Search Results - "Claessen, H."

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins by Mueller, Britta, Klemm, Elizabeth J, Spooner, Eric, Claessen, Jasper H, Ploegh, Hidde L

“…Membrane and secretory proteins that fail to pass quality control in the endoplasmic reticulum are discharged into the cytosol and degraded by the proteasome…”
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Large-scale assessment of human navigation ability across the lifespan by van der Ham, Ineke J. M., Claessen, Michiel H. G., Evers, Andrea W. M., van der Kuil, Milan N. A.

“…Navigation ability is particularly sensitive to aging. Evidence of aging patterns is largely restricted to comparing young adults and elderly and limited in…”
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The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice by Boots, Agnes W, Veith, Carmen, Albrecht, Catrin, Bartholome, Roger, Drittij, Marie-José, Claessen, Sandra M H, Bast, Aalt, Rosenbruch, Martin, Jonkers, Leonie, van Schooten, Frederik-Jan, Schins, Roel P F

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, lethal disease of which the etiology is still not fully understood. Current treatment comprises two…”
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A clinical guide to assessment of navigation impairment: Standardized subjective and objective instruments and normative data by van der Ham, Ineke J.M., Claessen, Michiel H.G.

“…Problems with finding one's way around are frequently reported by neurological patients. However, no dedicated standardized tools exist to assess whether such…”
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Enzymatic blockade of the ubiquitin-proteasome pathway by Ernst, Robert, Claessen, Jasper H L, Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G, Kirak, Oktay, Schlieker, Christian D, Weihofen, Wilhelm A, Ploegh, Hidde L

“…Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating…”
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The chaperone BAG6 captures dislocated glycoproteins in the cytosol by Claessen, Jasper H L, Sanyal, Sumana, Ploegh, Hidde L

“…Secretory and membrane (glyco)proteins are subject to quality control in the endoplasmic reticulum (ER) to ensure that only functional proteins reach their…”
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BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum by Claessen, Jasper H L, Ploegh, Hidde L

“…Secretory and membrane proteins that fail to acquire their native conformation within the lumen of the Endoplasmic Reticulum (ER) are usually targeted for…”
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Limited additive value of the Ki‐67 proliferative index on patient survival in World Health Organization‐classified pulmonary carcinoids by Swarts, Dorian R A, Rudelius, Martina, Claessen, Sandra M H, Cleutjens, Jack P, Seidl, Stefan, Volante, Marco, Ramaekers, Frans C S, Speel, Ernst J M

“…Aims Currently pulmonary carcinoids are separated into typical and atypical based on mitotic count and presence of necrosis, according to the World Health…”
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Overweight, obesity and risk of work disability: a cohort study of construction workers in Germany by Claessen, H, Arndt, V, Drath, C, Brenner, H

“…Objectives:Although obesity and permanent work disability impose a great burden on the individual and are very costly for society, data on the impact of being…”
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Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression in Chlamydia trachomatis Infection by Claessen, Jasper H. L., Witte, Martin D., Yoder, Nicholas C., Zhu, Angela Y., Spooner, Eric, Ploegh, Hidde L.

“…Protein ubiquitylation controls many cellular pathways, and timely removal of ubiquitin by deubiquitylating enzymes (DUBs) is essential to govern these…”
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Time-Response Evaluation by Transcriptomics of Methylmercury Effects on Neural Differentiation of Murine Embryonic Stem Cells by Theunissen, Peter T., Pennings, Jeroen L. A., Robinson, Joshua F., Claessen, Sandra M. H., Kleinjans, Jos C. S., Piersma, Aldert H.

“…Current globally harmonized Organisation for Economic Co-operation and Development (OECD) animal test guidelines for developmental toxicity require high…”
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Flexible Linked Axes for Multivariate Data Visualization by Claessen, J. H. T., van Wijk, J. J.

“…Multivariate data visualization is a classic topic, for which many solutions have been proposed, each with its own strengths and weaknesses. In standard…”
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Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn) by Theunissen, Peter T., Robinson, Joshua F., Pennings, Jeroen L. A., de Jong, Esther, Claessen, Sandra M. H., Kleinjans, Jos C. S., Piersma, Aldert H.

“…Alternative developmental toxicity assays are urgently needed to reduce animal use in regulatory developmental toxicology. We previously designed an in vitro…”
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Dissociating Spatial and Spatiotemporal Aspects of Navigation Ability in Chronic Stroke Patients by Claessen, Michiel H. G, Visser-Meily, Johanna M. A, Jagersma, Elbrich, Braspenning, Merel E, van der Ham, Ineke J. M

“…Objective: The notion of distinguishable processing mechanisms for spatial and spatiotemporal information has largely been neglected in the context of…”
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Dystrophin in the Neonatal and Adult Rat Intestine by Lionarons, Judith M., Hoogland, Govert, Slegers, Rutger J., Steinbusch, Hellen, Claessen, Sandra M. H., Vles, Johan S. H.

“…Background: Gastrointestinal (GI) complaints are frequently noted in aging dystrophinopathy patients, yet their underlying molecular mechanisms are largely…”
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Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis by van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.

“…Arsenic is an established human carcinogen, but the mechanisms through which it contributes to for instance lung cancer development are still unclear. As…”
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A Direct Comparison of Real-World and Virtual Navigation Performance in Chronic Stroke Patients by Claessen, Michiel H G, Visser-Meily, Johanna M A, de Rooij, Nicolien K, Postma, Albert, van der Ham, Ineke J M

“…An increasing number of studies have presented evidence that various patient groups with acquired brain injury suffer from navigation problems in daily life…”
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Navigation strategy training using virtual reality in six chronic stroke patients: A novel and explorative approach to the rehabilitation of navigation impairment by Claessen, Michiel H. G., van der Ham, Ineke J. M., Jagersma, Elbrich, Visser-Meily, Johanna M. A.

“…Recent studies have shown that navigation impairment is a common complaint after brain injury. Effective training programmes aiming to improve navigation…”
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Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis by Mooren, Jeroen J., Kremer, Bernd, Claessen, Sandra M.H., Voogd, Adri C., Bot, Fredrik J., Peter Klussmann, J., Huebbers, Christian U., Hopman, Anton H.N., Ramaekers, Frans C.S., Speel, Ernst‐Jan M.

“…Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems…”
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Computerization of the Standard Corsi Block-Tapping Task Affects Its Underlying Cognitive Concepts: A Pilot Study by Claessen, Michiel H. G., van der Ham, Ineke J. M., van Zandvoort, Martine J. E.

“…The tablet computer initiates an important step toward computerized administration of neuropsychological tests. Because of its lack of standardization, the…”
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