Search Results - "Claff, Tobias"

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication by Tsukamoto, Yuta, Hiono, Takahiro, Yamada, Shintaro, Matsuno, Keita, Faist, Aileen, Claff, Tobias, Hou, Jianyu, Namasivayam, Vigneshwaran, Vom Hemdt, Anja, Sugimoto, Satoko, Ng, Jin Ying, Christensen, Maria H, Tesfamariam, Yonas M, Wolter, Steven, Juranek, Stefan, Zillinger, Thomas, Bauer, Stefan, Hirokawa, Takatsugu, Schmidt, Florian I, Kochs, Georg, Shimojima, Masayuki, Huang, Yi-Shuian, Pichlmair, Andreas, Kümmerer, Beate M, Sakoda, Yoshihiro, Schlee, Martin, Brunotte, Linda, Müller, Christa E, Igarashi, Manabu, Kato, Hiroki

“…Orthomyxo- and bunyaviruses steal the 5' cap portion of host RNAs to prime their own transcription in a process called "cap snatching." We report that RNA…”
Get full text

Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain by Müller, Christa E., Claff, Tobias

Get full text

Irreversible Antagonists for the Adenosine A2B Receptor by Temirak, Ahmed, Schlegel, Jonathan G., Voss, Jan H., Vaaßen, Victoria J., Vielmuth, Christin, Claff, Tobias, Müller, Christa E.

“…Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed,…”
Get full text

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics by Voget, Rabea, Breidenbach, Julian, Claff, Tobias, Hingst, Alexandra, Sylvester, Katharina, Steinebach, Christian, Vu, Lan Phuong, Weiße, Renato H, Bartz, Ulrike, Sträter, Norbert, Müller, Christa E, Gütschow, Michael

“…A titrant for the SARS-CoV-2 main protease (M ) was developed that enables, for the first time, the exact determination of the concentration of the…”
Get full text

Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction by Claff, Tobias, Schlegel, Jonathan G., Voss, Jan H., Vaaßen, Victoria J., Weiße, Renato H., Cheng, Robert K. Y., Markovic-Mueller, Sandra, Bucher, Denis, Sträter, Norbert, Müller, Christa E.

“…The G s  protein-coupled adenosine A 2A receptor (A 2A AR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was…”
Get full text

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV‑2 Main Protease Inhibitors with High Target Specificity and Low Toxicity by Gao, Shenghua, Sylvester, Katharina, Song, Letian, Claff, Tobias, Jing, Lanlan, Woodson, Molly, Weiße, Renato H., Cheng, Yusen, Schäkel, Laura, Petry, Marvin, Gütschow, Michael, Schiedel, Anke C., Sträter, Norbert, Kang, Dongwei, Xu, Shujing, Toth, Karoly, Tavis, John, Tollefson, Ann E., Müller, Christa E., Liu, Xinyong, Zhan, Peng

“…The continuous spread of SARS-CoV-2 calls for more direct-acting antiviral agents to combat the highly infectious variants. The main protease (Mpro) is an…”
Get full text

Inside Cover: Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates (Angew. Chem. Int. Ed. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

Get full text

Inside Cover: Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates (Angew. Chem. Int. Ed. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…The adenosine A2A receptor (A2AAR), which is activated by the extracellular nucleoside adenosine, belongs to the family of G protein‐coupled receptors (GPCRs)…”
Get full text

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV‑2 Main Protease Inhibitors by Gao, Shenghua, Song, Letian, Claff, Tobias, Woodson, Molly, Sylvester, Katharina, Jing, Lanlan, Weiße, Renato H., Cheng, Yusen, Sträter, Norbert, Schäkel, Laura, Gütschow, Michael, Ye, Bing, Yang, Mianling, Zhang, Tao, Kang, Dongwei, Toth, Karoly, Tavis, John, Tollefson, Ann E., Müller, Christa E., Zhan, Peng, Liu, Xinyong

“…The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule antivirals are in demand. The main protease (Mpro) is an effective and…”
Get full text

Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity by Oneto, Angelo, Hamwi, Ghazl Al, Schäkel, Laura, Krüger, Nadine, Sylvester, Katharina, Petry, Marvin, Shamleh, Rasha Abu, Pillaiyar, Thanigaimalai, Claff, Tobias, Schiedel, Anke C, Sträter, Norbert, Gütschow, Michael, Müller, Christa E

“…SARS-CoV-2 infections pose a high risk for vulnerable patients. In this study, we designed benzoic acid halopyridyl esters bearing a variety of substituents as…”
Get full text

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV‑2 Main Protease Inhibitors as Antiviral Drugs by Breidenbach, Julian, Voget, Rabea, Si, Yaoyao, Hingst, Alexandra, Claff, Tobias, Sylvester, Katharina, Wolf, Valentina, Krasniqi, Vesa, Useini, Abibe, Sträter, Norbert, Ogura, Yukino, Kawaguchi, Atsushi, Müller, Christa E., Gütschow, Michael

“…Given the crucial role of the main protease (Mpro) in the replication cycle of SARS-CoV-2, this viral cysteine protease constitutes a high-profile drug target…”
Get full text

Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…The G protein‐coupled adenosine A2A receptor (A2AAR) is an important new (potential) drug target in immuno‐oncology, and for neurodegenerative diseases…”
Get full text

Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates by Claff, Tobias, Klapschinski, Tim A, Tiruttani Subhramanyam, Udaya K, Vaaßen, Victoria J, Schlegel, Jonathan G, Vielmuth, Christin, Voß, Jan H, Labahn, Jörg, Müller, Christa E

“…The G protein-coupled adenosine A receptor (A AR) is an important new (potential) drug target in immuno-oncology, and for neurodegenerative diseases…”
Get full text

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists by Claff, Tobias, Yu, Jing, Blais, Véronique, Patel, Nilkanth, Martin, Charlotte, Wu, Lijie, Han, Gye Won, Holleran, Brian J, Van der Poorten, Olivier, White, Kate L, Hanson, Michael A, Sarret, Philippe, Gendron, Louis, Cherezov, Vadim, Katritch, Vsevolod, Ballet, Steven, Liu, Zhi-Jie, Müller, Christa E, Stevens, Raymond C

“…Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ancillary anxiolytic and…”
Get full text

Irreversible Antagonists for the Adenosine A 2B Receptor by Temirak, Ahmed, Schlegel, Jonathan G, Voss, Jan H, Vaaßen, Victoria J, Vielmuth, Christin, Claff, Tobias, Müller, Christa E

“…Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed,…”
Get full text

Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction by Claff, Tobias, Schlegel, Jonathan G, Voss, Jan H, Vaaßen, Victoria J, Weiße, Renato H, Cheng, Robert K Y, Markovic-Mueller, Sandra, Bucher, Denis, Sträter, Norbert, Müller, Christa E

“…The G  protein-coupled adenosine A receptor (A AR) represents an emerging drug target for cancer immunotherapy. The clinical candidate Etrumadenant was…”
Get full text

Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A 2A Receptor by Claff, Tobias, Mahardhika, Andhika B, Vaaßen, Victoria J, Schlegel, Jonathan G, Vielmuth, Christin, Weiße, Renato H, Sträter, Norbert, Müller, Christa E

“…The adenosine A receptor (A AR) belongs to the rhodopsin-like G protein-coupled receptor (GPCR) family, which constitutes the largest class of GPCRs. Partial…”
Get full text

Eine einzige stabilisierende Punktmutation ermöglicht hochaufgelöste Co‐Kristallstrukturen des Adenosin‐A2A‐Rezeptors mit Preladenant‐Konjugaten by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

“…Der G‐Protein‐gekoppelte Adenosin‐A2A‐Rezeptor (A2AAR) stellt eine wichtige neue (potentielle) Arzneistoff‐Zielstruktur für die Immunonkologie und für…”
Get full text

Innentitelbild: Eine einzige stabilisierende Punktmutation ermöglicht hochaufgelöste Co‐Kristallstrukturen des Adenosin‐A 2A ‐Rezeptors mit Preladenant‐Konjugaten (Angew. Chem. 22/2022) by Claff, Tobias, Klapschinski, Tim A., Tiruttani Subhramanyam, Udaya K., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Voß, Jan H., Labahn, Jörg, Müller, Christa E.

Get full text

Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor by Claff, Tobias, Mahardhika, Andhika B., Vaaßen, Victoria J., Schlegel, Jonathan G., Vielmuth, Christin, Weiße, Renato H., Sträter, Norbert, Müller, Christa E.

“…The adenosine A2A receptor (A2AAR) belongs to the rhodopsin-like G protein-coupled receptor (GPCR) family, which constitutes the largest class of GPCRs…”
Get full text