Search Results - "Clancy, Robert M."

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity by Sisirak, Vanja, Sally, Benjamin, D’Agati, Vivette, Martinez-Ortiz, Wilnelly, Özçakar, Z. Birsin, David, Joseph, Rashidfarrokhi, Ali, Yeste, Ada, Panea, Casandra, Chida, Asiya Seema, Bogunovic, Milena, Ivanov, Ivaylo I., Quintana, Francisco J., Sanz, Inaki, Elkon, Keith B., Tekin, Mustafa, Yalçınkaya, Fatoş, Cardozo, Timothy J., Clancy, Robert M., Buyon, Jill P., Reizis, Boris

“…Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted…”
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Evaluation of Immune Response and Disease Status in Systemic Lupus Erythematosus Patients Following SARS–CoV‐2 Vaccination by Izmirly, Peter M., Kim, Mimi Y., Samanovic, Marie, Fernandez‐Ruiz, Ruth, Ohana, Sharon, Deonaraine, Kristina K., Engel, Alexis J., Masson, Mala, Xie, Xianhong, Cornelius, Amber R., Herati, Ramin S., Haberman, Rebecca H., Scher, Jose U., Guttmann, Allison, Blank, Rebecca B., Plotz, Benjamin, Haj‐Ali, Mayce, Banbury, Brittany, Stream, Sara, Hasan, Ghadeer, Ho, Gary, Rackoff, Paula, Blazer, Ashira D., Tseng, Chung‐E, Belmont, H. Michael, Saxena, Amit, Mulligan, Mark J., Clancy, Robert M., Buyon, Jill P.

“…Objective To evaluate seroreactivity and disease flares after COVID‐19 vaccination in a multiethnic/multiracial cohort of patients with systemic lupus…”
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Endosomal Toll-like receptors in clinically overt and silent autoimmunity by Clancy, Robert M., Markham, Androo J., Buyon, Jill P.

“…Summary Toll‐like receptors (TLRs), first identified as pattern recognition receptors, are now recognized to serve as a key interface between innate and…”
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Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic lupus erythematosus patients by Blazer, Ashira, Wang, Binhuan, Simpson, Danny, Kirchhoff, Tomas, Heffron, Sean, Clancy, Robert M, Heguy, Adriana, Ray, Karina, Snuderl, Matija, Buyon, Jill P

“…Atherosclerosis is exaggerated in African American (AA) systemic lupus erythematosus (SLE) patients, with doubled cardiovascular disease (CVD) risk compared to…”
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APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress by Blazer, Ashira, Qian, Yingzhi, Schlegel, Martin Paul, Algasas, Huda, Buyon, Jill P, Cadwell, Ken, Cammer, Michael, Heffron, Sean P, Liang, Feng-Xia, Mehta-Lee, Shilpi, Niewold, Timothy, Rasmussen, Sara E, Clancy, Robert M

“…Polymorphisms in the Apolipoprotein L1 ( ) gene are common in ancestrally African populations, and associate with kidney injury and cardiovascular disease…”
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Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis by Hardt, Uta, Larsson, Anders, Gunnarsson, Iva, Clancy, Robert M, Petri, Michelle, Buyon, Jill P, Silverman, Gregg J, Svenungsson, Elisabet, Grönwall, Caroline

“…Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have…”
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Serum Biomarkers of Inflammation, Fibrosis, and Cardiac Function in Facilitating Diagnosis, Prognosis, and Treatment of Anti-SSA/Ro–Associated Cardiac Neonatal Lupus by Saxena, Amit, MD, Izmirly, Peter M., MD, Han, Sung Won, PhD, Briassouli, Paraskevi, PhD, Rivera, Tania L., MD, Zhong, Hua, PhD, Friedman, Deborah M., MD, Clancy, Robert M., PhD, Buyon, Jill P., MD

“…Abstract Background Cardiac manifestations of neonatal lupus (cardiac NL) include congenital heart block and cardiomyopathy. Several candidate biomarkers were…”
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Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside by Buyon, Jill P, Clancy, Robert M, Friedman, Deborah M

“…One of the strongest clinical associations with autoantibodies against components of the SSA/Ro-SSB/La ribonucleoprotein complex is the development of…”
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Gut dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus by Clancy, Robert M., Marion, Miranda C., Ainsworth, Hannah C., Chang, Miao, Howard, Timothy D., Izmirly, Peter M., Masson, Mala, Buyon, Jill P., Langefeld, Carl D.

“…Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from…”
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Circulating endothelial cells. Biomarker of vascular disease by Blann, Andrew D, Woywodt, Alexander, Bertolini, Francesco, Bull, Todd M, Buyon, Jill P, Clancy, Robert M, Haubitz, Marion, Hebbel, Robert P, Lip, Gregory Y H, Mancuso, Patrizia, Sampol, Jose, Solovey, Anna, Dignat-George, Françoise

“…Recent research has recognised new populations of non-hematopoietic cells in the blood. One of these, circulating endothelial cells (CECs), often defined by…”
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The modifying influence of HLA class II DQB1∗06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+ mothers of children with neonatal lupus by Clancy, Robert M., Guthridge, Carla J., Marion, Miranda C., Guthridge, Joel, Howard, Timothy D., Izmirly, Peter M., Masson, Mala, Buyon, Jill P., James, Judith A., Langefeld, Carl D.

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Reactivity to the p305 Epitope of the α1G T‐Type Calcium Channel and Autoimmune‐Associated Congenital Heart Block by Markham, Androo J., Rasmussen, Sara E., Salmon, Jane E., Martinez‐Ortiz, Wilnelly, Cardozo, Timothy J., Clancy, Robert M., Buyon, Jill P.

“…Background Only 2% of mothers positive for anti‐SSA/Ro (Ro) antibodies have children with congenital heart block (CHB). This study aimed to determine whether…”
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Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block by Clancy, Robert M, Halushka, Marc, Rasmussen, Sara E, Lhakhang, Tenzin, Chang, Miao, Buyon, Jill P

“…Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of…”
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Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus by Hartl, Johannes, Serpas, Lee, Wang, Yueyang, Rashidfarrokhi, Ali, Perez, Oriana A, Sally, Benjamin, Sisirak, Vanja, Soni, Chetna, Khodadadi-Jamayran, Alireza, Tsirigos, Aristotelis, Caiello, Ivan, Bracaglia, Claudia, Volpi, Stefano, Ghiggeri, Gian Marco, Chida, Asiya Seema, Sanz, Ignacio, Kim, Mimi Y, Belmont, H Michael, Silverman, Gregg J, Clancy, Robert M, Izmirly, Peter M, Buyon, Jill P, Reizis, Boris

“…Antibodies to double-stranded DNA (dsDNA) are prevalent in systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis, yet the nature…”
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High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis by Iwamoto, Taro, Dorschner, Jessica M, Selvaraj, Shanmugapriya, Mezzano, Valeria, Jensen, Mark A, Vsetecka, Danielle, Amin, Shreyasee, Makol, Ashima, Osborn, Thomas, Moder, Kevin, Chowdhary, Vaidehi R, Izmirly, Peter, Belmont, H Michael, Clancy, Robert M, Buyon, Jill P, Wu, Ming, Loomis, Cynthia A, Niewold, Timothy B

“…Previous studies suggest a link between high serum type I interferon (IFN) and lupus nephritis (LN). We determined whether serum IFN activity is associated…”
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Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti‐SSA/Ro Pregnancies by Buyon, Jill. P., Masson, Mala, Izmirly, Caroline G., Phoon, Colin, Acherman, Ruben, Sinkovskaya, Elena, Abuhamad, Alfred, Makhoul, Majd, Satou, Gary, Hogan, Whitnee, Pinto, Nelangi, Moon‐Grady, Anita, Howley, Lisa, Donofrio, Mary, Krishnan, Anita, Ahmadzia, Homa, Levasseur, Stephanie, Paul, Erin, Owens, Sonal, Cumbermack, Kristopher, Matta, Jyothi, Joffe, Gary, Lindblade, Christopher, Haxel, Caitlin, Kohari, Katherine, Copel, Joshua, Strainic, James, Doan, Tam, Bermudez‐Wagner, Karla, Holloman, Conisha, Sheth, Shreya S., Killen, Stacy, Tacy, Theresa, Kaplinski, Michelle, Hornberger, Lisa, Carlucci, Philip M., Izmirly, Peter, Fraser, Nicola, Clancy, Robert M., Cuneo, Bettina F.

“…Objective This prospective study of pregnant patients, Surveillance To Prevent AV Block Likely to Occur Quickly (STOP BLOQ), addresses the impact of…”
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Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block by Clancy, Robert M, Markham, Androo J, Jackson, Tanisha, Rasmussen, Sara E, Blumenberg, Miroslav, Buyon, Jill P

“…The signature lesion of SSA/Ro autoantibody-associated congenital heart block (CHB) is fibrosis and a macrophage infiltrate, supporting an experimental focus…”
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A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity by Shipman, William D, Chyou, Susan, Ramanathan, Anusha, Izmirly, Peter M, Sharma, Sneh, Pannellini, Tania, Dasoveanu, Dragos C, Qing, Xiaoping, Magro, Cynthia M, Granstein, Richard D, Lowes, Michelle A, Pamer, Eric G, Kaplan, Daniel H, Salmon, Jane E, Mehrara, Babak J, Young, James W, Clancy, Robert M, Blobel, Carl P, Lu, Theresa T

“…Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus and other autoimmune and dermatologic conditions, but…”
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Ro60-Associated Single-Stranded RNA Links Inflammation with Fetal Cardiac Fibrosis via Ligation of TLRs: A Novel Pathway to Autoimmune-Associated Heart Block by Clancy, Robert M, Alvarez, David, Komissarova, Elena, Barrat, Franck J, Swartz, Jordan, Buyon, Jill P

“…Activation of TLR by ssRNA after FcgammaR-mediated phagocytosis of immune complexes (IC) may be relevant in autoimmune-associated congenital heart block (CHB)…”
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Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus by Reed, Joanne H, Sim, Soyeong, Wolin, Sandra L, Clancy, Robert M, Buyon, Jill P

“…Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targeting an intracellular ribonucleoprotein, Ro60, which binds noncoding Y RNA and…”
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