Search Results - "Claes Wahlestedt"

Regulatory roles of natural antisense transcripts by Wahlestedt, Claes, Faghihi, Mohammad Ali

“…Natural antisense transcripts are frequently functional and are involved in regulating gene expression. The authors summarize the proposed actions of antisense…”
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The Landscape of long noncoding RNA classification by St. Laurent, Georges, Wahlestedt, Claes, Kapranov, Philipp

“…Highlights • ncRNAs constitute the majority of transcriptional output of the human genome. • Lack of functional knowledge of most of ncRNAs has led to…”
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Non-coding RNAs as direct and indirect modulators of epigenetic regulation by Peschansky, Veronica J, Wahlestedt, Claes

“…Epigenetic regulation of gene expression is an increasingly well-understood concept that explains much of the contribution of an organism's environment and…”
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Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls by Cao, Huifen, Wahlestedt, Claes, Kapranov, Philipp

“…The past decade has seen an explosion of interest in long noncoding RNAs (lncRNAs). However, despite the massive volume of scientific data implicating these…”
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Emerging treatment strategies for glioblastoma multiforme by Carlsson, Steven K, Brothers, Shaun P, Wahlestedt, Claes

“…Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐year mortality. GBM has a paltry median survival of 12.6 months…”
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Personalized medicine in psychiatry: problems and promises by Ozomaro, Uzoezi, Wahlestedt, Claes, Nemeroff, Charles B

“…The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease…”
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Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme by Tan, Sze Kiat, Pastori, Chiara, Penas, Clara, Komotar, Ricardo J, Ivan, Michael E, Wahlestedt, Claes, Ayad, Nagi G

“…Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and…”
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Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS by Wahlestedt, Claes, Khorkova, Olga

“…Besides his vast contribution to the opioid receptor studies, Dr. G. W. Pasternak was among the early pioneers in the antisense oligonucleotide (ASO) field at…”
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Involvement of long noncoding RNAs in diseases affecting the central nervous system by Pastori, Chiara, Wahlestedt, Claes

“…DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly…”
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Therapeutic potential of neuropeptide Y (NPY) receptor ligands by Brothers, Shaun P., Wahlestedt, Claes

“…Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. Since its discovery, NPY has been…”
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shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics by Khomtchouk, Bohdan B, Hennessy, James R, Wahlestedt, Claes

“…Transcriptomics, metabolomics, metagenomics, and other various next-generation sequencing (-omics) fields are known for their production of large datasets,…”
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Molecular mechanisms of psychiatric diseases by Blokhin, Ilya O., Khorkova, Olga, Saveanu, Radu V., Wahlestedt, Claes

“…For most psychiatric diseases, pathogenetic concepts as well as paradigms underlying neuropsychopharmacologic approaches currently revolve around…”
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Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts by Magistri, Marco, Faghihi, Mohammad Ali, St Laurent, Georges, Wahlestedt, Claes

“…In the decade following the publication of the Human Genome, noncoding RNAs (ncRNAs) have reshaped our understanding of the broad landscape of genome…”
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Altering the course of schizophrenia: progress and perspectives by Millan, Mark J., Andrieux, Annie, Bartzokis, George, Cadenhead, Kristin, Dazzan, Paola, Fusar-Poli, Paolo, Gallinat, Jürgen, Giedd, Jay, Grayson, Dennis R., Heinrichs, Markus, Kahn, René, Krebs, Marie-Odile, Leboyer, Marion, Lewis, David, Marin, Oscar, Marin, Philippe, Meyer-Lindenberg, Andreas, McGorry, Patrick, McGuire, Philip, Owen, Michael J., Patterson, Paul, Sawa, Akira, Spedding, Michael, Uhlhaas, Peter, Vaccarino, Flora, Wahlestedt, Claes, Weinberger, Daniel

“…Key Points Schizophrenia is a debilitating and chronic disorder that is accompanied by psychosis and a broad spectrum of behavioural, cognitive and social…”
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Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation by Modarresi, Farzaneh, Faghihi, Mohammad Ali, Lopez-Toledano, Miguel A, Fatemi, Roya Pedram, Magistri, Marco, Brothers, Shaun P, van der Brug, Marcel P, Wahlestedt, Claes

“…Methods for specific gene silencing have advanced as far as clinical trials, but a similar set of tools does not exist for increasing gene expression…”
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Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation by Pastori, Chiara, Philipp Kapranov, Clara Penas, Veronica Peschansky, Claude-Henry Volmar, Jann N. Sarkaria, Amade Bregy, Ricardo Komotar, Georges St. Laurent, Nagi G. Ayad, Claes Wahlestedt

“…Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule…”
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Vitamin C Sensitizes Melanoma to BET Inhibitors by Mustafi, Sushmita, Camarena, Vladimir, Volmar, Claude-Henry, Huff, Tyler C, Sant, David W, Brothers, Shaun P, Liu, Zhao-Jun, Wahlestedt, Claes, Wang, Gaofeng

“…Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in…”
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Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis by Argemi, Josepmaria, Latasa, Maria U., Atkinson, Stephen R., Blokhin, Ilya O., Massey, Veronica, Gue, Joel P., Cabezas, Joaquin, Lozano, Juan J., Van Booven, Derek, Bell, Aaron, Cao, Sheng, Vernetti, Lawrence A., Arab, Juan P., Ventura-Cots, Meritxell, Edmunds, Lia R., Fondevila, Constantino, Stärkel, Peter, Dubuquoy, Laurent, Louvet, Alexandre, Odena, Gemma, Gomez, Juan L., Aragon, Tomas, Altamirano, Jose, Caballeria, Juan, Jurczak, Michael J., Taylor, D. Lansing, Berasain, Carmen, Wahlestedt, Claes, Monga, Satdarshan P., Morgan, Marsha Y., Sancho-Bru, Pau, Mathurin, Philippe, Furuya, Shinji, Lackner, Carolin, Rusyn, Ivan, Shah, Vijay H., Thursz, Mark R., Mann, Jelena, Avila, Matias A., Bataller, Ramon

“…Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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Antisense RNA Controls LRP1 Sense Transcript Expression through Interaction with a Chromatin-Associated Protein, HMGB2 by Yamanaka, Yasunari, Faghihi, Mohammad Ali, Magistri, Marco, Alvarez-Garcia, Oscar, Lotz, Martin, Wahlestedt, Claes

“…Long non-coding RNAs (lncRNAs), including natural antisense transcripts (NATs), are expressed more extensively than previously anticipated and have widespread…”
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