Search Results - "Ciznadija, D."

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors by Izumchenko, E., Paz, K., Ciznadija, D., Sloma, I., Katz, A., Vasquez-Dunddel, D., Ben-Zvi, I., Stebbing, J., McGuire, W., Harris, W., Maki, R., Gaya, A., Bedi, A., Zacharoulis, S., Ravi, R., Wexler, L.H., Hoque, M.O., Rodriguez-Galindo, C., Pass, H., Peled, N., Davies, A., Morris, R., Hidalgo, M., Sidransky, D.

“…While patient-derived xenografts (PDXs) offer a powerful modality for translational cancer research, a precise evaluation of how accurately patient responses…”
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TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.) by Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N P, Brennan, C, Holland, E C, Koff, A

“…The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer…”
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Patient-derived xenograft (PDX) models of BRCA-deficient and BRCA-like ovarian tumors reflect clinical responses to PARP inhibition by Davies, A, Hou, J, Shih, L.M, Wright, J.D, Ciznadija, D, Katz, A, Sidransky, D

“…Background: PARP inhibition in BRCA-deficientlBRCA-like ovarian tumors can lead to synthetic lethality. The FDA has approved a PARP inhibitor to treat…”
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Genomic characterization of immune targets in patient-derived xenograft models for translational assessment of immunotherapy by Cerna, D, Ciznadija, D, Ben zvi, I, Sloma, I, Sidransky, D, Davies, A, Goodwin, N

“…Background: Although oncology therapies reactivating the immune response by targeting checkpoints such as PD1 and PD-Li are now FDA approved, development of…”
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Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling by Ciznadija, D, Tothill, R, Waterman, M L, Zhao, L, Huynh, D, Yu, R M, Ernst, M, Ishii, S, Mantamadiotis, T, Gonda, T J, Ramsay, R G, Malaterre, J

“…Aberrant Wnt signaling mediated by mutations affecting APC (adenomatous polyposis coli) or β -catenin initiates the majority of human colorectal cancers (CRC)…”
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195 A humanized mouse model for preclinical testing of molecules targeting immune checkpoints by Baia, G, Vasquez, D, Ciznadija, D, Sidransky, D, Katz, A, Paz, K

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Patient-derived xenografts effectively capture patient clinical responses to oncology therapy by Davies, A, Stebbing, J, Zacharoulis, S, Gaya, A, McGuire, W, Harris, W, Maki, R, Hidalgo, M, Vasquez-Dunddel, D, Ciznadija, D, Katz, A, Sidransky, D

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Transcriptional regulation of cyclo-oxygenase expression: three pillars of control by Ramsay, R G, Ciznadija, D, Vanevski, M, Mantamadiotis, T

“…Blocking cyclo-oxygenase (COX) isoform activities with non-steroidal anti-inflammatory drugs (NSAIDS) is widely employed in the treatment of arthritis. These…”
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Mouse clinical trials of pancreatic cancer: Integration of PDX models with genomics to improve patient outcomes to chemotherapeutics by Davies, A., Hidalgo, M., Stebbing, J., Ciznadija, D., Katz, A., Sidransky, D.

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335 - Patient-derived xenograft (PDX) models of BRCA-deficient and BRCA-like ovarian tumors reflect clinical responses to PARP inhibition by Davies, A., Hou, J., Shih, L.M., Wright, J.D., Ciznadija, D., Katz, A., Sidransky, D.

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334 - Genomic characterization of immune targets in patient-derived xenograft models for translational assessment of immunotherapy by Cerna, D., Ciznadija, D., Ben zvi, I., Sloma, I., Sidransky, D., Davies, A., Goodwin, N.

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877 - Patient-derived xenografts effectively capture patient clinical responses to oncology therapy by Davies, A., Stebbing, J., Zacharoulis, S., Gaya, A., McGuire, W., Harris, W., Maki, R., Hidalgo, M., Vasquez-Dunddel, D., Ciznadija, D., Katz, A., Sidransky, D.

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Patient-Derived Xenografts Accurately Capture Clinical Responses to Treatment by Stebbing, J., Zacharoulis, S., Gaya, A., McGuire, W., Harris, W., Maki, R.G., Hidalgo, M., Davies, A., Vasquez-Dunddel, D., Ciznadija, D., Katz, A., Sidransky, D., Paz, K.

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1573PDPATIENT-DERIVED XENOGRAFTS ACCURATELY CAPTURE CLINICAL RESPONSES TO TREATMENT by Stebbing, J., Zacharoulis, S., Gaya, A., McGuire, W., Harris, W., Maki, R.G., Hidalgo, M., Davies, A., Vasquez-Dunddel, D., Ciznadija, D., Katz, A., Sidransky, D., Paz, K.

“…Abstract Aim: The inability to distinguish patient populations that are most likely to respond to different treatments is a continuing challenge for medical…”
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TRIM3, a tumor suppressor linked to regulation of [p21.sup.Waf1/Cip1] by Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A.M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N.P, Brennan, C, Holland, E.C, Koff, A

“…The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer…”
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TRIM3, a tumor suppressor linked to regulation of p21 super(Waf1/Cip1) by Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N P, Brennan, C, Holland, E C, Koff, A

“…The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer…”
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TRIM3, a tumor suppressor linked to regulation of p21Waf1/Cip1 by Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N P, Brennan, C, Holland, E C, Koff, A

“…The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer…”
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Expression of stress response protein glucose regulated protein-78 mediated by c-Myb by Ramsay, Robert G., Ciznadija, Daniel, Mantamadiotis, Theo, Anderson, Robin, Pearson, Richard

“…Glucose regulated protein-78, GRP78 has been implicated in the protection of tumor cells from cytotoxic damage and apoptosis. When protein profiles of colon…”
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Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS by Ramsay, Robert G, Ciznadija, Daniel, Sicurella, Catherine, Reyes, Nancy, Mitchelhill, Ken, Darcy, Phillip K, D'Abaco, Giovanna, Mantamadiotis, Theo

“…Blocked differentiation is a hallmark of cancer cells and the restoration of differentiation programs in vivo is an actively pursued clinical aim…”
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