Search Results - "Claffey, K P"

Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs by Guttilla, I. K., Phoenix, K. N., Hong, X., Tirnauer, J. S., Claffey, K. P., White, B. A.

“…Mammosphere culture has been used widely for the enrichment of mammary epithelial stem cells and breast cancer stem cells (CSCs). Epithelial-to-mesenchymal…”
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Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation by MUNOZ-NAJAR, U. M, NEURATH, K. M, VUMBACA, F, CLAFFEY, K. P

“…The process of cancer cell invasion involves degradation of the extracellular matrix (ECM) by proteases, integrin adhesion and cell motility. The role of ECM…”
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Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis by DETMAR, M, BROWN, L. F, CLAFFEY, K. P, KIANG-TECK YEO, KOCHER, O, JACKMAN, R. W, BERSE, B, DVORAK, H. F

“…Psoriatic skin is characterized by microvascular hyperpermeability and angioproliferation, but the mechanisms responsible are unknown. We report here that the…”
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Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation by Zheng, J, Machida, K, Antoku, S, Ng, K Y, Claffey, K P, Mayer, B J

“…The v-Crk oncogene product consists of two protein interaction modules, a Src homology 2 (SH2) domain and a Src homology 3 (SH3) domain. Overexpression of…”
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Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice by Detmar, Michael, Brown, Lawrence F., Schön, Michael P., Elicker, Brett M., Velasco, Paula, Richard, Lisa, Fukumura, Dai, Monsky, Wayne, Claffey, Kevin P., Jain, Rakesh K.

“…Vascular endothelial growth factor (VEGF) has been implicated in the pathologic angiogenesis observed in psoriasis and other chronic inflammatory skin diseases…”
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Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways by CLAFFEY, K. P, WILKISON, W. O, SPIEGELMAN, B. M

“…Vascular endothelial growth factor (VEGF) is an angiogenic polypeptide that has been isolated from a variety of tumorigenic and nontransformed cell lines…”
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Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis by CLAFFEY, K. P, BROWN, L. F, DEL AGUILA, L. F, TOGNAZZI, K, KIANG-TECK YEO, MANSEAU, E. J, DVORAK, H. F

“…Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Hypoxia often…”
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Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis by Iruela-Arispe, L, Gordon, K, Hugo, C, Duijvestijn, AM, Claffey, KP, Reilly, M, Couser, WG, Alpers, CE, Johnson, RJ

“…In many glomerular diseases severe injury to the mesangium may occur, leading to matrix dissolution and damage to the glomerular capillaries. Although the…”
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Role of AP-1 and HIF-1 Transcription Factors in TGF-β Activation of VEGF Expression by Shih, Shu-Ching, Claffey, Kevin P.

“…Abstract Aberrant expression of vascular endothelial growth factor (VEGF) has been demonstrated to be associated with most human solid tumors. Here we report…”
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Hypoxia Regulates the Expression of Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) and its Receptors in Human Skin by Detmar, Michael, Brown, Lawrence F., Berse, Brygida, Jackman, Robert W., Elicker, Brett M., Dvorak, Harold F., Claffey, Kevin P.

“…Tissue hypoxia is a characteristic feature of malignant tumors and healing wounds, conditions that are associated with angiogenesis and with increased…”
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Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression : Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts by OKU, T, TJUVAJEV, J. G, MIYAGAWA, T, SASAJIMA, T, JOSHI, A, JOSHI, R, FINN, R, CLAFFEY, K. P, BLASBERG, R. G

“…Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, has been investigated as a potent mediator of brain tumor angiogenesis…”
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Expression of Vascular Endothelial Growth Factor Induces an Invasive Phenotype in Human Squamous Cell Carcinomas by Detmar, Michael, Velasco, Paula, Richard, Lisa, Claffey, Kevin P., Streit, Michael, Riccardi, Lucia, Skobe, Mihaela, Brown, Lawrence F.

“…Inhibition of the vascular endothelial growth factor (VEGF. receptor Flk-1 has been shown to prevent invasion of experimental squamous cell carcinomas (SCC)…”
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Gangliosides influence angiogenesis in an experimental mouse brain tumor by MANFREDI, M. G, SANGMOOK LIM, CLAFFEY, K. P, SEYFRIED, T. N

“…Gangliosides are sialated glycosphingolipids present on the plasma membranes of all vertebrate cells. Tumors shed gangliosides into the extracellular…”
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Hypoxia-mediated regulation of gene expression in mammalian cells by Shih, Shu-Ching, Claffey, Kevin P.

“…The molecular mechanism underlying oxygen sensing in mammalian cells has been extensively investigated in the areas of glucose transport, glycolysis,…”
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Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate by Lee, Menq-Jer, Thangada, Shobha, Claffey, Kevin P., Ancellin, Nicolas, Liu, Catherine H., Kluk, Michael, Volpi, Mario, Sha'afi, Ramadan I., Hla, Timothy

“…Vascular endothelial cells undergo morphogenesis into capillary networks in response to angiogenic factors. We show here that sphingosine-1-phosphate (SPP), a…”
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Differential protein expression profiles in estrogen receptor-positive and -negative breast cancer tissues using label-free quantitative proteomics by Rezaul, Karim, Thumar, Jay Kumar, Lundgren, Deborah H, Eng, Jimmy K, Claffey, Kevin P, Wilson, Lori, Han, David K

“…Identification of the proteins that are associated with estrogen receptor (ER) status is a first step towards better understanding of the hormone-dependent…”
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AMP-Activated Protein Kinase   2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling by Fox, M. M., Phoenix, K. N., Kopsiaftis, S. G., Claffey, K. P.

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Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression by Boesiger, J, Tsai, M, Maurer, M, Yamaguchi, M, Brown, L F, Claffey, K P, Dvorak, H F, Galli, S J

“…Vascular permeability factor/vascular endothelial cell growth factor (VPF/VEGF) can both potently enhance vascular permeability and induce proliferation of…”
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Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA by WILKISON, W. O, HYE YEONG MIN, CLAFFEY, K. P, SATTERBERG, B. L, SPIEGELMAN, B. M

“…The mouse adipsin gene encodes a serine protease with complement factor D activity that is expressed during adipocyte differentiation and is deficient in…”
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Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L by Shih, S C, Claffey, K P

“…A 126-base region of human vascular endothelial growth factor (VEGF) 3′-untranslated region, which we identified as the hypoxia stability region, forms seven…”
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