Search Results - "Civelek, Dilek Ozturk"

Circadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases by Civelek, Erkan, Ozturk Civelek, Dilek, Akyel, Yasemin Kubra, Kaleli Durman, Deniz, Okyar, Alper

“…Essential for survival and reproduction, the circadian timing system (CTS) regulates adaptation to cyclical changes such as the light/dark cycle, temperature…”
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The effects of P-glycoprotein inhibitor zosuquidar on the sex and time-dependent pharmacokinetics of parenterally administered talinolol in mice by Pala Kara, Zeliha, Ozturk Civelek, Dilek, Ozturk, Narin, Okyar, Alper

“…P-glycoprotein (P-gp) is an efflux protein that forms a tissue barrier and plays a role in the pharmacokinetics of drugs, limiting the influx of them and other…”
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Dosing-time dependent testicular toxicity of everolimus in mice by Ozturk, Narin, Ozturk Civelek, Dilek, Sancar, Serap, Kaptan, Engin, Pala Kara, Zeliha, Okyar, Alper

“…The circadian timing system controls many biological functions in mammals including drug metabolism and detoxification, cell cycle events, and thus may affect…”
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Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model by Aydin, Beyza Sümeyye, Sagiroglu, Ali Asram, Ozturk Civelek, Dilek, Gokce, Mustafa, Bahadori, Fatemeh

“…Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic…”
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Dosing‐time, feeding, and sex‐dependent variations of everolimus pharmacokinetics in mice by Ozturk Civelek, Dilek, Ozturk Seyhan, Narin, Akyel, Yasemin Kubra, Gazioglu, Isil, Pala Kara, Zeliha, Orman, Mehmet N., Okyar, Alper

“…Background Everolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly…”
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Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent by Zengin Kurt, Belma, Öztürk Civelek, Dilek, Çakmak, Elmas Begüm, Kolcuoğlu, Yakup, Şenol, Halil, Sağlık Özkan, Begüm Nurpelin, Dag, Aydan, Benkli, Kadriye

“…Sorafenib, a multiple kinase inhibitor, is widely used as a first-line treatment for hepatocellular carcinoma. However, there is a need for more effective…”
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Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice by Akyel, Yasemin Kubra, Ozturk Civelek, Dilek, Ozturk Seyhan, Narin, Gul, Seref, Gazioglu, Isil, Pala Kara, Zeliha, Lévi, Francis, Kavakli, Ibrahim Halil, Okyar, Alper

“…The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of…”
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Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents by Zengin Kurt, Belma, Celebi, Gulsen, Ozturk Civelek, Dilek, Angeli, Andrea, Akdemir, Atilla, Sonmez, Fatih, Supuran, Claudiu T.

“…In this study, sixty novel coumarin-monoterpene compounds were synthesized in two series [thirty-two compounds (12–43) bearing a triazole ring in the first…”
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Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies by Zengin Kurt, Belma, Altundağ, Özlem, Tokgöz, Merve Nur, Öztürk Civelek, Dilek, Tuncay, Fulya Oz, Cakmak, Ummuhan, Kolcuoğlu, Yakup, Akdemir, Atilla, Sönmez, Fatih

“…Totally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was…”
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Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies by Cakmak, Elmas Begum, Zengin Kurt, Belma, Ozturk Civelek, Dilek, Angeli, Andrea, Akdemir, Atilla, Sonmez, Fatih, Supuran, Claudiu T., Kucukislamoglu, Mustafa

“…[Display omitted] •27 novel quinoline derivatives were synthesized.•Their effects on the hCAI, CAII, CAIX, and CAXII isoforms were evaluated.•Their effects on…”
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Design of Biocompatible Multifunctional Hydrogels with Stearyl Methacrylate and Vinylpyrrolidone by Kılıç, Hüsna, Ceylan Tuncaboylu, Deniz, Argun, Aslıhan, Öztürk Civelek, Dilek

“…Biofunctionality and biocompatibility are essential when tissue or organs are supplemented or replaced with a polymer based material. Here, we prepared stearyl…”
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Synthesis, cytotoxic evaluation, and in silico studies of novel benzenesulfonamide-thiazolidinone derivatives against colorectal carcinoma by Zengin Kurt, Belma, Gökçe, Mustafa, Şenol, Halil, Öztürk Civelek, Dilek, Dandin, Gülnur, Gazioglu, Isil

“…•Thirteen novel benzenesulfonamide bearing 4-thiazolidinone derivatives were designed and synthesized.•The effects on colorectal cell line were…”
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Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies by Zengin Kurt, Belma, Altundağ, Özlem, Gökçe, Mustafa, Cakmak, Ummuhan, Tuncay, Fulya Oz, Kolcuoğlu, Yakup, Günaydın Akyıldız, Ayşenur, Akdemir, Atilla, Öztürk Civelek, Dilek, Sönmez, Fatih

“…•Sixteen novel naproxen urea compounds derivatives were designed and synthesized.•The effects on tyrosinase were evaluated and kinetic parameters were…”
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Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies by Demir-Yazıcı, Kübra, Trawally, Muhammed, Bua, Silvia, Öztürk-Civelek, Dilek, Akdemir, Atilla, Supuran, Claudiu T., Güzel-Akdemir, Özlen

“…[Display omitted] •Novel thiosemicarbazides (5a-5t) carrying 3-phenyl-1H-indole-5-sulfonamide moiety designed, synthesized, and assayed in enzyme inhibition…”
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Biocompatible carriers with vitaminD, PRP; effects on bone defects by Turgut, Cevat Tuğrul, Yaltirik, Mehmet, Civelek, Dilek Ozturk, Kotil, Tuğba, Gungor, Sevgi, Ozsoy, Yildiz, Okyar, Alper, Dirican, Ahmet

“…The aim of this study is to investigate the effects of biocompatible carriers containing Vitamin D and PRP on bone defects formed in rat calvaria. We planned…”
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