Search Results - "Clément, Philippe"

Therapeutic Value of an Integrin Antagonist in Prostate Cancer by Philippe, Clément-Lacroix

“…In recent decades we have seen an exponential interest in the implications of integrin receptors in cancer biology and especially in prostate tumour…”
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Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass by Morvan, Frederic, Boulukos, Kim, Clément‐Lacroix, Philippe, Roman, Sergio Roman, Suc‐Royer, Isabelle, Vayssière, Béatrice, Ammann, Patrick, Martin, Patrick, Pinho, Sonia, Pognonec, Philippe, Mollat, Patrick, Niehrs, Christof, Baron, Roland, Rawadi, Georges

“…Wnt/β‐catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast…”
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ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier by Drolez, Aurore, Vandenhaute, Elodie, Delannoy, Clément Philippe, Dewald, Justine Hélène, Gosselet, Fabien, Cecchelli, Romeo, Julien, Sylvain, Dehouck, Marie-Pierre, Delannoy, Philippe, Mysiorek, Caroline

“…The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes…”
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Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis by Mammoliti, Oscar, Palisse, Adeline, Joannesse, Caroline, El Bkassiny, Sandy, Allart, Brigitte, Jaunet, Alex, Menet, Christel, Coornaert, Beatrice, Sonck, Kathleen, Duys, Inge, Clément-Lacroix, Philippe, Oste, Line, Borgonovi, Monica, Wakselman, Emanuelle, Christophe, Thierry, Houvenaghel, Nicolas, Jans, Mia, Heckmann, Bertrand, Sanière, Laurent, Brys, Reginald

“…Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary…”
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Lrp5-Independent Activation of Wnt Signaling by Lithium Chloride Increases Bone Formation and Bone Mass in Mice by Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Warman, Matthew L., Baron, Roland, Georges Rawadi, Prockop, Darwin J.

“…One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3/3 and the consequent activation of canonical Wnt…”
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Discovery of Diarylhydantoins as New Selective Androgen Receptor Modulators by Nique, François, Hebbe, Séverine, Peixoto, Christophe, Annoot, Denis, Lefrançois, Jean-Michel, Duval, Eric, Michoux, Laurence, Triballeau, Nicolas, Lemoullec, Jean-Michel, Mollat, Patrick, Thauvin, Maxime, Prangé, Thierry, Minet, Dominique, Clément-Lacroix, Philippe, Robin-Jagerschmidt, Catherine, Fleury, Damien, Guédin, Denis, Deprez, Pierre

“…A novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens. Several…”
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The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis by Puengel, Tobias, De Vos, Steve, Hundertmark, Jana, Kohlhepp, Marlene, Guldiken, Nurdan, Pujuguet, Philippe, Auberval, Marielle, Marsais, Florence, Shoji, Kenji F, Saniere, Laurent, Trautwein, Christian, Luedde, Tom, Strnad, Pavel, Brys, Reginald, Clément-Lacroix, Philippe, Tacke, Frank

“…Medium-chain fatty acids (MCFAs) have been associated with anti-steatotic effects in hepatocytes. Expression of the MCFA receptor GPR84 (G protein-coupled…”
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Tumor αvβ3 integrin is a therapeutic target for breast cancer bone metastases by YINGSHE ZHAO, BACHELIER, Richard, TREILLEUX, Isabelle, PUJUGUET, Philippe, PEYRUCHAUD, Olivier, BARON, Roland, CLEMENT-LACROIX, Philippe, CLEZARDIN, Philippe

“…In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone…”
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Comparison of LigaSure vessel sealing system, harmonic scalpel, and conventional hemostasis in total thyroidectomy by Pons, Yoann, Gauthier, Jérome, Ukkola-Pons, Elsa, Clément, Philippe, Roguet, Eric, Poncet, Jean-Luc, Conessa, Claude

“…The aim of the study was to compare the efficiency, safety, and cost of the different methods of hemostasis (conventional hemostasis versus LigaSure vessel…”
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Glucose Regulates m6A Methylation of RNA in Pancreatic Islets by Bornaque, Florine, Delannoy, Clément Philippe, Courty, Emilie, Rabhi, Nabil, Carney, Charlène, Rolland, Laure, Moreno, Maeva, Gromada, Xavier, Bourouh, Cyril, Petit, Pauline, Durand, Emmanuelle, Pattou, François, Kerr-Conte, Julie, Froguel, Philippe, Bonnefond, Amélie, Oger, Frédérik, Annicotte, Jean-Sébastien

“…Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin action and secretion. Although the heritability of type 2 diabetes…”
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High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry by Delannoy, Clément Philippe, Heuson, Egon, Herledan, Adrien, Oger, Frederik, Thiroux, Bryan, Chevalier, Mickaël, Gromada, Xavier, Rolland, Laure, Froguel, Philippe, Deprez, Benoit, Paul, Sébastien, Annicotte, Jean-Sébastien

“…Type 2 diabetes (T2D) is a metabolic disorder characterized by loss of pancreatic β-cell function, decreased insulin secretion and increased insulin…”
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Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density by Ellwanger, Kristina, Saito, Hiroaki, Clément-Lacroix, Philippe, Maltry, Nicole, Niedermeyer, Joachim, Lee, Woon Kyu, Baron, Roland, Rawadi, Georges, Westphal, Heiner, Niehrs, Christof

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Real time TEM observation of alumina ceramic nano-particles during compression by Calvié, Emilie, Joly-Pottuz, Lucile, Esnouf, Claude, Clément, Philippe, Garnier, Vincent, Chevalier, Jérôme, Jorand, Yves, Malchère, Annie, Epicier, Thierry, Masenelli-Varlot, Karine

“…The behavior of alumina nano-particles taken from a commercial powder is investigated during in situ compression experiments in a transmission electron…”
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A simple approach to the Cauchy problem for complex Ginzburg–Landau equations by compactness methods by Clément, Philippe, Okazawa, Noboru, Sobajima, Motohiro, Yokota, Tomomi

“…This paper is concerned with the Cauchy problem (CGL) in L2(RN) for complex Ginzburg–Landau equations with Laplacian Δ and nonlinear term |u|q−2u multiplied by…”
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Targeting of alpha-v integrins reduces malignancy of bladder carcinoma by van der Horst, Geertje, Bos, Lieke, van der Mark, Maaike, Cheung, Henry, Heckmann, Bertrand, Clément-Lacroix, Philippe, Lorenzon, Giocondo, Pelger, Rob C M, Bevers, Rob F M, van der Pluijm, Gabri

“…Low survival rates of metastatic cancers emphasize the need for a drug that can prevent and/or treat metastatic cancer. αv integrins are involved in essential…”
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Early Tympanoplasty Using a Synthetic Biomembrane for Military-Related Blast Induced Large Tympanic Membrane Perforation by Ballivet de Régloix, Stanislas, Crambert, Anna, Salf, Eric, Maurin, Olga, Pons, Yoann, Clément, Philippe

“…Blast injuries in modern warfare are common, and tympanic perforation is often found. Spontaneous closures of large perforations that encompass greater than…”
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A Trotter product formula for gradient flows in metric spaces by Clément, Philippe, Maas, Jan

“…We prove a Trotter product formula for gradient flows in metric spaces. This result is applied to establish convergence in the L 2 -Wasserstein metric of the…”
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Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization by Blanqué, Roland, Lepescheux, Liên, Auberval, Marielle, Minet, Dominique, Merciris, Didier, Cottereaux, Céline, Clément-Lacroix, Philippe, Delerive, Philippe, Namour, Florence

“…Muscle wasting is a hallmark of many chronic conditions but also of aging and results in a progressive functional decline leading ultimately to disability…”
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Schauder estimates for a degenerate second order elliptic operator on a cube by Cerrai, Sandra, Clément, Philippe

“…In the present article we are concerned with a class of degenerate second order differential operators L A , b defined on the cube [ 0 , 1 ] d , with d ⩾ 1 …”
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No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions by Wellendorph, Petrine, Johansen, Lars Dan, Jensen, Anders A, Casanova, Emilio, Gassmann, Martin, Deprez, Pierre, Clément-Lacroix, Philippe, Bettler, Bernhard, Bräuner-Osborne, Hans

“…GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of l-α-amino acids, a signaling augmented by the divalent cations Ca2+ and Mg2+…”
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