Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe

Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe

Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North Ameri...

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Bibliographic Details
Published in:International journal of environmental research and public health Vol. 19; no. 8; p. 4802
Main Authors: Rubió-Casadevall, Jordi, Ciurana, Elna, Puigdemont, Montserrat, Sanvisens, Arantza, Marruecos, Jordi, Miró, Josefina, Urban, Antoni, Palhua, Rosa-Lisset, Martín-Romero, Ferran, Ortiz-Duran, Maria Rosa, Marcos-Gragera, Rafael
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 15-04-2022
MDPI
Subjects:
Adenomatous polyposis coli
Age
Alphapapillomavirus
Epidemiology
Europe - epidemiology
Head & neck cancer
Human papillomavirus
Humans
Incidence
Infections
Mouth
Neoplasms
Oropharyngeal cancer
Oropharyngeal Neoplasms - epidemiology
Papillomaviridae
Papillomavirus Infections - epidemiology
Population
Prognosis
Software
Survival
Throat cancer
Tobacco
Trends
Tumors
Viruses
Europe
United States > US
Southern Europe
epidemiology
human papilloma virus
oropharyngeal cancer
p16
incidence
survival
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Summary:Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. We analyzed the epidemiology of OPC using the database from Girona's population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997-1999, 2003-2005, 2009-2011, and 2016-2018. Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016-2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC.
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ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19084802