Search Results - "Clapham, PR"

Rational modification of an HIV-1 gp120 results in enhanced neutralization breadth when used as a DNA prime by Wallace, A, Duenas-Decamp, MJ, Vaine, M, Peters, PJ, Wang, S, Clapham, PR, Lu, S

“…Doc number: P343…”
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The efficiency of bridging sheet recruitment determines HIV-1 R5 envelope sensitivity to soluble CD4 and macrophage tropism by O'Connell, O, Repik, A, Reeves, JD, Gonzalez-Perez, MP, Quitadamo, B, Duenas-Decamp, M, Peters, P, Lin, R, Anton, ED, Zolla-Pazner, S, Corti, D, Wallace, A, Wang, S, Kong, X, Lu, S, Clapham, PR

“…Doc number: P141…”
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Cell surface receptors, virus entry and tropism of primate lentiviruses by Clapham, Paul R, McKnight, Aine

“…Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech…”
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Biological Analysis of Human Immunodeficiency Virus Type 1 R5 Envelopes Amplified from Brain and Lymph Node Tissues of AIDS Patients with Neuropathology Reveals Two Distinct Tropism Phenotypes and Identifies Envelopes in the Brain That Confer an Enhanced Tropism and Fusigenicity for Macrophages by PETERS, Paul J, BHATTACHARYA, Jayanta, HIBBITTS, Samantha, DITTMAR, Matthias T, SIMMONS, Graham, BELL, Jeanne, SIMMONDS, Peter, CLAPHAM, Paul R

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A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry by Sabroe, I, Peck, M J, Van Keulen, B J, Jorritsma, A, Simmons, G, Clapham, P R, Williams, T J, Pease, J E

“…We describe a small molecule chemokine receptor antagonist, UCB35625 (the trans-isomer J113863 published by Banyu Pharmaceutical Co., patent WO98/04554), which…”
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Human Immunodeficiency Virus Type 1 Envelope Glycoproteins That Lack Cytoplasmic Domain Cysteines: Impact on Association with Membrane Lipid Rafts and Incorporation onto Budding Virus Particles by BHATTACHARYA, Jayanta, PETERS, Paul J, CLAPHAM, Paul R

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The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity by Proudfoot, Amanda E.I., Fritchley, Sarah, Borlat, Frédéric, Shaw, Jeffrey P., Vilbois, Francis, Zwahlen, Catherine, Trkola, Alexandra, Marchant, David, Clapham, Paul R., Wells, Timothy N.C.

“…The chemokine RANTES (regulated on activation normal T cell expressed and secreted; CCL5) binds selectively to glycosaminoglycans (GAGs) such as heparin,…”
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HIV-1 receptors and cell tropism by Clapham, Paul R, McKnight, Áine

“…HIV virus particles interact with several receptors on cell surfaces. Two receptors, CD4 and a co-receptor act sequentially to trigger fusion of viral and…”
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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity by Mack, M, Luckow, B, Nelson, P J, Cihak, J, Simmons, G, Clapham, P R, Signoret, N, Marsh, M, Stangassinger, M, Borlat, F, Wells, T N, Schlöndorff, D, Proudfoot, A E

“…CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal…”
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Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist by Simmons, Graham, Clapham, Paul R., Picard, Laurent, Offord, Robin E., Rosenkilde, Mette M., Schwartz, Thue W., Buser, Raphaële, Timothy N. C. Wells, Amanda E. I. Proudfoot

“…The chemokine receptors CXCR4 and CCR5 have recently been shown to act as coreceptors, in concert with CD4, for human immunodeficiency virus-type 1 (HIV-1)…”
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CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4 by Endres, Michael J, Clapham, Paul R, Marsh, Mark, Ahuja, Ména, Turner, Julie Davis, McKnight, Aine, Thomas, Jill F, Stoebenau-Haggarty, Beth, Choe, Sunny, Vance, Patricia J, Wells, Timothy N.C, Power, Christine A, Sutterwala, Shaheen S, Doms, Robert W, Landau, Nathaniel R, Hoxie, James A

“…Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the…”
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The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes by NEIL, Stuart J. D, AASA-CHAPMAN, Marlen M. I, CLAPHAM, Paul R, NIBBS, Robert J, MCKNIGHT, Aine, WEISS, Robin A

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Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry by Simmons, G, Wilkinson, D, Reeves, J D, Dittmar, M T, Beddows, S, Weber, J, Carnegie, G, Desselberger, U, Gray, P W, Weiss, R A, Clapham, P R

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Co-receptor use by HIV and inhibition of HIV infection by chemokine receptor ligands by Simmons, Graham, Reeves, Jacqueline D., Hibbitts, Sam, Stine, Johnny T., Gray, Patrick W., Proudfoot, Amanda E. I., Clapham, Paul R.

“…Human and simian immunodeficiency viruses (HIV and SIV) require a seven transmembrane chemokine (7TM) receptor in addition to CD4 for efficient entry into…”
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Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo by Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, Clapham, Paul R.

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Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses by Willet, B.J. (University of Glasgow Veterinary School, Glasgow.), Picard, L, Hosie, M.J, Turner, J.D, Adema, K, Clapham, P.R

“…Feline immunodeficiency virus (FIV) induces a disease state in the domestic cat that is similar to AIDS in human immunodeficiency virus (HIV)-infected…”
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CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages by Simmons, G, Reeves, J D, McKnight, A, Dejucq, N, Hibbitts, S, Power, C A, Aarons, E, Schols, D, De Clercq, E, Proudfoot, A E, Clapham, P R

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Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent by McKnight, A, Wilkinson, D, Simmons, G, Talbot, S, Picard, L, Ahuja, M, Marsh, M, Hoxie, J A, Clapham, P R

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Immunodeficiency viruses Spoilt for choice of co-receptors by Clapham, Paul R, Weiss, Robin A

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CD4-dependent and CD4-independent HIV-2: consequences for neutralization by THOMAS, Elaine R, SHOTTON, Christine, WEISS, Robin A, CLAPHAM, Paul R, MCKNIGHT, Aine

“…HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-2, including primary isolates, can infect cells independently of CD4. To…”
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