Search Results - "Clair, DKS"

Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle by Gilliam, Laura A. A, Ferreira, Leonardo F, Bruton, Joseph D, Moylan, Jennifer S, Westerblad, Hakan, St. Clair, Daret K, Reid, Michael B

“…1 Department of Physiology, ; 3 Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky; ; 2 Department of Physiology and Pharmacology,…”
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Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B by Barone, Eugenio, Cenini, Giovanna, Sultana, Rukhsana, Di Domenico, Fabio, Fiorini, Ada, Perluigi, Marzia, Noel, Teresa, Wang, Chi, Mancuso, Cesare, St Clair, Daret K, Butterfield, D Allan

“…The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of…”
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Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: Insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease by Robinson, Renã A. S., Joshi, Gururaj, Huang, Quanzhen, Sultana, Rukhsana, Baker, Austin S., Cai, Jian, Pierce, William, St. Clair, Daret K., Markesbery, William R., Butterfield, D. Allan

“…Proteomics analyses were performed on the brains of wild‐type (WT) controls and an Alzheimer's disease (AD) mouse model, APP/PS‐1 human double mutant knock‐in…”
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Exacerbation of Damage and Altered NF-kappa B Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury by Sullivan, Patrick G, Bruce-Keller, Annadora J, Rabchevsky, Alexander G, Christakos, Sylivia, Clair, Daret K. St, Mattson, Mark P, Scheff, Stephen W

“…Tumor necrosis factor α (TNFα) is widely expressed in both neurons and glia and has been shown to be upregulated after traumatic brain injury (TBI). TNFα…”
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Nuclear factor κB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2 by KININGHAM, Kelley K., XU, Yong, DAOSUKHO, Chotiros, POPOVA, Bilyana, CLAIR, Daret K. ST

“…Manganese superoxide dismutase (MnSOD) serves a protective role under conditions of oxidative stress mediated by such diverse agents as adriamycin, radiation,…”
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p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose by SINTHUPIBULYAKIT, Chompunoot, GRIMES, Kristopher R, DOMANN, Frederick E, YONG XU, FANG FANG, ITTARAT, Wanida, CLAIR, Daret K. St, CLAIR, William St

“…Metabolic change in cancer cells by preferential production of energy through glycolysis is a well-documented characteristic of cancer. However, whether…”
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IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression by KININGHAM, Kelley K., DAOSUKHO, Chotiros, ST. CLAIR, Daret K.

“…Cytokines, phorbol esters, radiation and chemotherapeutic drugs up-regulate the expression of MnSOD (manganese superoxide dismutase). Using the VA-13 cell…”
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ss-Amyloid Mediated Nitration of Manganese Superoxide Dismutase: Implication for Oxidative Stress in a APP super(NLh/NLh) X PS-1 super(P264L/P264L) Double Knock-In Mouse Model of Alzheimer's Disease by Anantharaman, M, Tangpong, J, Keller, J N, Murphy, M P, Markesbery, W R, Kiningham, K K, Clair, DKS

“…Alzheimer's disease is a multifactorial, progressive, age-related neurodegenerative disease. In familial Alzheimer's disease, Ass is excessively produced and…”
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HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity by Marecki, John C., Cota-Gomez, Adela, Vaitaitis, Gisela M., Honda, Jennifer R., Porntadavity, Sureerut, St. Clair, Daret K., Flores, Sonia C.

“…Regulation of the basal manganese superoxide dismutase ( SOD2) promoter depends on the transcriptional activity of the Sp family of transcription factors. Here…”
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Tamoxifen enhancement of TNF-α induced MnSOD expression: modulation of NF-κB dimerization by DAOSUKHO, Chotiros, KININGHAM, Kelley, KASARSKIS, Edward J, ITTARAT, Wanida, ST.CLAIR, Daret K

“…Manganese superoxide dismutase (MnSOD) has been shown to suppress the development of cancer. Tamoxifen (TAM), a nonsteroidal anti-estrogen that is widely used…”
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In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model by Oberley, Terry D, Xue, Yi, Zhao, Yunfeng, Kiningham, Kelley, Szweda, Luke I, St Clair, Daret K

“…To study early subcellular pathologic changes of tumorigenesis in mouse skin and possible modulation by overexpression of the mitochondrial antioxidant enzyme…”
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Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4 by Hirai, Futoshi, Motoori, Shigeatsu, Kakinuma, Shizuko, Tomita, Kazuo, Indo, Hiroko P, Kato, Hirotoshi, Yamaguchi, Taketo, Yen, Hsiu-Chuan, St Clair, Daret K, Nagano, Tetsuo, Ozawa, Toshihiko, Saisho, Hiromitsu, Majima, Hideyuki J

“…One of the major characteristics of tumor is the presence of a hypoxic cell population, which is caused by abnormal distribution of blood vessels. Manganese…”
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TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1 by Porntadavity, S, Xu, Y, Kiningham, K, Rangnekar, V M, Prachayasittikul, V, Prachayasitikul, V, St Clair, D K

“…Induction of manganese superoxide dismutase (MnSOD) in response to oxidative stress has been well established in animals, tissues, and cell culture. However,…”
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Transcriptional regulation of the 5' proximal promoter of the human manganese superoxide dismutase gene by Yeh, C C, Wan, X S, St Clair, D K

“…Manganese superoxide dismutase (MnSOD) is a primary antioxidant enzyme critical for maintaining normal cell function and for survival. Previously, we cloned…”
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