Search Results - "Clapp, Lucie"

The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors by Clapp, Lucie H., Gurung, Rijan

“…Pulmonary arterial hypertension (PAH) is a progressive disease of distal pulmonary arteries in which patients suffer from elevated pulmonary arterial pressure,…”
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Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist by Whittle, Brendan J., Silverstein, Adam M., Mottola, David M., Clapp, Lucie H.

“…Differential activation of human prostanoid receptors expressed in cells: EC50 values for prostacyclin analogues treprostinil or iloprost in stimulating…”
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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions by Norel, Xavier, Sugimoto, Yukihiko, Ozen, Gulsev, Abdelazeem, Heba, Amgoud, Yasmine, Bouhadoun, Amel, Bassiouni, Wesam, Goepp, Marie, Mani, Salma, Manikpurage, Hasanga D., Senbel, Amira, Longrois, Dan, Heinemann, Akos, Yao, Chengcan, Clapp, Lucie H.

“…Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI 2 ) and PGE 2 are…”
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International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E 2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions by Norel, Xavier, Sugimoto, Yukihiko, Ozen, Gulsev, Abdelazeem, Heba, Amgoud, Yasmine, Bouhadoun, Amel, Bassiouni, Wesam, Goepp, Marie, Mani, Salma, Manikpurage, Hasanga D, Senbel, Amira, Longrois, Dan, Heinemann, Akos, Yao, Chengcan, Clapp, Lucie H

“…Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI ) and PGE are…”
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Thomas (Tom) B. Bolton – a major force in smooth muscle research by Zholos, Alexander V., Greenwood, Iain A., Lang, Rick J., Benham, Christopher D., Aaronson, Philip I., Garland, Christopher J., Weston, Arthur H., Prestwich, Sally A., Gordienko, Dmitri V., Povstyan, Oleksandr V., Zhang, Hailin, Clapp, Lucie H., Pucovsky, Vladimir, Tare, Marianne, Fenech, Claire J., Unno, Toshihiro, Muraki, Katsuhiko, Shi, Jian, Hughes, Alun D., Halstead, Thomas K., Beech, David J.

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Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells by Patel, Jigisha A, Shen, Lei, Hall, Susan M, Benyahia, Chabha, Norel, Xavier, McAnulty, Robin J, Moledina, Shahin, Silverstein, Adam M, Whittle, Brendan J, Clapp, Lucie H

“…Prostacyclins are extensively used to treat pulmonary arterial hypertension (PAH), a life-threatening disease involving the progressive thickening of small…”
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Vasopressin: Mechanisms of action on the vasculature in health and in septic shock by Barrett, Lucinda K, Singer, Mervyn, Clapp, Lucie H

“…BACKGROUND:Vasopressin is essential for cardiovascular homeostasis, acting via the kidney to regulate water resorption, on the vasculature to regulate smooth…”
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Exploring the enzymatic degradation of poly(glycerol adipate) by Swainson, Sadie M.E., Taresco, Vincenzo, Pearce, Amanda K., Clapp, Lucie H., Ager, Barry, McAllister, Mark, Bosquillon, Cynthia, Garnett, Martin C.

“…[Display omitted] Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active…”
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Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension by FALCETTI, Emilia, HALL, Susan M, PHILLIPS, Peter G, PATEL, Jigisha, MORRELL, Nicholas W, HAWORTH, Sheila G, CLAPP, Lucie H

“…Prostacyclin analogs, used to treat idiopathic pulmonary arterial hypertension (IPAH), are assumed to work through prostacyclin (IP) receptors linked to cyclic…”
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Relative Recovery of Non-Alcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Rats by Aboujassoum, Hamda M, Mohamed-Ali, Vidya, Abraham, David, Clapp, Lucie H, Al-Naemi, Hamda A

“…Consumption of a high-carbohydrate diet has a critical role in the induction of weight gain and obesity-related pathologies. This study tested the hypothesis…”
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Prostacyclin mimetics inhibit DRP1-mediated pro-proliferative mitochondrial fragmentation in pulmonary arterial hypertension by Abu-Hanna, Jeries, Anastasakis, Evangelos, Patel, Jigisha A., Eddama, Mohammad Mahmoud Rajab, Denton, Christopher P., Taanman, Jan-Willem, Abraham, David, Clapp, Lucie H.

“…Pulmonary arterial hypertension (PAH) is a rare cardiopulmonary disorder, involving the remodelling of the small pulmonary arteries. Underlying this…”
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Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity by Raees, Asmaa, Bakhamis, Aysha, Mohamed-Ali, Vidya, Bashah, Moataz, Al-Jaber, Mashael, Abraham, David, Clapp, Lucie H., Orie, Nelson N.

“…Obesity is a risk factor for endothelial dysfunction, the severity of which is likely to vary depending on extent and impact of adiposity on the vasculature…”
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Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension by Ozen, Gulsev, Benyahia, Chabha, Mani, Salma, Boukais, Kamel, Silverstein, Adam M., Bayles, Richard, Nelsen, Andrew C., Castier, Yves, Danel, Claire, Mal, Hervé, Clapp, Lucie H., Longrois, Dan, Norel, Xavier

“…Background and Purpose In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone…”
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Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature by Abu-Hanna, Jeries, Patel, Jigisha A, Anastasakis, Evangelos, Cohen, Richard, Clapp, Lucie H, Loizidou, Marilena, Eddama, Mohammad M. R

“…Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C…”
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Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension by Shen, Lei, Patel, Jigisha A., Norel, Xavier, Moledina, Shahin, Whittle, Brendan J., von Kessler, Kirby, Sista, Prakash, Clapp, Lucie H.

“…[Display omitted] Beraprost is a prostacyclin analogue and IP receptor agonist which is approved to treat pulmonary arterial hypertension (PAH) in Asia. The…”
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Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension by Bubb, Kristen J, Trinder, Sarah L, Baliga, Reshma S, Patel, Jigisha, Clapp, Lucie H, MacAllister, Raymond J, Hobbs, Adrian J

“…BACKGROUND—Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary…”
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The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels by Cunningham, Kevin P., Clapp, Lucie H., Mathie, Alistair, Veale, Emma L.

“…Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin)…”
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Bronchodilation induced by PGE 2 is impaired in Group III pulmonary hypertension by Ozen, Gulsev, Benyahia, Chabha, Mani, Salma, Boukais, Kamel, Silverstein, Adam M, Bayles, Richard, Nelsen, Andrew C, Castier, Yves, Danel, Claire, Mal, Hervé, Clapp, Lucie H, Longrois, Dan, Norel, Xavier

“…In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is…”
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Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI₂ analogues in rat tail artery: Evidence for Gᵢ/ₒ modulation via EP₃ receptors by Orie, Nelson N, Clapp, Lucie H

“…Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI₂) analogues. However, these agents also activate prostanoid…”
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Interaction between PGI2 and ET-1 pathways in vascular smooth muscle from Group-III pulmonary hypertension patients by Ozen, Gulsev, Benyahia, Chabha, Amgoud, Yasmine, Patel, Jigisha, Abdelazeem, Heba, Bouhadoun, Amel, Yung, Sonia, Li, Fangfang, Mahieddine, Youcef, Silverstein, Adam M., Castier, Yves, Cazes, Aurélie, Longrois, Dan, Clapp, Lucie H., Norel, Xavier

“…•The ratio of ETA/ETB receptor expression is increased in pulmonary artery derived from Pulmonary Hypertension (PH) Group-III patients.•ETB receptor antagonist…”
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