Search Results - "Clancy, S."

Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1–2 trial by Shaw, Alice T, Solomon, Benjamin J, Chiari, Rita, Riely, Gregory J, Besse, Benjamin, Soo, Ross A, Kao, Steven, Lin, Chia-Chi, Bauer, Todd M, Clancy, Jill S, Thurm, Holger, Martini, Jean-Francois, Peltz, Gerson, Abbattista, Antonello, Li, Sherry, Ou, Sai-Hong Ignatius

“…Lorlatinib is a potent, brain-penetrant, third-generation tyrosine kinase inhibitor (TKI) that targets ALK and ROS1 with preclinical activity against most…”
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ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer by Shaw, Alice T, Solomon, Benjamin J, Besse, Benjamin, Bauer, Todd M, Lin, Chia-Chi, Soo, Ross A, Riely, Gregory J, Ou, Sai-Hong Ignatius, Clancy, Jill S, Li, Sherry, Abbattista, Antonello, Thurm, Holger, Satouchi, Miyako, Camidge, D Ross, Kao, Steven, Chiari, Rita, Gadgeel, Shirish M, Felip, Enriqueta, Martini, Jean-François

“…Lorlatinib is a potent, brain-penetrant, third-generation anaplastic lymphoma kinase (ALK)/ROS1 tyrosine kinase inhibitor (TKI) with robust clinical activity…”
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SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters by Port, Julia R., Yinda, Claude Kwe, Owusu, Irene Offei, Holbrook, Myndi, Fischer, Robert, Bushmaker, Trenton, Avanzato, Victoria A., Schulz, Jonathan E., Martens, Craig, van Doremalen, Neeltje, Clancy, Chad S., Munster, Vincent J.

“…Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject…”
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Reconciling food security and bioenergy: priorities for action by Kline, Keith L., Msangi, Siwa, Dale, Virginia H., Woods, Jeremy, Souza, Glaucia M., Osseweijer, Patricia, Clancy, Joy S., Hilbert, Jorge A., Johnson, Francis X., McDonnell, Patrick C., Mugera, Harriet K.

“…Understanding the complex interactions among food security, bioenergy sustainability, and resource management requires a focus on specific contextual problems…”
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The potential for spills and leaks of contaminated liquids from shale gas developments by Clancy, S.A., Worrall, F., Davies, R.J., Gluyas, J.G.

“…Rapid growth of hydraulic fracturing for shale gas within the USA and the possibility of shale developments within Europe has created public concern about the…”
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Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial by Younes, Anas, Dr, Berdeja, Jesus G, MD, Patel, Manish R, MD, Flinn, Ian, MD, Gerecitano, John F, MD, Neelapu, Sattva S, MD, Kelly, Kevin R, MD, Copeland, Amanda R, MSN, Akins, Amy, BSN, Clancy, Myles S, MBA, Gong, Lucy, PharmD, Wang, Jing, PhD, Ma, Anna, MS, Viner, Jaye L, MD, Oki, Yasuhiro, MD

“…Summary Background Treatment options for patients with relapsed or refractory lymphoma and multiple myeloma are limited. CUDC-907 is an oral, first-in-class,…”
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Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteins by O’Donnell, Kyle L., Gourdine, Tylisha, Fletcher, Paige, Clancy, Chad S., Marzi, Andrea

“…Successful vaccine efforts countering the COVID-19 pandemic are centralized around the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)…”
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Systemic bevacizumab for high-output cardiac failure in hereditary hemorrhagic telangiectasia: an international survey of HHT centers by Al-Samkari, Hanny, Albitar, Hasan A, Olitsky, Scott E, Clancy, Marianne S, Iyer, Vivek N

“…Systemic bevacizumab is a novel targeted anti-angiogenic therapy for high-output cardiac failure (HOCF) in hereditary hemorrhagic telangiectasia (HHT) but…”
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Brain and lung arteriovenous malformation rescreening practices for children and adults with hereditary hemorrhagic telangiectasia by Beslow, Lauren A, Kim, Helen, Hetts, Steven W, Ratjen, Felix, Clancy, Marianne S, Gossage, James R, Faughnan, Marie E

“…We surveyed North American HHT CoEs regarding rescreening practices for new brain and lung AVMs in children and adults with initial negative screening. All…”
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Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2 by Hilligan, Kerry L., Namasivayam, Sivaranjani, Clancy, Chad S., Baker, Paul J., Old, Samuel I., Peluf, Victoria, Amaral, Eduardo P., Oland, Sandra D., O’Mard, Danielle, Laux, Julie, Cohen, Melanie, Garza, Nicole L., Lafont, Bernard A. P., Johnson, Reed F., Feng, Carl G., Jankovic, Dragana, Lamiable, Olivier, Mayer-Barber, Katrin D., Sher, Alan

“…Type-1 and type-3 interferons (IFNs) are important for control of viral replication; however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral…”
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An assessment of the footprint and carrying capacity of oil and gas well sites: The implications for limiting hydrocarbon reserves by Clancy, S.A., Worrall, F., Davies, R.J., Gluyas, J.G.

“…We estimate the likely physical footprint of well pads if shale gas or oil developments were to go forward in Europe and used these estimates to understand…”
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Pathogenic differences of cynomolgus macaques after Taï Forest virus infection depend on the viral stock propagation by Fletcher, Paige, Clancy, Chad S, O'Donnell, Kyle L, Doratt, Brianna M, Malherbe, Delphine C, Rhoderick, Joseph F, Feldmann, Friederike, Hanley, Patrick W, Takada, Ayato, Messaoudi, Ilhem, Marzi, Andrea

“…Taï Forest virus (TAFV) is a negative-sense RNA virus in the Filoviridae family. TAFV has caused only a single human infection, but several disease outbreaks…”
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Contribution of Acute Kidney Injury Toward Morbidity and Mortality in Burns: A Contemporary Analysis by Coca, Steven G., DO, Bauling, Paul, MD, Schifftner, Tracy, MS, Howard, Clancy S., MD, Teitelbaum, Isaac, MD, Parikh, Chirag R., MD, PhD

“…Background Severe acute kidney injury (AKI) that requires dialytic support, a relatively uncommon complication in severely burned adults, is associated with a…”
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Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19 by Robertson, Shelly J., Bedard, Olivia, McNally, Kristin L., Shaia, Carl, Clancy, Chad S., Lewis, Matthew, Broeckel, Rebecca M., Chiramel, Abhilash I., Shannon, Jeffrey G., Sturdevant, Gail L., Rosenke, Rebecca, Anzick, Sarah L., Forte, Elvira, Preuss, Christoph, Baker, Candice N., Harder, Jeffrey M., Brunton, Catherine, Munger, Steven, Bruno, Daniel P., Lack, Justin B., Leung, Jacqueline M., Shamsaddini, Amirhossein, Gardina, Paul, Sturdevant, Daniel E., Sun, Jian, Martens, Craig, Holland, Steven M., Rosenthal, Nadia A., Best, Sonja M.

“…Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and…”
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Optimization of Single-Dose VSV-Based COVID-19 Vaccination in Hamsters by O'Donnell, Kyle L, Clancy, Chad S, Griffin, Amanda J, Shifflett, Kyle, Gourdine, Tylisha, Thomas, Tina, Long, Carrie M, Furuyama, Wakako, Marzi, Andrea

“…The ongoing COVID-19 pandemic has resulted in global effects on human health, economic stability, and social norms. The emergence of viral variants raises…”
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Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease by Monath, Thomas P., Nichols, Richard, Feldmann, Friederike, Griffin, Amanda, Haddock, Elaine, Callison, Julie, Meade-White, Kimberly, Okumura, Atsushi, Lovaglio, Jamie, Hanley, Patrick W., Clancy, Chad S., Shaia, Carl, Rida, Wasima, Fusco, Joan

“…IntroductionImmune correlates of protection afforded by PHV02, a recombinant vesicular stomatitis (rVSV) vector vaccine against Nipah virus (NiV) disease, were…”
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Rapid Protection from COVID-19 in Nonhuman Primates Vaccinated Intramuscularly but Not Intranasally with a Single Dose of a Vesicular Stomatitis Virus-Based Vaccine by Furuyama, Wakako, Shifflett, Kyle, Pinski, Amanda N, Griffin, Amanda J, Feldmann, Friederike, Okumura, Atsushi, Gourdine, Tylisha, Jankeel, Allen, Lovaglio, Jamie, Hanley, Patrick W, Thomas, Tina, Clancy, Chad S, Messaoudi, Ilhem, O'Donnell, Kyle L, Marzi, Andrea

“…The ongoing pandemic of coronavirus (CoV) disease 2019 (COVID-19) continues to exert a significant burden on health care systems worldwide. With limited…”
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Camelid Inoculation With Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection by Adney, Danielle R, Clancy, Chad S, Bowen, Richard A, Munster, Vincent J

“…Within the past two decades, three zoonotic betacoronaviruses have been associated with outbreaks causing severe respiratory disease in humans. Of these,…”
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Zika virus vertical transmission in interferon receptor1-antagonized Rag1 -/- mice results in postnatal brain abnormalities and clinical disease by Winkler, Clayton W, Clancy, Chad S, Rosenke, Rebecca, Peterson, Karin E

“…The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain poorly…”
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Understanding the expansion of energy crops beyond the global biofuel boom: evidence from oil palm expansion in Colombia by Marin-Burgos, Victoria, Clancy, Joy S.

“…Background The global palm oil market experienced a remarkable boom since the year 2000. Since palm oil can be used for biodiesel production, the global…”
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