Search Results - "Clair, David St"

Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease by Lathe, Richard, St. Clair, David

“…ABSTRACT The characteristic maximum lifespan varies enormously across animal species from a few hours to hundreds of years. This argues that maximum lifespan,…”
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Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity by Yoon, Ki-Jun, Nguyen, Ha Nam, Ursini, Gianluca, Zhang, Fengyu, Kim, Nam-Shik, Wen, Zhexing, Makri, Georgia, Nauen, David, Shin, Joo Heon, Park, Youngbin, Chung, Raeeun, Pekle, Eva, Zhang, Ce, Towe, Maxwell, Hussaini, Syed Mohammed Qasim, Lee, Yohan, Rujescu, Dan, St. Clair, David, Kleinman, Joel E., Hyde, Thomas M., Krauss, Gregory, Christian, Kimberly M., Rapoport, Judith L., Weinberger, Daniel R., Song, Hongjun, Ming, Guo-li

“…Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has…”
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Using mouse transgenic and human stem cell technologies to model genetic mutations associated with schizophrenia and autism by St. Clair, David, Johnstone, Mandy

“…Solid progress has occurred over the last decade in our understanding of the molecular genetic basis of neurodevelopmental disorders, and of schizophrenia and…”
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Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy by Benson, Philip J, Beedie, Sara A, Shephard, Elizabeth, Giegling, Ina, Rujescu, Dan, St. Clair, David

“…Background We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their…”
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From conifers to cognition: Microbes, brain and behavior by Lathe, Richard, St. Clair, David

“…A diversity of bacteria, protozoans and viruses (“endozoites”) were recently uncovered within healthy tissues including the human brain. By contrast, it was…”
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Synaptic scaffold evolution generated components of vertebrate cognitive complexity by Nithianantharajah, Jess, Komiyama, Noboru H, McKechanie, Andrew, Johnstone, Mandy, Blackwood, Douglas H, Clair, David St, Emes, Richard D, van de Lagemaat, Louie N, Saksida, Lisa M, Bussey, Timothy J, Grant, Seth G N

“…In this paper, the authors show that mice lacking Dlg genes each show distinct deficits in various learning paradigms. In addition, they find that humans with…”
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Atypical Scanpaths in Schizophrenia: Evidence of A Trait- Or State-Dependent Phenomenon? by Beedie, Sara A., PhD, Benson, Philip J., PhD, St. Clair, David M., MD, PhD

“…The development of trait markers of schizophrenia would represent an important advance in understanding the genetic architecture of the disease. To date, no…”
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A machine learning case–control classifier for schizophrenia based on DNA methylation in blood by Gunasekara, Chathura J., Hannon, Eilis, MacKay, Harry, Coarfa, Cristian, McQuillin, Andrew, Clair, David St, Mill, Jonathan, Waterland, Robert A.

“…Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but the cell type-specificity of DNA methylation makes…”
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Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia by Kim, Ju Young, Liu, Cindy Y., Zhang, Fengyu, Duan, Xin, Wen, Zhexing, Song, Juan, Feighery, Emer, Lu, Bai, Rujescu, Dan, St Clair, David, Christian, Kimberly, Callicott, Joseph H., Weinberger, Daniel R., Song, Hongjun, Ming, Guo-li

“…How extrinsic stimuli and intrinsic factors interact to regulate continuous neurogenesis in the postnatal mammalian brain is unknown. Here we show that…”
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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder by Sklar, Pamela, Craddock, Nick, Ferreira, Manuel A R, O'Donovan, Michael C, Meng, Yan A, Jones, Ian R, Ruderfer, Douglas M, Jones, Lisa, Fan, Jinbo, Kirov, George, Perlis, Roy H, Green, Elaine K, Smoller, Jordan W, Grozeva, Detelina, Stone, Jennifer, Nikolov, Ivan, Chambert, Kimberly, Hamshere, Marian L, Nimgaonkar, Vishwajit L, Moskvina, Valentina, Thase, Michael E, Caesar, Sian, Sachs, Gary S, Franklin, Jennifer, Gordon-Smith, Katherine, Ardlie, Kristin G, Gabriel, Stacey B, Fraser, Christine, Blumenstiel, Brendan, Defelice, Matthew, Breen, Gerome, Gill, Michael, Morris, Derek W, Elkin, Amanda, Muir, Walter J, McGhee, Kevin A, Williamson, Richard, MacIntyre, Donald J, MacLean, Alan W, St Clair, David, Robinson, Michelle, Van Beck, Margaret, Pereira, Ana C P, Kandaswamy, Radhika, McQuillin, Andrew, Collier, David A, Bass, Nicholas J, Young, Allan H, Lawrence, Jacob, Nicol Ferrier, I, Anjorin, Adebayo, Farmer, Anne, Curtis, David, Scolnick, Edward M, McGuffin, Peter, Daly, Mark J, Corvin, Aiden P, Holmans, Peter A, Blackwood, Douglas H, Gurling, Hugh M, Owen, Michael J, Purcell, Shaun M

“…To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong…”
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Prenatal Malnutrition and Adult Schizophrenia: Further Evidence From the 1959-1961 Chinese Famine by Xu, Ming-Qing, Sun, Wen-Sheng, Liu, Ben-Xiu, Feng, Guo-Yin, Yu, Lan, Yang, Lawrence, He, Guang, Sham, Pak, Susser, Ezra, St. Clair, David, He, Lin

“…Objective: Evidence from the 1944-1995 Dutch Hunger Winter and the 1959-1961 Chinese famines suggests that those conceived or in early gestation during…”
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Disruption of the neurexin 1 gene is associated with schizophrenia by Rujescu, Dan, Ingason, Andres, Cichon, Sven, Pietiläinen, Olli P.H., Barnes, Michael R., Toulopoulou, Timothea, Picchioni, Marco, Vassos, Evangelos, Ettinger, Ulrich, Bramon, Elvira, Murray, Robin, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, Steinberg, Stacy, Sigurdsson, Engilbert, Sigmundsson, Thordur, Petursson, Hannes, Gylfason, Arnaldur, Olason, Pall I., Hardarsson, Gudmundur, Jonsdottir, Gudrun A., Gustafsson, Omar, Fossdal, Ragnheidur, Giegling, Ina, Möller, Hans-Jürgen, Hartmann, Annette M., Hoffmann, Per, Crombie, Caroline, Fraser, Gillian, Walker, Nicholas, Lonnqvist, Jouko, Suvisaari, Jaana, Tuulio-Henriksson, Annamari, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A., Hansen, Thomas, Werge, Thomas, Kiemeney, Lambertus A., Franke, Barbara, Veltman, Joris, Buizer-Voskamp, Jacobine E., Sabatti, Chiara, Ophoff, Roel A., Rietschel, Marcella, Nöthen, Markus M., Stefansson, Kari, Peltonen, Leena, St Clair, David, Stefansson, Hreinn, Collier, David A.

“…Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined…”
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Copy Number Variation and Schizophrenia by St Clair, David

“…Over the last 12 months, a series of major articles have reported associations with schizophrenia of copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2,…”
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Common variants on 8p12 and 1q24.2 confer risk of schizophrenia by Shi, Yongyong, Li, Zhiqiang, Xu, Qi, Wang, Ti, Li, Tao, Shen, Jiawei, Zhang, Fengyu, Chen, Jianhua, Zhou, Guoquan, Ji, Weidong, Li, Baojie, Xu, Yifeng, Liu, Dengtang, Wang, Peng, Yang, Ping, Liu, Benxiu, Sun, Wensheng, Wan, Chunling, Qin, Shengying, He, Guang, Steinberg, Stacy, Cichon, Sven, Werge, Thomas, Sigurdsson, Engilbert, Tosato, Sarah, Palotie, Aarno, Nöthen, Markus M, Rietschel, Marcella, Ophoff, Roel A, Collier, David A, Rujescu, Dan, Clair, David St, Stefansson, Hreinn, Stefansson, Kari, Ji, Jue, Wang, Qingzhong, Li, Wenjin, Zheng, Linqing, Zhang, Hairong, Feng, Guoyin, He, Lin

“…Yongyong Shi, Lin He and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify two new…”
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Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging by Johnstone, Mandy, Vasistha, Navneet A., Barbu, Miruna C., Dando, Owen, Burr, Karen, Christopher, Edward, Glen, Sophie, Robert, Christelle, Fetit, Rana, Macleod, Kenneth G., Livesey, Matthew R., Clair, David St, Blackwood, Douglas H. R., Millar, Kirsty, Carragher, Neil O., Hardingham, Giles E., Wyllie, David J. A., Johnstone, Eve C., Whalley, Heather C., McIntosh, Andrew M., Lawrie, Stephen M., Chandran, Siddharthan

“…The molecular basis of how chromosome 16p13.11 microduplication leads to major psychiatric disorders is unknown. Here we have undertaken brain imaging of…”
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Penetrance for copy number variants associated with schizophrenia by Vassos, Evangelos, Collier, David A., Holden, Simon, Patch, Christine, Rujescu, Dan, St Clair, David, Lewis, Cathryn M.

“…The discovery of ‘high-risk’ de novo copy number variants (CNVs) associated with neuropsychiatric disorders such as schizophrenia offers the opportunity to…”
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Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961 by St Clair, David, Xu, Mingqing, Wang, Peng, Yu, Yaqin, Fang, Yourong, Zhang, Feng, Zheng, Xiaoying, Gu, Niufan, Feng, Guoyin, Sham, Pak, He, Lin

“…CONTEXT Schizophrenia is a common major mental disorder. Intrauterine nutritional deficiency may increase the risk of schizophrenia. The main evidence comes…”
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Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort by Athanasiu, Lavinia, Mattingsdal, Morten, Kähler, Anna K, Brown, Andrew, Gustafsson, Omar, Agartz, Ingrid, Giegling, Ina, Muglia, Pierandrea, Cichon, Sven, Rietschel, Marcella, Pietiläinen, Olli P.H, Peltonen, Leena, Bramon, Elvira, Collier, David, Clair, David St, Sigurdsson, Engilbert, Petursson, Hannes, Rujescu, Dan, Melle, Ingrid, Steen, Vidar M, Djurovic, Srdjan, Andreassen, Ole A

“…Abstract We have performed a genome-wide association study (GWAS) of schizophrenia in a Norwegian discovery sample of 201 cases and 305 controls (TOP study)…”
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The impact of divergence time on the nature of population structure: an example from Iceland by Price, Alkes L, Helgason, Agnar, Palsson, Snaebjorn, Stefansson, Hreinn, St Clair, David, Andreassen, Ole A, Reich, David, Kong, Augustine, Stefansson, Kari

“…The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and…”
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Structural and copy number variants in the human genome: implications for psychiatry by Clair, David St

“…Copy number variants are small chromosomal deletions and duplications. When they alter the dose of genes critical for normal brain development and adult brain…”
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