Search Results - "Clapp, D"

Fanconi anaemia and cancer: an intricate relationship by Nalepa, Grzegorz, Clapp, D. Wade

“…Key Points Fanconi anaemia (FA) is a complex genetic syndrome associated with risk of congenital malformations, bone marrow failure and cancer. Diagnosis of FA…”
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Selumetinib in Children with Inoperable Plexiform Neurofibromas by Gross, Andrea M, Wolters, Pamela L, Dombi, Eva, Baldwin, Andrea, Whitcomb, Patricia, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Bornhorst, Miriam, Shah, Amish C, Martin, Staci, Roderick, Marie C, Pichard, Dominique C, Carbonell, Amanda, Paul, Scott M, Therrien, Janet, Kapustina, Oxana, Heisey, Kara, Clapp, D. Wade, Zhang, Chi, Peer, Cody J, Figg, William D, Smith, Malcolm, Glod, John, Blakeley, Jaishri O, Steinberg, Seth M, Venzon, David J, Doyle, L. Austin, Widemann, Brigitte C

“…Neurofibromatosis involves activation of the RAS pathway. Inhibition of MEK, a component of the pathway, with selumetinib was performed in 50 children with…”
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Fanconi Anemia Proteins Function in Mitophagy and Immunity by Sumpter, Rhea, Sirasanagandla, Shyam, Fernández, Álvaro F., Wei, Yongjie, Dong, Xiaonan, Franco, Luis, Zou, Zhongju, Marchal, Christophe, Lee, Ming Yeh, Clapp, D. Wade, Hanenberg, Helmut, Levine, Beth

“…Fanconi anemia (FA) pathway genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear DNA. Here, we describe an…”
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Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors by Bai, Ren-Yuan, Esposito, Dominic, Tam, Ada J., McCormick, Frank, Riggins, Gregory J., Wade Clapp, D., Staedtke, Verena

“…Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional…”
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Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma by Plotkin, Scott R, Duda, Dan G, Muzikansky, Alona, Allen, Jeffrey, Blakeley, Jaishri, Rosser, Tena, Campian, Jian L, Clapp, D Wade, Fisher, Michael J, Tonsgard, James, Ullrich, Nicole, Thomas, Coretta, Cutter, Gary, Korf, Bruce, Packer, Roger, Karajannis, Matthias A

“…Bevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing in approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and…”
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Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis by Liao, Chung-Ping, Booker, Reid C, Brosseau, Jean-Philippe, Chen, Zhiguo, Mo, Juan, Tchegnon, Edem, Wang, Yong, Clapp, D Wade, Le, Lu Q

“…Neurofibromatosis type 1 associates with multiple neoplasms, and the Schwann cell tumor neurofibroma is the most prevalent. A hallmark feature of neurofibroma…”
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A Flattening of the Curve: The Challenge of Disparate Growth Rates in the Pediatric Subspecialties by Vinci, Robert J., Clapp, D. Wade, Reed, Ann, Degnon, Laura

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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial by Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma…”
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Baseline Characteristics of Participants in the Randomized National Lung Screening Trial by Aberle, Denise R., Adams, Amanda M., Berg, Christine D., Clapp, Jonathan D., Clingan, Kathy L., Gareen, Ilana F., Lynch, David A., Marcus, Pamela M., Pinsky, Paul F.

“…Background The National Lung Screening Trial (NLST), a randomized study conducted at 33 US sites, is comparing lung cancer mortality among persons screened…”
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A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies by Maertens, Ophélia, McCurrach, Mila E, Braun, Benjamin S, De Raedt, Thomas, Epstein, Inbal, Huang, Tannie Q, Lauchle, Jennifer O, Lee, Hyerim, Wu, Jianqiang, Cripe, Timothy P, Clapp, D Wade, Ratner, Nancy, Shannon, Kevin, Cichowski, Karen

“…Preclinical studies using genetically engineered mouse models (GEMM) have the potential to expedite the development of effective new therapies; however, they…”
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Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation by Rhodes, Steven D, He, Yongzheng, Smith, Abbi, Jiang, Li, Lu, Qingbo, Mund, Julie, Li, Xiaohong, Bessler, Waylan, Qian, Shaomin, Dyer, William, Sandusky, George E, Horvai, Andrew E, Armstrong, Amy E, Clapp, D Wade

“…Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common…”
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Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up by Andriole, Gerald L., Crawford, E. David, Grubb, Robert L., Buys, Saundra S., Chia, David, Church, Timothy R., Fouad, Mona N., Isaacs, Claudine, Kvale, Paul A., Reding, Douglas J., Weissfeld, Joel L., Yokochi, Lance A., O'Brien, Barbara, Ragard, Lawrence R., Clapp, Jonathan D., Rathmell, Joshua M., Riley, Thomas L., Hsing, Ann W., Izmirlian, Grant, Pinsky, Paul F., Kramer, Barnett S., Miller, Anthony B., Gohagan, John K., Prorok, Philip C.

“…Background The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was undertaken to determine whether there is a…”
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Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo by Wang, Zhanxiang, Oh, Eunjin, Clapp, D. Wade, Chernoff, Jonathan, Thurmond, Debbie C.

“…The p21-activated kinase PAK1 is implicated in tumorigenesis, and efforts to inhibit PAK1 signaling as a means to induce tumor cell apoptosis are underway…”
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Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial by Robertson, Kent A, Dr, Nalepa, Grzegorz, MD, Yang, Feng-Chun, MD, Bowers, Daniel C, MD, Ho, Chang Y, MD, Hutchins, Gary D, Prof, Croop, James M, Prof, Vik, Terry A, MD, Denne, Scott C, Prof, Parada, Luis F, Prof, Hingtgen, Cynthia M, MD, Walsh, Laurence E, MD, Yu, Menggang, PhD, Pradhan, Kamnesh R, MD, Edwards-Brown, Mary K, Prof, Cohen, Mervyn D, Prof, Fletcher, James W, Prof, Travers, Jeffrey B, Prof, Staser, Karl W, PhD, Lee, Melissa W, BS, Sherman, Marcie R, BS, Davis, Cynthia J, RN, Miller, Lucy C, RN, Ingram, David A, Prof, Clapp, D Wade, Prof

“…Summary Background Plexiform neurofibromas are slow-growing chemoradiotherapy-resistant tumours arising in patients with neurofibromatosis type 1 (NF1)…”
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A molecular basis for neurofibroma-associated skeletal manifestations in NF1 by Ma, Yun, Gross, Andrea M., Dombi, Eva, Pemov, Alexander, Choi, Kwangmin, Chaney, Katherine, Rhodes, Steven D., Angus, Steven P., Sciaky, Noah, Clapp, D. Wade, Ratner, Nancy, Widemann, Brigitte C., Rios, Jonathan J., Elefteriou, Florent

“…Purpose Plexiform neurofibromas (pNF) develop in children with neurofibromatosis type 1 (NF1) and can be associated with several skeletal comorbidities…”
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Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase by Molosh, Andrei I, Johnson, Philip L, Spence, John P, Arendt, David, Federici, Lauren M, Bernabe, Cristian, Janasik, Steven P, Segu, Zaneer M, Khanna, Rajesh, Goswami, Chirayu, Zhu, Weiguo, Park, Su-Jung, Li, Lang, Mechref, Yehia S, Clapp, D Wade, Shekhar, Anantha

“…Neurofibromatosis type 1 (NF1) is associated with social dysfunction in children. Here the authors show that Nf1 heterozygous mice have deficits in social…”
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Mortality Results from a Randomized Prostate-Cancer Screening Trial by Andriole, Gerald L, Crawford, E. David, Grubb, Robert L, Buys, Saundra S, Chia, David, Church, Timothy R, Fouad, Mona N, Gelmann, Edward P, Kvale, Paul A, Reding, Douglas J, Weissfeld, Joel L, Yokochi, Lance A, O'Brien, Barbara, Clapp, Jonathan D, Rathmell, Joshua M, Riley, Thomas L, Hayes, Richard B, Kramer, Barnett S, Izmirlian, Grant, Miller, Anthony B, Pinsky, Paul F, Prorok, Philip C, Gohagan, John K, Berg, Christine D

“…In this study involving nearly 77,000 men, investigators analyzed the effect of screening with prostate-specific–antigen testing and digital rectal examination…”
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Mast cells and the neurofibroma microenvironment by Staser, Karl, Yang, Feng-Chun, Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) is the most common genetic disorder with a predisposition to malignancy and affects 1 in 3500 persons worldwide. NF1 is caused…”
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Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1 by Mund, Julie A, Park, SuJung, Smith, Abbi E, He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J, Mitchell, Dana K, Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K, Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D, Clapp, D Wade

“…Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the tumor suppressor gene. encodes neurofibromin, a…”
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PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2) by Hawley, Eric, Gehlhausen, Jeffrey, Karchugina, Sofiia, Chow, Hoi-Yee, Araiza-Olivera, Daniela, Radu, Maria, Smith, Abbi, Burks, Ciersten, Jiang, Li, Li, Xiaohong, Bessler, Waylan, Masters, Andrea, Edwards, Donna, Burgin, Callie, Jones, David, Yates, Charles, Clapp, D Wade, Chernoff, Jonathan, Park, Su-Jung

“…Abstract Neurofibromatosis Type II (NF2) is an autosomal dominant cancer predisposition syndrome in which germline haploinsufficiency at the NF2 gene confers a…”
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