozano, Juanjo, Clària, Joan

“…Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased…”
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Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins by González-Périz, Ana, Horrillo, Raquel, Ferré, Natàlia, Gronert, Karsten, Dong, Baiyan, Morán-Salvador, Eva, Titos, Esther, Martínez-Clemente, Marcos, López-Parra, Marta, Arroyo, Vicente, Clària, Joan

“…Omega-3-polyunsaturated fatty acids (ω-3-PUFAs) have well-documented protective effects that are attributed not only to eicosanoid inhibition but also to the…”
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Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue by Titos, Esther, Rius, Bibiana, López-Vicario, Cristina, Alcaraz-Quiles, José, García-Alonso, Verónica, Lopategi, Aritz, Dalli, Jesmond, Lozano, Juan José, Arroyo, Vicente, Delgado, Salvadora, Serhan, Charles N, Clària, Joan

“…Persistent activation of the innate immune system greatly influences the risk for developing metabolic complications associated with obesity. In this study, we…”
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Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation by Blaya, Delia, Coll, Mar, Rodrigo-Torres, Daniel, Vila-Casadesús, Maria, Altamirano, José, Llopis, Marta, Graupera, Isabel, Perea, Luis, Aguilar-Bravo, Beatriz, Díaz, Alba, Banales, Jesus M, Clària, Joan, Lozano, Juan José, Bataller, Ramon, Caballería, Juan, Ginès, Pere, Sancho-Bru, Pau

“…MicroRNAs (miRNAs) are well-known regulators of disease pathogenesis and have great potential as biomarkers and therapeutic targets. We aimed at profiling…”
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Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure by Zhang, Ingrid W., Curto, Anna, López-Vicario, Cristina, Casulleras, Mireia, Duran-Güell, Marta, Flores-Costa, Roger, Colsch, Benoit, Aguilar, Ferran, Aransay, Ana M., Lozano, Juan José, Hernández-Tejero, María, Toapanta, David, Fernández, Javier, Arroyo, Vicente, Clària, Joan

“…Patients with acute-on-chronic liver failure (ACLF) present a systemic hyperinflammatory response associated with increased circulating levels of…”
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Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis by Fernández, Javier, Clària, Joan, Amorós, Alex, Aguilar, Ferrán, Castro, Miriam, Casulleras, Mireia, Acevedo, Juan, Duran-Güell, Marta, Nuñez, Laura, Costa, Montserrat, Torres, Mireia, Horrillo, Raquel, Ruiz-del-Árbol, Luis, Villanueva, Cándido, Prado, Verónica, Arteaga, Mireya, Trebicka, Jonel, Angeli, Paolo, Merli, Manuela, Alessandria, Carlo, Aagaard, Niels Kristian, Soriano, German, Durand, François, Gerbes, Alexander, Gustot, Thierry, Welzel, Tania M., Salerno, Francesco, Bañares, Rafael, Vargas, Victor, Albillos, Agustin, Silva, Aníbal, Morales-Ruiz, Manuel, Carlos García-Pagán, Juan, Pavesi, Marco, Jalan, Rajiv, Bernardi, Mauro, Moreau, Richard, Páez, Antonio, Arroyo, Vicente

“…We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic…”
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Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease by López-Vicario, Cristina, Sebastián, David, Casulleras, Mireia, Duran-Güell, Marta, Flores-Costa, Roger, Aguilar, Ferran, Lozano, Juan José, Zhang, Ingrid W, Titos, Esther, Kang, Jing X, Zorzano, Antonio, Arita, Makoto, Clària, Joan

“…Injury to hepatocyte mitochondria is common in metabolic dysfunction-associated fatty liver disease. Here, we investigated whether changes in the content of…”
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HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure by Trieb, Markus, Rainer, Florian, Stadlbauer, Vanessa, Douschan, Philipp, Horvath, Angela, Binder, Lukas, Trakaki, Athina, Knuplez, Eva, Scharnagl, Hubert, Stojakovic, Tatjana, Heinemann, Ákos, Mandorfer, Mattias, Paternostro, Rafael, Reiberger, Thomas, Pitarch, Carla, Amorós, Alex, Gerbes, Alexander, Caraceni, Paolo, Alessandria, Carlo, Moreau, Richard, Clària, Joan, Marsche, Gunther, Stauber, Rudolf E.

“…High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During…”
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Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF by Zaccherini, Giacomo, Aguilar, Ferran, Caraceni, Paolo, Clària, Joan, Lozano, Juan José, Fenaille, François, Castelli, Florence, Junot, Christophe, Curto, Anna, Formentin, Chiara, Weiss, Emmanuel, Bernardi, Mauro, Jalan, Rajiv, Angeli, Paolo, Moreau, Richard, Arroyo, Vicente

“…Systemic inflammation and organ failure(s) are the hallmarks of acute-on-chronic liver failure (ACLF), yet their pathogenesis remains uncertain. Herein, we…”
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Diversity of lipid mediators in human adipose tissue depots by Clària, Joan, Nguyen, Binh T, Madenci, Arin L, Ozaki, C Keith, Serhan, Charles N

“…Adipose tissue is a heterogeneous organ with remarkable variations in fat cell metabolism depending on the anatomical location. However, the pattern and…”
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The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia‐induced endoplasmic reticulum stress by Rius, Bibiana, Duran‐Güell, Marta, Flores‐Costa, Roger, López‐Vicario, Cristina, Lopategi, Aritz, Alcaraz‐Quiles, José, Casulleras, Mireia, José Lozano, Juan, Titos, Esther, Clària, Joan

“…ABSTRACT Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) are hallmarks of nonalcoholic fatty liver disease (NAFLD),…”
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Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis by López-Vicario, Cristina, González-Périz, Ana, Rius, Bibiana, Morán-Salvador, Eva, García-Alonso, Verónica, Lozano, Juan José, Bataller, Ramón, Cofán, Montserrat, Kang, Jing X, Arroyo, Vicente, Clària, Joan, Titos, Esther

“…The mechanisms underlying non-alcoholic steatohepatitis (NASH) are not completely elucidated. In the current study we integrated gene expression profiling of…”
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Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis by Clària, Joan, Curto, Anna, Moreau, Richard, Colsch, Benoit, López-Vicario, Cristina, Lozano, Juan José, Aguilar, Ferran, Castelli, Florence A., Fenaille, François, Junot, Christophe, Zhang, Ingrid, Vinaixa, Maria, Yanes, Oscar, Caraceni, Paolo, Trebicka, Jonel, Fernández, Javier, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente

“…Acute decompensation (AD) of cirrhosis is a heterogeneous clinical entity associated with moderate mortality. In some patients, this condition develops quickly…”
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Role for PPARγ in obesity‐induced hepatic steatosis as determined by hepatocyte‐ and macrophage‐specific conditional knockouts by Morán‐Salvador, Eva, López‐Parra, Marta, García‐Alonso, Verónica, Titos, Esther, Martínez‐Clemente, Marcos, González‐Périz, Ana, López‐Vicario, Cristina, Barak, Yaacov, Arroyo, Vicente, Clària, Joan

“…ABSTRACT Peroxisome proliferator‐activated receptor (PPAR) γ is a nuclear receptor central to glucose and lipid homeostasis. PPARγ role in nonalcoholic fatty…”
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