Search Results - "Citrin, Deborah"

Recent Developments in Radiotherapy by Citrin, Deborah E

“…Technological development has led to the more precise delivery of radiation to tumors. Advances in sensitizing tumors to and protecting normal tissues from the…”
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Mechanisms of Normal Tissue Injury From Irradiation by Citrin, Deborah E., MD, Mitchell, James B., PhD

“…Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury;…”
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Biology of Radiation-Induced Lung Injury by Roy, Soumyajit, Salerno, Kilian E., Citrin, Deborah E.

“…Radiation-induced lung injury encompasses radiation-induced pneumonitis, inflammation of the lung which may manifest as a dose-limiting acute or subacute…”
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Recent Developments in Radiotherapy by Yan, Kelvin, Citrin, Deborah E

“…To the Editor: Citrin (Sept. 14 issue) 1 provides a comprehensive review of developments in radiotherapy. However, I think that advances in personalized…”
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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy by Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman

“…Abstract Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or…”
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Cellular senescence and radiation-induced pulmonary fibrosis by He, Yonghan, Thummuri, Dinesh, Zheng, Guangrong, Okunieff, Paul, Citrin, Deborah E., Vujaskovic, Zeljko, Zhou, Daohong

“…Radiation-induced pulmonary fibrosis (RIPF) is a serious treatment complication that affects about 9%–30% cancer patients receiving radiotherapy for thoracic…”
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Radiation Modifiers by Citrin, Deborah E.

“…Radiation therapy is one of the most commonly used treatments for cancer. Radiation modifiers are agents that alter tumor or normal tissue response to…”
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Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent Type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice by Pan, Jin, PhD, Li, Deguan, PhD, Xu, Yanfeng, PhD, Zhang, Junling, PhD, Wang, Yueying, BS, Chen, Mengyi, MS, Lin, Shuai, MS, Huang, Lan, BS, Chung, Eun Joo, PhD, Citrin, Deborah E., MD, Wang, Yingying, PhD, Hauer-Jensen, Martin, MD & PhD, Zhou, Daohong, MD, Meng, Aimin, MD

“…Abstract Purpose Ionizing radiation (IR)-induced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiotherapy. The goal of this…”
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Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma by Xie, Changqing, Duffy, Austin G, Brar, Gagandeep, Fioravanti, Suzanne, Mabry-Hrones, Donna, Walker, Melissa, Bonilla, Cecilia Monge, Wood, Bradford J, Citrin, Deborah E, Gil Ramirez, Elizabeth M, Escorcia, Freddy E, Redd, Bernadette, Hernandez, Jonathan M, Davis, Jeremy L, Gasmi, Billel, Kleiner, David, Steinberg, Seth M, Jones, Jennifer C, Greten, Tim F

“…The effectiveness of immune checkpoint inhibitors (ICI) is limited in pancreatic ductal adenocarcinoma (PDAC). We conducted a phase I study to evaluate the…”
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Short-Term Screening Assays for the Identification of Therapeutics for Cancer by Citrin, Deborah E

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Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy by ROSENBERG, Steven A, YANG, James C, MORTON, Kathleen E, LAURENCOT, Carolyn M, STEINBERG, Seth M, WHITE, Donald E, DUDLEY, Mark E, SHERRY, Richard M, KAMMULA, Udai S, HUGHES, Marybeth S, PHAN, Giao Q, CITRIN, Deborah E, RESTIFO, Nicholas P, ROBBINS, Paul F, WUNDERLICH, John R

“…Most treatments for patients with metastatic melanoma have a low rate of complete regression and thus overall survival in these patients is poor. We…”
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Hyperpolarized [1- 13 C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect by Scroggins, Bradley T, Matsuo, Masayuki, White, Ayla O, Saito, Keita, Munasinghe, Jeeva P, Sourbier, Carole, Yamamoto, Kazutoshi, Diaz, Vivian, Takakusagi, Yoichi, Ichikawa, Kazuhiro, Mitchell, James B, Krishna, Murali C, Citrin, Deborah E

“…To evaluate the potential of hyperpolarized [1- C]-pyruvate magnetic resonance spectroscopic imaging (MRSI) of prostate cancer as a predictive biomarker for…”
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Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens by DUDLEY, Mark E, YANG, James C, WUNDERLICH, John, RESTIFO, Nicholas P, THOMASIAN, Armen, DOWNEY, Stephanie G, SMITH, Franz O, KLAPPER, Jacob, MORTON, Kathleen, LAURENCOT, Carolyn, WHITE, Donald E, ROSENBERG, Steven A, SHERRY, Richard, HUGHES, Marybeth S, ROYAL, Richard, KAMMULA, Udai, ROBBINS, Paul F, JIANPING HUANG, CITRIN, Deborah E, LEITMAN, Susan F

“…The two approved treatments for patients with metastatic melanoma, interleukin (IL)-2 and dacarbazine, mediate objective response rates of 12% to 15%. We…”
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Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma by Goff, Stephanie L, Dudley, Mark E, Citrin, Deborah E, Somerville, Robert P, Wunderlich, John R, Danforth, David N, Zlott, Daniel A, Yang, James C, Sherry, Richard M, Kammula, Udai S, Klebanoff, Christopher A, Hughes, Marybeth S, Restifo, Nicholas P, Langhan, Michelle M, Shelton, Thomas E, Lu, Lily, Kwong, Mei Li M, Ilyas, Sadia, Klemen, Nicholas D, Payabyab, Eden C, Morton, Kathleen E, Toomey, Mary Ann, Steinberg, Seth M, White, Donald E, Rosenberg, Steven A

“…Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor regression in a majority of patients…”
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Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis by CITRIN, Deborah E, SHANKAVARAM, Uma, HORTON, Jason A, SHIELD, William, SHUPING ZHAO, ASANO, Hiroaki, WHITE, Ayla, SOWERS, Anastasia, THETFORD, Angela, EUN JOO CHUNG

“…Radiation is a commonly delivered therapeutic modality for cancer. The causes underlying the chronic, progressive nature of radiation injury in the lung are…”
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Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model by Chung, Eun Joo, Sowers, Anastasia, Thetford, Angela, McKay-Corkum, Grace, Chung, Su I., Mitchell, James B., Citrin, Deborah E.

“…Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation. Signaling of the mammalian target of rapamycin drives several…”
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Clonally expanded CD4⁺ T cells can produce infectious HIV-1 in vivo by Simonetti, Francesco R., Sobolewski, Michele D., Fyne, Elizabeth, Shao, Wei, Spindler, Jonathan, Hattori, Junko, Anderson, Elizabeth M., Watters, Sarah A., Hill, Shawn, Wu, Xiaolin, Wells, David, Su, Li, Luke, Brian T., Halvas, Elias K., Besson, Guillaume, Penrose, Kerri J., Yang, Zhiming, Kwan, Richard W., Van Waes, Carter, Uldrick, Thomas, Citrin, Deborah E., Kovacs, Joseph, Polis, Michael A., Rehm, Catherine A., Gorelick, Robert, Piatak, Michael, Keele, Brandon F., Kearney, Mary F., Coffin, John M., Hughes, Stephen H., Mellors, John W., Maldarelli, Frank

“…Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a major challenge. Most of the…”
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Mesenchymal stem cells inhibit cutaneous radiation‐induced fibrosis by suppressing chronic inflammation by Horton, Jason A., Hudak, Kathryn E., Chung, Eun Joo, White, Ayla O., Scroggins, Bradley T., Burkeen, Jeffrey F., Citrin, Deborah E.

“…Exposure to ionizing radiation (IR) can result in the development of cutaneous fibrosis, for which few therapeutic options exist. We tested the hypothesis that…”
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Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs by Prasanna, Pataje G. S., Aryankalayil, Molykutty, Citrin, Deborah E., Coleman, C. Norman

“…Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of…”
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Radioprotectors and Mitigators of Radiation‐Induced Normal Tissue Injury by Citrin, Deborah, Cotrim, Ana P., Hyodo, Fuminori, Baum, Bruce J., Krishna, Murali C., Mitchell, James B.

“…Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities…”
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