Search Results - "Clare Griffin"

Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial by Dearnaley, David, Prof, Syndikus, Isabel, MD, Mossop, Helen, MMathStat, Khoo, Vincent, MD, Birtle, Alison, FRCR, Bloomfield, David, FRCR, Graham, John, FRCR, Kirkbride, Peter, FRCR, Logue, John, FRCR, Malik, Zafar, FRCR, Money-Kyrle, Julian, FRCR, O'Sullivan, Joe M, Prof, Panades, Miguel, MRCR, Parker, Chris, FRCR, Patterson, Helen, FRCR, Scrase, Christopher, FRCR, Staffurth, John, MD, Stockdale, Andrew, FRCR, Tremlett, Jean, MSc, Bidmead, Margaret, MSc, Mayles, Helen, MSc, Naismith, Olivia, MSc, South, Chris, PhD, Gao, Annie, MSc, Cruickshank, Clare, BSc[Hons], Hassan, Shama, MSc, Pugh, Julia, CIM Dip, Griffin, Clare, MSc, Hall, Emma, PhD

“…Summary Background Prostate cancer might have high radiation-fraction sensitivity that would give a therapeutic advantage to hypofractionated treatment. We…”
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International Society of Urological Pathology (ISUP) Gleason Grade Groups stratify outcomes in the CHHiP Phase 3 prostate radiotherapy trial by Dearnaley, David, Griffin, Clare L., Silva, Pedro, Wilkins, Anna, Stuttle, Christine, Syndikus, Isabel, Hassan, Shama, Pugh, Julia, Cruickshank, Clare, Hall, Emma, Corbishley, Catherine M.

“…Objectives To compare the results of Gleason Grade Group (GGG) classification following central pathology review with previous local pathology assessment, and…”
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Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial by Coles, Charlotte E, Griffin, Clare L, Kirby, Anna M, Titley, Jenny, Agrawal, Rajiv K, Alhasso, Abdulla, Bhattacharya, Indrani S, Brunt, Adrian M, Ciurlionis, Laura, Chan, Charlie, Donovan, Ellen M, Emson, Marie A, Harnett, Adrian N, Haviland, Joanne S, Hopwood, Penelope, Jefford, Monica L, Kaggwa, Ronald, Sawyer, Elinor J, Syndikus, Isabel, Tsang, Yat M, Wheatley, Duncan A, Wilcox, Maggie, Yarnold, John R, Bliss, Judith M, Al Sarakbi, Wail, Barber, Sarah, Barnett, Gillian, Bliss, Peter, Dewar, John, Eaton, David, Ebbs, Stephen, Ellis, Ian, Evans, Philip, Harris, Emma, James, Hayley, Kirwan, Cliona, Kirk, Julie, Mayles, Helen, McIntyre, Anne, Mills, Judith, Poynter, Andrew, Provenzano, Elena, Rawlings, Christine, Sculpher, Mark, Sumo, Georges, Sydenham, Mark, Tutt, Andrew, Twyman, Nicola, Venables, Karen, Winship, Anna, Winstanley, John, Wishart, Gordon, Thompson, Alastair

“…Local cancer relapse risk after breast conservation surgery followed by radiotherapy has fallen sharply in many countries, and is influenced by patient age and…”
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Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial by Rustin, Gordon JS, Prof, van der Burg, Maria EL, MD, Griffin, Clare L, MSc, Guthrie, David, FRCR, Lamont, Alan, FRCR, Jayson, Gordon C, Prof, Kristensen, Gunnar, MD, Mediola, César, MD, Coens, Corneel, MSc, Qian, Wendi, PhD, Parmar, Mahesh KB, Prof, Swart, Ann Marie, Dr

“…Summary Background Serum CA125 concentration often rises several months before clinical or symptomatic relapse in women with ovarian cancer. In the MRC…”
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Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial by Brunt, A. Murray, Wheatley, Duncan, Yarnold, John, Somaiah, Navita, Kelly, Stephen, Harnett, Adrian, Coles, Charlotte, Goodman, Andrew, Bahl, Amit, Churn, Mark, Zotova, Rada, Sydenham, Mark, Griffin, Clare L, Morden, James P, Bliss, Judith M

“…Abstract Background and purpose FAST-Forward is a phase 3 clinical trial testing a 1-week course of whole breast radiotherapy against the UK standard 3-week…”
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Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL) by Dearnaley, David, Griffin, Clare L., Lewis, Rebecca, Mayles, Philip, Mayles, Helen, Naismith, Olivia F., Harris, Victoria, Scrase, Christopher D., Staffurth, John, Syndikus, Isabel, Zarkar, Anjali, Ford, Daniel R., Rimmer, Yvonne L., Horan, Gail, Khoo, Vincent, Frew, John, Venkitaraman, Ramachandran, Hall, Emma

“…To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at…”
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Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial by Coles, Charlotte E, Haviland, Joanne S, Kirby, Anna M, Griffin, Clare L, Sydenham, Mark A, Titley, Jenny C, Bhattacharya, Indrani, Brunt, A Murray, Chan, H Y Charlie, Donovan, Ellen M, Eaton, David J, Emson, Marie, Hopwood, Penny, Jefford, Monica L, Lightowlers, Sara V, Sawyer, Elinor J, Syndikus, Isabel, Tsang, Yat M, Twyman, Nicola I, Yarnold, John R, Bliss, Judith M

“…A tumour-bed boost delivered after whole-breast radiotherapy increases local cancer-control rates but requires more patient visits and can increase breast…”
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Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial by Wilkins, Anna, FRCR, Mossop, Helen, MMathStat, Syndikus, Isabel, FRCR, Khoo, Vincent, MD, Bloomfield, David, FRCR, Parker, Chris, FRCR, Logue, John, FRCR, Scrase, Christopher, FRCR, Patterson, Helen, FRCR, Birtle, Alison, FRCR, Staffurth, John, MD, Malik, Zafar, FRCR, Panades, Miguel, MRCR, Eswar, Chinnamani, FRCR, Graham, John, FRCR, Russell, Martin, FRCR, Kirkbride, Peter, FRCR, O'Sullivan, Joe M, Prof, Gao, Annie, MSc, Cruickshank, Clare, BSc (Hons), Griffin, Clare, MSc, Dearnaley, David, Prof, Hall, Emma, Dr

“…Summary Background Patient-reported outcomes (PROs) might detect more toxic effects of radiotherapy than do clinician-reported outcomes. We did a quality of…”
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A randomized control trial evaluating fluorescent ink versus dark ink tattoos for breast radiotherapy by Landeg, Steven J, Kirby, Anna M, Lee, Steven F, Bartlett, Freddie, Titmarsh, Kumud, Donovan, Ellen, Griffin, Clare L, Gothard, Lone, Locke, Imogen, McNair, Helen A

“…The purpose of this UK study was to evaluate interfraction reproducibility and body image score when using ultraviolet (UV) tattoos (not visible in ambient…”
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Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial by Gore, Martin E, Prof, Griffin, Clare L, MSc, Hancock, Barry, Prof, Patel, Poulam M, Prof, Pyle, Lynda, BSc, Aitchison, Michael, MD, James, Nicholas, Prof, Oliver, Roderick TD, Prof, Mardiak, Jozef, MD, Hussain, Tahera, DPhil, Sylvester, Richard, ScD, Parmar, Mahesh KB, Prof, Royston, Patrick, Prof, Mulders, Peter FA, Prof

“…Summary Background In metastatic renal cell carcinoma combinations of interferon alfa-2a, interleukin-2, and fluorouracil produce higher response rates and…”
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Dose-escalated intensity-modulated radiotherapy in patients with locally advanced laryngeal and hypopharyngeal cancers: ART DECO, a phase III randomised controlled trial by Nutting, Christopher M., Griffin, Clare L., Sanghera, Paul, Foran, Bernadette, Beasley, Matthew, Bernstein, David, Cosgrove, Vivian, Fisher, Shelia, West, Catherine M., Sibtain, Amen, Palaniappan, Nachi, Urbano, Teresa Guerrero, Sen, Mehmet, Soe, Win, Rizwanullah, Mohammed, Wood, Katie, Ramkumar, Shanmugasundaram, Junor, Elizabeth, Cook, Audrey, Roques, Tom, Scrase, Christopher, Bhide, Shreerang A., Gujral, Dorothy, Harrington, Kevin J., Mehanna, Hisham, Miah, Aisha, Emson, Marie, Gardiner, Deborah, Morden, James P., Hall, Emma

“…Radical (chemo)radiotherapy offers potentially curative treatment for patients with locally advanced laryngeal or hypopharyngeal cancer. We aimed to show that…”
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Protocol for tumour-focused dose-escalated adaptive radiotherapy for the radical treatment of bladder cancer in a multicentre phase II randomised controlled trial (RAIDER): radiotherapy planning and delivery guidance by Hafeez, Shaista, Webster, Amanda, Hansen, Vibeke N, McNair, Helen A, Warren-Oseni, Karole, Patel, Emma, Choudhury, Ananya, Creswell, Joanne, Foroudi, Farshad, Henry, Ann, Kron, Tomas, McLaren, Duncan B, Mitra, Anita V, Mostafid, Hugh, Saunders, Daniel, Miles, Elizabeth, Griffin, Clare, Lewis, Rebecca, Hall, Emma, Huddart, Robert

“…IntroductionDaily radiotherapy delivered with radiosensitisation offers patients with muscle invasive bladder cancer (MIBC) comparable outcomes to cystectomy…”
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Letter in response to the Wedlake et al. paper ‘Evaluating the efficacy of statins and ACE-inhibitors in reducing gastrointestinal toxicity in patients receiving radiotherapy for pelvic malignancies’ by Dearnaley, David, Griffin, Clare L, Hall, Emma

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Linkage of the CHHiP randomised controlled trial with primary care data: a study investigating ways of supplementing cancer trials and improving evidence-based practice by Lemanska, Agnieszka, Byford, Rachel C, Cruickshank, Clare, Dearnaley, David P, Ferreira, Filipa, Griffin, Clare, Hall, Emma, Hinton, William, de Lusignan, Simon, Sherlock, Julian, Faithfull, Sara

“…Randomised controlled trials (RCTs) are the gold standard for evidence-based practice. However, RCTs can have limitations. For example, translation of findings…”
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PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018) by Syndikus, Isabel, Cruickshank, Clare, Staffurth, John, Tree, Alison, Henry, Ann, Naismith, Olivia, Mayles, Helen, Snelson, Nicola, Hassan, Shama, Brown, Stephanie, Porta, Nuria, Griffin, Clare, Hall, Emma

“…•PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are…”
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TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer by Thomson, David J., Cruickshank, Clare, Baines, Helen, Banner, Russell, Beasley, Matthew, Betts, Guy, Bulbeck, Helen, Charlwood, Frances, Christian, Judith, Clarke, Matthew, Donnelly, Olly, Foran, Bernadette, Gillies, Callum, Griffin, Clare, Homer, Jarrod J., Langendijk, Johannes A., Lee, Lip Wai, Lester, James, Lowe, Matthew, McPartlin, Andrew, Miles, Elizabeth, Nutting, Christopher, Palaniappan, Nachi, Prestwich, Robin, Price, James M., Roberts, Clare, Roe, Justin, Shanmugasundaram, Ramkumar, Simões, Rita, Thompson, Anna, West, Catharine, Wilson, Lorna, Wolstenholme, Jane, Hall, Emma

“…•There is a lack of prospective level I evidence for the use of PBT for most adult cancers including oropharyngeal squamous cell carcinoma (OPSCC).•TORPEdO is…”
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Introduction: The Natural Turn in Early Modern Russian History by Graber, Anna, Griffin, Clare, Koroloff, Rachel, Yoder, Audra

“…This introduction to the Vivliofika special issue, Animal, Vegetable, Mineral, illuminates the rich scholarship examining ideas about nature in the early…”
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How informed is declared altruism in clinical trials? A qualitative interview study of patient decision-making about the QUEST trials (Quality of Life after Mastectomy and Breast Reconstruction) by Bidad, Natalie, MacDonald, Lindsay, Winters, Zoë E, Edwards, Sarah J L, Emson, Marie, Griffin, Clare L, Bliss, Judith, Horne, Rob

“…Randomised controlled trials (RCTs) often fail to recruit sufficient participants, despite altruism being cited as their motivation. Previous investigations of…”
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Evaluation of erectile potency and radiation dose to the penile bulb using image guided radiotherapy in the CHHiP trial by Murray, Julia, Gulliford, Sarah, Griffin, Clare, Wilkins, Anna, Syndikus, Isabel, Staffurth, John, Panades, Miguel, Scrase, Christopher, Parker, Chris, Khoo, Vincent, Dean, Jamie, Mayles, Helen, Mayles, Philip, Thomas, Simon, Naismith, Olivia, Mossop, Helen, Cruickshank, Clare, Hall, Emma, Dearnaley, David

“…•Dosimetric benefits to the penile bulb was seen in patients treated with IGRT and reduced CTV-PTV margins.•Patients who had a lower planned dose to the penile…”
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PEARLS – A multicentre phase II/III trial of extended field radiotherapy for androgen sensitive prostate cancer patients with PSMA‐avid pelvic and/or para-aortic lymph nodes at presentation by Murray, Julia, Cruickshank, Clare, Bird, Thomas, Bell, Philip, Braun, John, Chuter, Dave, Ferreira, Miguel Reis, Griffin, Clare, Hassan, Shama, Hujairi, Nabil, Melcher, Alan, Miles, Elizabeth, Naismith, Olivia, Panades, Miguel, Philipps, Lara, Reid, Alison, Rekowski, Jan, Sankey, Pete, Staffurth, John, Syndikus, Isabel, Tree, Alison, Wilkins, Anna, Hall, Emma

“…•PEARLS investigates a patient group, for which there have been no prospective randomised trials evaluating the effect of radiotherapy.•PSMA-PET imaging is…”
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