Search Results - "Cirotti, Claudia"

SRC Kinase in Glioblastoma: News from an Old Acquaintance by Cirotti, Claudia, Contadini, Claudia, Barilà, Daniela

“…Glioblastoma multiforme (GBM) is one of the most recalcitrant brain tumors characterized by a tumor microenvironment (TME) that strongly supports GBM growth,…”
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Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra by Stagni, Venturina, Cirotti, Claudia, Barilà, Daniela

“…Ataxia-telangiectasia mutated kinase (ATM) plays a central role in the DNA damage response (DDR) and mutations in its gene lead to the development of a rare…”
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Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma by Fianco, Giulia, Contadini, Claudia, Ferri, Alessandra, Cirotti, Claudia, Stagni, Venturina, Barilà, Daniela

“…Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is…”
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ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence? by Stagni, Venturina, Ferri, Alessandra, Cirotti, Claudia, Barilà, Daniela

“…Increasing evidence suggests a strong interplay between autophagy and genomic stability. Recently, several papers have demonstrated a molecular connection…”
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Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress by Cirotti, Claudia, Rizza, Salvatore, Giglio, Paola, Poerio, Noemi, Allega, Maria Francesca, Claps, Giuseppina, Pecorari, Chiara, Lee, Ji-Hoon, Benassi, Barbara, Barilà, Daniela, Robert, Caroline, Stamler, Jonathan S, Cecconi, Francesco, Fraziano, Maurizio, Paull, Tanya T, Filomeni, Giuseppe

“…The denitrosylase S -nitrosoglutathione reductase (GSNOR) has been suggested to sustain mitochondrial removal by autophagy (mitophagy), functionally linking S…”
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Identification and Biological Characterization of the Pyrazolo[3,4- d ]pyrimidine Derivative SI388 Active as Src Inhibitor by Contadini, Claudia, Cirotti, Claudia, Carbone, Anna, Norouzi, Mehrdad, Cianciusi, Annarita, Crespan, Emmanuele, Perini, Cecilia, Maga, Giovanni, Barilà, Daniela, Musumeci, Francesca, Schenone, Silvia

“…Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we…”
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nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis by Montagna, Costanza, Rizza, Salvatore, Cirotti, Claudia, Maiani, Emiliano, Muscaritoli, Maurizio, Musarò, Antonio, Carrí, Maria Teresa, Ferraro, Elisabetta, Cecconi, Francesco, Filomeni, Giuseppe

“…Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal muscle function due, at least in part, to S -nitrosylation of…”
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Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species by Schiavi, Alfonso, Cirotti, Claudia, Gerber, Lora-Sophie, Di Lauro, Giulia, Maglioni, Silvia, Shibao, Priscila Yumi Tanaka, Montresor, Sabrina, Kirstein, Janine, Petzsch, Patrick, Köhrer, Karl, Schins, Roel P. F., Wahle, Tina, Barilà, Daniela, Ventura, Natascia

“…Alzheimer’s disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex…”
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Mature Erythrocytes of Iguana iguana (Squamata, Iguanidae) Possess Functional Mitochondria by Di Giacomo, Giuseppina, Campello, Silvia, Corrado, Mauro, Di Giambattista, Livia, Cirotti, Claudia, Filomeni, Giuseppe, Gentile, Gabriele

“…Electron microscopy analyses of Iguana iguana blood preparations revealed the presence of mitochondria within erythrocytes with well-structured cristae…”
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S-Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis by Filomeni, Giuseppe, Cecconi, Francesco, Cozzolino, Mauro, Consales, Claudia, Cardaci, Simone, Montagna, Costanza, Cirotti, Claudia, Rizza, Salvatore, Carrì, Maria Teresa

“…Oxidative and nitrosative stresses have been reported as detrimental phenomena concurring to the onset of several neurodegenerative diseases. Here we reported…”
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S-Nitrosation and Ubiquitin-Proteasome System Interplay in Neuromuscular Disorders by Rizza, Salvatore, Montagna, Costanza, Di Giacomo, Giuseppina, Cirotti, Claudia, Filomeni, Giuseppe

“…Protein S-nitrosation is deemed as a prototype of posttranslational modifications governing cell signaling. It takes place on specific cysteine residues that…”
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ATM plays antioxidant, boosting mitophagy via denitrosylation by Cirotti, Claudia, Filomeni, Giuseppe

“…Mitophagy is a selective process aimed at removing damaged or burned-out mitochondria; it is activated upon different stimuli and plays a fundamental role in…”
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Fifty-Hertz Magnetic Field Affects the Epigenetic Modulation of the miR-34b/c in Neuronal Cells by Consales, Claudia, Cirotti, Claudia, Filomeni, Giuseppe, Panatta, Martina, Butera, Alessio, Merla, Caterina, Lopresto, Vanni, Pinto, Rosanna, Marino, Carmela, Benassi, Barbara

“…The exposure to extremely low-frequency magnetic fields (ELF-MFs) has been associated to increased risk of neurodegenerative diseases, although the underlying…”
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Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer by Contadini, Claudia, Ferri, Alessandra, Cirotti, Claudia, Stupack, Dwayne, Barilà, Daniela

“…Caspase-8 is a cysteine-aspartic acid protease that has been identified as an initiator caspase that plays an essential role in the extrinsic apoptotic…”
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Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy by Contadini, Claudia, Ferri, Alessandra, Di Martile, Marta, Cirotti, Claudia, Del Bufalo, Donatella, De Nicola, Francesca, Pallocca, Matteo, Fanciulli, Maurizio, Sacco, Francesca, Donninelli, Gloria, Capone, Alessia, Volpe, Elisabetta, Keller, Nadine, Miki, Shunichiro, Kawauchi, Daisuke, Stupack, Dwayne, Furnari, Frank, Barilà, Daniela

“…Caspase-8 is a cysteine protease that plays an essential role in apoptosis. Consistently with its canonical proapoptotic function, cancer cells may genetically…”
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NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma by Cirotti, Claudia, Taddei, Irene, Contadini, Claudia, Di Girolamo, Claudia, Pepe, Gerardo, De Bardi, Marco, Borsellino, Giovanna, Helmer-Citterich, Manuela, Barilà, Daniela

“…Glioblastoma is a severe brain tumor characterized by an extremely poor survival rate of patients. Glioblastoma cancer cells escape to standard therapeutic…”
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