Search Results - "Clardy, J"

Total chemical synthesis of lassomycin and lassomycin-amide by Lear, S, Munshi, T, Hudson, A S, Hatton, C, Clardy, J, Mosely, J A, Bull, T J, Sit, C S, Cobb, S L

“…Herein we report a practical synthetic route to the lasso peptide lassomycin () and C-terminal variant lassomycin-amide (). The biological evaluation of…”
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FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases by Mojsilovic-Petrovic, Jelena, Nedelsky, Natalia, Boccitto, Marco, Mano, Itzhak, Georgiades, Savvas N, Zhou, Weiguo, Liu, Yuhong, Neve, Rachael L, Taylor, J. Paul, Driscoll, Monica, Clardy, Jon, Merry, Diane, Kalb, Robert G

“…Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress…”
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Pestalone, a New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge by Cueto, Mercedes, Jensen, Paul R, Kauffman, Chris, Fenical, William, Lobkovsky, Emil, Clardy, Jon

“…The isolation and structure determination of a new chlorinated benzophenone antibiotic, pestalone (1), is described. The new compound was produced by a…”
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The Guanacastepenes:  A Highly Diverse Family of Secondary Metabolites Produced by an Endophytic Fungus by Brady, Sean F, Bondi, Shana M, Clardy, Jon

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Dicerandrols, New Antibiotic and Cytotoxic Dimers Produced by the Fungus Phomopsis longicolla Isolated from an Endangered Mint by WAGENAAR, Melissa M., CLARDY, Jon

“…Bioassay-guided fractionation of the organic extract from a culture of Phomopsis longicolla, an endophytic fungus of the endangered mint Dicerandra frutescens,…”
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Long-Chain N-Acyl Amino Acid Antibiotics Isolated from Heterologously Expressed Environmental DNA by Brady, Sean F, Clardy, Jon

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Three New Cytochalasins Produced by an Endophytic Fungus in the Genus Rhinocladiella by Wagenaar, Melissa M, Corwin, Jennifer, Strobel, Gary, Clardy, Jon

“…Three new cytotoxic cytochalasins (1−3) and the previously reported cytochalasin E (4) were isolated from a culture of the endophytic fungus Rhinocladiella sp…”
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Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115 by Singh, M P, Janso, J E, Luckman, S W, Brady, S F, Clardy, J, Greenstein, M, Maiese, W M

“…Fermentation extracts of culture CR115, an unknown plant endophyte originally isolated from Costa Rica, were found to be active against antibiotic-resistant…”
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The Chemistry of Signal Transduction by Clardy, Jon

“…Several disciplines, including chemical ecology, seek to understand the molecular basis of information transfer in biological systems, and general molecular…”
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Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85 by Silo-Suh, L.A, Lethbridge, B.J, Raffel, S.J, He, H, Clardy, J, Handelsman, J

“…Cultures and culture filtrates of Bacillus cereus UW85 suppress damping-off of alfalfa caused by Phytophthora medicaginis. We studied the role in disease…”
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Differences in medical students' empathy by Newton, B W, Savidge, M A, Barber, L, Cleveland, E, Clardy, J, Beeman, G, Hart, T

“…Medical students' Balanced Emotional Empathy Scale scores were compared by year, sex, and expressed specialty choice. Scores were lower for students choosing…”
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Lessons from natural molecules by Clardy, Jon, Walsh, Christopher

“…Natural products have inspired chemists and physicians for millennia. Their rich structural diversity and complexity has prompted synthetic chemists to produce…”
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Production of kanosamine by Bacillus cereus UW85 by MILNER, J. L, SILO-SUH, L, LEE, J. C, HE, H, CLARDY, J, HANDELSMAN, J

“…Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Atomic Structure of the Trypsin−Aeruginosin 98-B Complex by Sandler, Benjamin, Murakami, Masahiro, Clardy, Jon

“…Murakami and co-workers discovered aeruginosin 98-A (R = Cl) and 98-B (R = H) (Chart 1) from the blue-green alga Microcystis aeruginosa using a protease…”
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Synthesis and Biological Evaluation of Analogues of the Antibiotic Pantocin B by Sutton, Amanda E, Clardy, Jon

“…Strains of the bacteria Erwinia herbicola produce antibiotics that effectively control E. amylovora, the bacterial pathogen responsible for the plant disease…”
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Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP by Cerione, Richard A, Nassar, Nicolas, Hoffman, Gregory R, Manor, Danny, Clardy, Jon C

“…The Rho-related small GTP-binding protein Cdc42 has a low intrinsic GTPase activity that is significantly enhanced by its specific GTPase-activating protein,…”
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Pestalotiopsins A and B:  New Caryophyllenes from an Endophytic Fungus of Taxus brevifolia by Pulici, Maurizio, Sugawara, Fumio, Koshino, Hiroyuki, Uzawa, Jun, Yoshida, Shigeo, Lobkovsky, Emil, Clardy, Jon

“…Two new caryophyllene sesquiterpenes have been isolated from Pestalotiopsis sp., an endophytic fungus associated with the bark and leaves of Taxus brevifolia…”
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Borrowing to Make Ends Meet by Clardy, Jon

“…New research by Briesewitz et al demonstrates yet another way to use organic chemistry to influence biological processes. Their research involves the part of…”
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The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease by Odagaki, Y, Hayashi, A, Okada, K, Hirotsu, K, Kabashima, T, Ito, K, Yoshimoto, T, Tsuru, D, Sato, M, Clardy, J

“…Background: The N-terminal pyroglutamyl (pGlu) residue of peptide hormones, such as thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing…”
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Structure of the PIN/LC8 dimer with a bound peptide by Clardy, Jon, Liang, Jun, Jaffrey, Samie R, Guo, Wei, Snyder, Solomon H

“…The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein…”
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