Search Results - "Civin, Curt I."

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile by Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz

“…Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on…”
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CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control by Georgantas, Robert W. III, Hildreth, Richard, Morisot, Sebastien, Alder, Jonathan, Liu, Chang-gong, Heimfeld, Shelly, Calin, George A, Croce, Carlo M, Civin, Curt I

“…MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of small noncoding RNAs that bind to the 3' untranslated region of mRNAs…”
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Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome by Huang, Cheng Ran Lisa, Schneider, Anna M., Lu, Yunqi, Niranjan, Tejasvi, Shen, Peilin, Robinson, Matoya A., Steranka, Jared P., Valle, David, Civin, Curt I., Wang, Tao, Wheelan, Sarah J., Ji, Hongkai, Boeke, Jef D., Burns, Kathleen H.

“…Characterizing structural variants in the human genome is of great importance, but a genome wide analysis to detect interspersed repeats has not been done…”
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MIR144 and MIR451 regulate human erythropoiesis via RAB14 by Kim, MinJung, Tan, Yee Sun, Cheng, Wen‐Chih, Kingsbury, Tami J., Heimfeld, Shelly, Civin, Curt I.

“…Summary Expression levels of MIR144 and MIR451 increase during erythropoiesis, a pattern that is conserved from zebrafish to humans. As these two miRs are…”
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Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development by Zambidis, Elias T., Peault, Bruno, Park, Tea Soon, Bunz, Fred, Civin, Curt I.

“…We elucidate the cellular and molecular kinetics of the stepwise differentiation of human embryonic stem cells (hESC338) to primitive and definitive…”
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Characterization of clonogenic multiple myeloma cells by Matsui, William, Huff, Carol Ann, Wang, Qiuju, Malehorn, Matthew T., Barber, James, Tanhehco, Yvette, Smith, B. Douglas, Civin, Curt I., Jones, Richard J.

“…The identity of the cells responsible for the initiation and maintenance of multiple myeloma (MM) remains unclear largely because of the difficulty growing MM…”
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Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia by Tan, Yee Sun, Kim, MinJung, Kingsbury, Tami J, Civin, Curt I, Cheng, Wen-Chih

“…MicroRNAs (miRs) regulate essentially all cellular processes, but few miRs are known to inhibit growth of precursor-B acute lymphoblastic leukemias (B-ALLs)…”
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Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo by Alder, Jonathan K, Georgantas, Robert W., III, Hildreth, Richard L, Kaplan, Ian M, Morisot, Sebastien, Yu, Xiaobing, McDevitt, Michael, Civin, Curt I

“…Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood…”
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Automated leukocyte processing by microfluidic deterministic lateral displacement by Civin, Curt I., Ward, Tony, Skelley, Alison M., Gandhi, Khushroo, Peilun Lee, Zendra, Dosier, Christopher R., D'Silva, Joseph L., Chen, Yu, Kim, MinJung, Moynihan, James, Chen, Xiaochun, Aurich, Lee, Gulnik, Sergei, Brittain, George C., Recktenwald, Diether J., Austin, Robert H., Sturm, James C.

“…We previously developed a Deterministic Lateral Displacement (DLD) microfluidic method in silicon to separate cells of various sizes from blood (Davis et al.,…”
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A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology by Kagan, Amanda B, Moses, Blake S, Mott, Bryan T, Rai, Ganesha, Anders, Nicole M, Rudek, Michelle A, Civin, Curt I

“…Acute myeloid leukemia (AML) remains a devastating disease, with low cure rates despite intensive standard chemotherapy regimens. In the past decade, targeted…”
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MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ by Scheibner, Kara A, Teaboldt, Brianne, Hauer, Mary Claire, Chen, Xiaochun, Cherukuri, Srujana, Guo, Yin, Kelley, Shannon M, Liu, Zhenqiu, Baer, Maria R, Heimfeld, Shelly, Civin, Curt I

“…MicroRNAs (miRs) play major roles in normal hematopoietic differentiation and hematopoietic malignancies. In this work, we report that miR-27a, and its…”
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HES1 Inhibits Cycling of Hematopoietic Progenitor Cells via DNA Binding by Yu, Xiaobing, Alder, Jonathan K., Chun, Jong Ho, Friedman, Alan D., Heimfeld, Shelly, Cheng, Linzhao, Civin, Curt I.

“…Notch signaling is implicated in stem cell self‐renewal, differentiation, and other developmental processes, and the Drosophila hairy and enhancer of split…”
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Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence by Kaplan, Ian M, Morisot, Sebastien, Heiser, Diane, Cheng, Wen-Chih, Kim, Min Jung, Civin, Curt I

“…Tristetraprolin (TTP, Zfp36, Nup475, Tis11) dramatically reduces the stability of target mRNAs by binding to AU-rich elements in their 3' untranslated regions…”
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Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas by Esni, Farzad, Ghosh, Bidyut, Biankin, Andrew V, Lin, John W, Albert, Megan A, Yu, Xiaobing, MacDonald, Raymond J, Civin, Curt I, Real, Francisco X, Pack, Michael A, Ball, Douglas W, Leach, Steven D

“…Notch signaling regulates cell fate decisions in a variety of adult and embryonic tissues, and represents a characteristic feature of exocrine pancreatic…”
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Late stage erythroid precursor production is impaired in mice with chronic inflammation by PRINCE, Olivier D, LANGDON, Jacqueline M, ANDREWS, Nancy C, XUE, Qian-Li, CIVIN, Curt I, WALSTON, Jeremy D, ROY, Cindy N, LAYMAN, Andrew J, PRINCE, Ian C, SABOGAL, Miguel, MAK, Howard H, BURGER, Alan E, CHEADLE, Chris, CHREST, Francis J, QILU YU

“…We and others have shown previously that over-expression of hepcidin antimicrobial peptide, independently of inflammation, induces several features of anemia…”
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Correlated miR-mRNA expression signatures of mouse hematopoietic stem and progenitor cell subsets predict "Stemness" and "Myeloid" interaction networks by Heiser, Diane, Tan, Yee Sun, Kaplan, Ian, Godsey, Brian, Morisot, Sebastien, Cheng, Wen-Chih, Small, Donald, Civin, Curt I

“…Several individual miRNAs (miRs) have been implicated as potent regulators of important processes during normal and malignant hematopoiesis. In addition, many…”
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Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age by McCranor, Bryan J, Langdon, Jacqueline M, Prince, Olivier D, Femnou, Laurette K, Berger, Alan E, Cheadle, Chris, Civin, Curt I, Kim, Airie, Rivera, Seth, Ganz, Tomas, Vaulont, Sophie, Xue, Qian-Li, Walston, Jeremy D, Roy, Cindy N

“…Anemia is common in older adults and associated with adverse health outcomes in epidemiological studies. A thorough understanding of the complex…”
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Activating Signals Dominate Inhibitory Signals in CD137L/IL-15 Activated Natural Killer Cells by HUA ZHANG, YONGZHI CUI, VOONG, Nga, SABATINO, Marianna, STRONCEK, Dave F, MORISOT, Sebastien, CIVIN, Curt I, WAYNE, Alan S, LEVINE, Bruce L, MACKALL, Crystal L

“…Natural killer (NK) cells can mediate potent antitumor effects, but factors regulating the efficiency of tumor lysis remain unclear. Studies in allogeneic stem…”
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A simple high-throughput technology enables gain-of-function screening of human microRNAs by Cheng, Wen-Chih, Kingsbury, Tami J, Wheelan, Sarah J, Civin, Curt I

“…MicroRNAs (miRs) regulate cellular processes by modulating gene expression. Although transcriptomic studies have identified numerous miRs differentially…”
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How Many Human Embryonic Stem Cell Lines Are Sufficient? A U.S. Perspective by Civin, Curt I., Rao, Mahendra S.

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