Search Results - "Clair, Joshua R. St"

Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate by Larson, Eric D., St. Clair, Joshua R., Sumner, Whitney A., Bannister, Roger A., Proenza, Cathy

“…An inexorable decline in maximum heart rate (mHR) progressively limits human aerobic capacity with advancing age. This decrease in mHR results from an…”
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Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction by St Clair, Joshua R, Westacott, Matthew J, Miranda, Jose, Farnsworth, Nikki L, Kravets, Vira, Schleicher, Wolfgang E, Dwulet, JaeAnn M, Levitt, Claire H, Heintz, Audrey, Ludin, Nurin W F, Benninger, Richard K P

“…The secretion of insulin from β-cells in the islet of Langerhans is governed by a series of metabolic and electrical events, which can fail during the…”
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Culture and adenoviral infection of sinoatrial node myocytes from adult mice by St Clair, Joshua R, Sharpe, Emily J, Proenza, Catherine

“…Pacemaker myocytes in the sinoatrial node of the heart initiate each heartbeat by firing spontaneous action potentials. However, the molecular processes that…”
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Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4 by Liao, Zhandi, Lockhead, Dean, St Clair, Joshua R, Larson, Eric D, Wilson, Courtney E, Proenza, Catherine

“…Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels produce the I(f) and I(h) currents, which are critical for cardiac pacemaking and…”
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Age-Dependent Decline in the Coordinated [Ca 2+ ] and Insulin Secretory Dynamics in Human Pancreatic Islets by Westacott, Matthew J, Farnsworth, Nikki L, St Clair, Joshua R, Poffenberger, Greg, Heintz, Audrey, Ludin, Nurin W, Hart, Nathaniel J, Powers, Alvin C, Benninger, Richard K P

“…Aging is associated with increased risk for type 2 diabetes, resulting from reduced insulin sensitivity and secretion. Reduced insulin secretion can result…”
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Contrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models by St Clair, Joshua R., Ramirez, David, Passman, Samantha, Benninger, Richard K. P.

“…In type 1 diabetes (T1D), immune-cell infiltration into the islets of Langerhans (insulitis) and β-cell decline occurs many years before diabetes clinically…”
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Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice by Sharpe, Emily J, St Clair, Joshua R, Proenza, Catherine

“…Sinoatrial node myocytes (SAMs) act as the natural pacemakers of the heart, initiating each heart beat by generating spontaneous action potentials (APs). These…”
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Contemporary Predictors of Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention: A Nationally Representative US Sample by Horne, Benjamin D, Atreja, Nipun, Venditto, John, Wilson, Thomas, Muhlestein, Joseph B, St Clair, Joshua R, Knowlton, Kirk U, Khan, Naeem D, Bhalla, Narinder, Anderson, Jeffrey L

“…: Patient outcomes after percutaneous coronary intervention (PCI) have improved over the last 30 years due to better techniques, therapies, and care processes…”
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Myristoylated peptides potentiate the funny current (If) in sinoatrial myocytes by Liao, Zhandi, St. Clair, Joshua R., Larson, Eric D., Proenza, Catherine

“…The funny current, I f , in sinoatrial myocytes is thought to contribute to the sympathetic fight-or-flight increase in heart rate. I f is produced by…”
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Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes by St. Clair, Joshua, Larson, Eric, Sharpe, Emily, Liao, Zhandi, Proenza, Catherine

“…Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial…”
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Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, I f , in Mouse Sinoatrial Node Myocytes by St Clair, Joshua R, Larson, Eric D, Sharpe, Emily J, Liao, Zhandi, Proenza, Catherine

“…Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3',5'-cyclic adenosine monophosphate) signaling in sinoatrial…”
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PKA-independent activation of If by cAMP in mouse sinoatrial myocytes by St Clair, Joshua R, Liao, Zhandi, Larson, Eric D, Proenza, Catherine

“…Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN4) channels produce the "funny current," I f , which contributes to spontaneous pacemaking in…”
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PKA-independent activation of I f by cAMP in mouse sinoatrial myocytes by St Clair, Joshua R, Liao, Zhandi, Larson, Eric D, Proenza, Catherine

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Dynamic regulation of pacemaker activity by the Na+-K+ pump by Morotti, Stefano, St. Clair, Joshua R., Proenza, Catherine, Grandi, Eleonora

“…The role of Na + homeostasis in cardiac pacemaking is not well established. Blocking of the Na + -K + ATPase (NKA) to raise intracellular Na + concentration…”
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Different Effects of Alkaline Phosphatase on HCN4 Channels in CHO Versus HEK Cells by Juchno, Julie, St Clair, Joshua R., Proenza, Cathy

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Mammalian γ2 AMPK regulates intrinsic heart rate by Yavari, Arash, Bellahcene, Mohamed, Bucchi, Annalisa, Sirenko, Syevda, Pinter, Katalin, Herring, Neil, Jung, Julia J., Tarasov, Kirill V., Sharpe, Emily J., Wolfien, Markus, Czibik, Gabor, Steeples, Violetta, Ghaffari, Sahar, Nguyen, Chinh, Stockenhuber, Alexander, Clair, Joshua R. St, Rimmbach, Christian, Okamoto, Yosuke, Yang, Dongmei, Wang, Mingyi, Ziman, Bruce D., Moen, Jack M., Riordon, Daniel R., Ramirez, Christopher, Paina, Manuel, Lee, Joonho, Zhang, Jing, Ahmet, Ismayil, Matt, Michael G., Tarasova, Yelena S., Baban, Dilair, Sahgal, Natasha, Lockstone, Helen, Puliyadi, Rathi, de Bono, Joseph, Siggs, Owen M., Gomes, John, Muskett, Hannah, Maguire, Mahon L., Beglov, Youlia, Kelly, Matthew, dos Santos, Pedro P. N., Bright, Nicola J., Woods, Angela, Gehmlich, Katja, Isackson, Henrik, Douglas, Gillian, Ferguson, David J. P., Schneider, Jürgen E., Tinker, Andrew, Wolkenhauer, Olaf, Channon, Keith M., Cornall, Richard J., Sternick, Eduardo B., Paterson, David J., Redwood, Charles S., Carling, David, Proenza, Catherine, David, Robert, Baruscotti, Mirko, DiFrancesco, Dario, Lakatta, Edward G., Watkins, Hugh, Ashrafian, Houman

“…AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ…”
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Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice by Sharpe, Emily J., St. Clair, Joshua R., Proenza, Catherine

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Diabetes Slows Heart Rate via Electrical Remodeling of K+ Currents in Sinoatrial Node Myocytes by St. Clair, Joshua R., Sharpe, Emily J., Hagar, Andrew, Garthe, Clayton, Juchno, Julie, Proenza, Cathy

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PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes by St Clair, Joshua R, Liao, Zhandi, Larson, Eric D, Proenza, Catherine

“…Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN4) channels produce the "funny current," I(f), which contributes to spontaneous pacemaking in…”
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