Search Results - "Clare, Rumi"

T cell–mediated autoimmunity in immune thrombocytopenia by Vrbensky, John R., Nazy, Ishac, Clare, Rumi, Larché, Mark, Arnold, Donald M.

“…Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti‐platelet…”
Get full text

Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia by Huynh, Angela, Arnold, Donald M., Kelton, John G., Smith, James W., Horsewood, Peter, Clare, Rumi, Guarné, Alba, Nazy, Ishac

“…Essentials Many patients produce antibodies but few lead to heparin‐induced thrombocytopenia (HIT). Pathogenic epitopes are difficult to identify as HIT…”
Get full text

Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia by Nazy, Ishac, Kelton, John G., Moore, Jane C., Clare, Rumi, Horsewood, Peter, Smith, James W., Ivetic, Nikola, D'Souza, Vanessa, Li, Na, Arnold, Donald M.

“…Summary Autoantibodies to thrombopoietin (TPO, also termed THPO) or the TPO receptor (cMpl, also termed MPL) could play a pathological role in immune…”
Get full text

Increased cytotoxic potential of CD8+ T cells in immune thrombocytopenia by Vrbensky, John R., Arnold, Donald M., Kelton, John G., Smith, James W., Jaffer, Anushka M., Larché, Mark, Clare, Rumi, Ivetic, Nikola, Nazy, Ishac

Get full text

Misdiagnosis of primary immune thrombocytopenia and frequency of bleeding: lessons from the McMaster ITP Registry by Arnold, Donald M., Nazy, Ishac, Clare, Rumi, Jaffer, Anushka M., Aubie, Brandon, Li, Na, Kelton, John G.

“…Nonspecific diagnostic criteria and uncertain estimates of severe bleeding events are fundamental gaps in knowledge of primary immune thrombocytopenia (ITP)…”
Get full text

Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study by Leong, Darryl P, Zhang, Ali, Breznik, Jessica A, Clare, Rumi, Huynh, Angela, Mushtaha, Maha, Rangarajan, Sumathy, Stacey, Hannah, Kim, Paul Y, Loeb, Mark, Denburg, Judah A, Mertz, Dominik, Chagla, Zain, Nazy, Ishac, Miller, Matthew S, Bowdish, Dawn M E, Duong, MyLinh

“…The dosing interval of a primary vaccination series can significantly impact on vaccine immunogenicity and efficacy. The current study compared 3 dosing…”
Get full text

Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects by Huynh, Angela, Arnold, Donald M, Smith, James W, Moore, Jane C, Zhang, Ali, Chagla, Zain, Harvey, Bart J, Stacey, Hannah D, Ang, Jann C, Clare, Rumi, Ivetic, Nikola, Chetty, Vasudhevan T, Bowdish, Dawn M E, Miller, Matthew S, Kelton, John G, Nazy, Ishac

“…Coronavirus Disease 2019 (COVID-19) is a global pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While detection of…”
Get full text

Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4 by Yang, Yang, Du, Yi, Ivanov, Daniil, Niu, Chendi, Clare, Rumi, Smith, James W., Nazy, Ishac, Kaltashov, Igor A.

“…Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis…”
Get full text

Producing megakaryocytes from a human peripheral blood source by Ivetic, Nikola, Nazi, Ishac, Karim, Nadia, Clare, Rumi, Smith, James W., Moore, Jane C., Hope, Kristin J., Kelton, John G., Arnold, Donald M.

“…BACKGROUND Cultured megakaryocytes could prove useful in the study of human diseases, but it is difficult to produce sufficient numbers for study. We describe…”
Get full text

Longitudinal Characteristics of Anti-Platelet Factor 4 Immunoglobulin G in Vaccine-Induced Immune Thrombotic Thrombocytopenia by Huynh, Angela, Arnold, Donald M., Smith, James W., Clare, Rumi, Ivetic, Nikola, Moore, Jane C., Kelton, John G., Nazy, Ishac

Get full text

Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia by Huynh, Angela, Arnold, Donald M., Ivetic, Nikola, Clare, Rumi, Hadzi-Tosev, Milena, Liu, Yang, Smith, James W., Bissola, Anna-Lise, Daka, Mercy, Kelton, John G., Nazy, Ishac

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication of adenoviral vector–based vaccines against SARS-CoV-2. This syndrome is…”
Get full text

Pathogenic Antibodies in Heparin-Induced Thrombocytopenia Specifically Target an Immunodominant Region on Platelet Factor 4 by Huynh, Angela, Arnold, Donald M., Kelton, John G., Clare, Rumi, Ivanova, Marina, Nazy, Ishac

“…Introduction: Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction that occurs when heparin binds to platelet factor 4 (PF4) forming immunogenic…”
Get full text

Evaluation of laboratory testing parameters for vaccine-induced immune thrombotic thrombocytopenia and their implications for diagnosis by Bissola, Anna-Lise, Daka, Mercy, Ivetic, Nikola, Clare, Rumi, Pai, Menaka, Kelton, John G, Arnold, Donald M, Nazy, Ishac

Get full text

Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine by Leong, Darryl P, Zhang, Ali, Breznik, Jessica A, Clare, Rumi, Huynh, Angela, Mushtaha, Maha, Rangarajan, Sumathy, Stacey, Hannah, Kim, Paul Y, Loeb, Mark, Denburg, Judah A, Mertz, Dominik, Chagla, Zain, Nazy, Ishac, Miller, Matthew S, Bowdish, Dawn M. E, Duong, MyLinh

“…Objectives The dosing interval of a primary vaccination series can significantly impact on vaccine immunogenicity and efficacy. The current study compared 3…”
Get full text

The use of 1E12, a monoclonal anti-platelet factor 4 antibody, to improve the diagnosis of vaccine-induced immune thrombotic thrombocytopenia by Vayne, Caroline, Rollin, Jérôme, Clare, Rumi, Daka, Mercy, Atsouawe, Merveille, Guéry, Eve-Anne, Cauchie, Philippe, Cordonnier, Charlotte, Cuisenier, Pauline, De Maistre, Emmanuel, Donnard, Magali, Drillaud, Nicolas, Faille, Dorothée, Galinat, Hubert, Gouin-Thibault, Isabelle, Lemoine, Sandrine, Mourey, Guillaume, Mullier, François, Siguret, Virginie, Susen, Sophie, Godon, Alban, Nazy, Ishac, Gruel, Yves, Pouplard, Claire

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a complication of adenoviral-based vaccine against SARS-CoV-2 due to prothrombotic immunoglobulin…”
Get full text

Reassuring humoral and cellular immune responses to SARS-CoV-2 vaccination in participants with systemic sclerosis by Benoit, Jenna M., Breznik, Jessica A., Huynh, Angela, Cowbrough, Braeden, Baker, Barbara, Heessels, Lauren, Lodhi, Sumiya, Yan, Elizabeth, Bhakta, Hina, Clare, Rumi, Nazy, Ishac, Bramson, Jonathan L., Larché, Maggie J., Bowdish, Dawn ME

“…•Compared with controls, participants with SSc do not display weaker humoral responses following SARS-CoV-2 vaccination.•Participants with SSc and controls…”
Get full text

Antibody Responses to Third-Dose mRNA Vaccines in Nursing Home and Assisted Living Residents by Zhang, Ali, Breznik, Jessica A., Clare, Rumi, Nazy, Ishac, Miller, Matthew S., Bowdish, Dawn M.E., Costa, Andrew P.

Get full text

Early humoral and cellular responses after bivalent SARS‐CoV‐2 mRNA‐1273.214 vaccination in long‐term care and retirement home residents in Ontario, Canada: An observational cohort study by Breznik, Jessica A., Rahim, Ahmad, Bhakta, Hina, Clare, Rumi, Zhang, Ali, Ang, Jann, Stacey, Hannah D., Liu, Li‐Min, Kennedy, Allison, Bilaver, Lucas, Hagerman, Megan, Kajaks, Tara, Bramson, Jonathan L., Nazy, Ishac, Miller, Matthew S., Costa, Andrew P., Bowdish, Dawn M. E.

“…Immunogenicity of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) bivalent mRNA‐1273.214 vaccine (Original/Omicron B.1.1.529 [BA.1]) is…”
Get full text

Use of Anticoagulation in Patients with Immune Thrombocytopenia by Balitsky, Amaris K., Kelton, John G, Nazy, Ishac, Aubie, Brandon, Clare, Rumi, Jaffer, Anushka M, Arnold, Donald M

“…Introduction : There is little evidence to guide practice on the use of anticoagulation (AC) for patients with immune thrombocytopenia (ITP). In this study, we…”
Get full text

Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S by Huynh, Angela, Arnold, Donald M., Michael, James V., Clare, Rumi, Smith, James W., Daka, Mercy, Ianosi-Irimie, Monica, McKenzie, Steven E., Kelton, John G., Nazy, Ishac

Get full text