Search Results - "Cirnaru, Maria‐Daniela"

An atlas of chromatin accessibility in the adult human brain by Fullard, John F, Hauberg, Mads E, Bendl, Jaroslav, Egervari, Gabor, Cirnaru, Maria-Daniela, Reach, Sarah M, Motl, Jan, Ehrlich, Michelle E, Hurd, Yasmin L, Roussos, Panos

“…Most common genetic risk variants associated with neuropsychiatric disease are noncoding and are thought to exert their effects by disrupting the function of…”
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Striatal Cholinergic Dysregulation after Neonatal Decrease in X‐Linked Dystonia Parkinsonism‐Related TAF1 Isoforms by Cirnaru, Maria‐Daniela, Creus‐Muncunill, Jordi, Nelson, Shareen, Lewis, Travis B., Watson, Jaime, Ellerby, Lisa M., Gonzalez‐Alegre, Pedro, Ehrlich, Michelle E.

“…ABSTRACT Background X‐linked dystonia parkinsonism is a generalized, progressive dystonia followed by parkinsonism with onset in adulthood and accompanied by…”
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Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse Models of Monogenic Dystonia by Melis, Chiara, Beauvais, Genevieve, Muntean, Brian S., Cirnaru, Maria‐Daniela, Otrimski, Garrett, Creus‐Muncunill, Jordi, Martemyanov, Kirill A., Gonzalez‐Alegre, Pedro, Ehrlich, Michelle E.

“…ABSTRACT Background Similar to some monogenic forms of dystonia, levodopa‐induced dyskinesia is a hyperkinetic movement disorder with abnormal nigrostriatal…”
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Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation by Cirnaru, Maria-Daniela, Song, Sicheng, Tshilenge, Kizito-Tshitoko, Corwin, Chuhyon, Mleczko, Justyna, Galicia Aguirre, Carlos, Benlhabib, Houda, Bendl, Jaroslav, Apontes, Pasha, Fullard, John, Creus-Muncunill, Jordi, Reyahi, Azadeh, Nik, Ali M, Carlsson, Peter, Roussos, Panos, Mooney, Sean D, Ellerby, Lisa M, Ehrlich, Michelle E

“…Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal…”
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Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington's Disease by Song, Sicheng, Creus Muncunill, Jordi, Galicia Aguirre, Carlos, Tshilenge, Kizito-Tshitoko, Hamilton, B Wade, Gerencser, Akos A, Benlhabib, Houda, Cirnaru, Maria-Daniela, Leid, Mark, Mooney, Sean D, Ellerby, Lisa M, Ehrlich, Michelle E

“…The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington's disease (HD), Parkinson's disease, X-linked…”
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LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation by Pischedda, Francesca, Cirnaru, Maria Daniela, Ponzoni, Luisa, Sandre, Michele, Biosa, Alice, Carrion, Maria Perez, Marin, Oriano, Morari, Michele, Pan, Lifeng, Greggio, Elisa, Bandopadhyay, Rina, Sala, Mariaelvina, Piccoli, Giovanni

“…Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons within the substantia nigra pars compacta and the presence of…”
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LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate by Belluzzi, Elisa, Gonnelli, Adriano, Cirnaru, Maria-Daniela, Marte, Antonella, Plotegher, Nicoletta, Russo, Isabella, Civiero, Laura, Cogo, Susanna, Carrion, Maria Perèz, Franchin, Cinzia, Arrigoni, Giorgio, Beltramini, Mariano, Bubacco, Luigi, Onofri, Franco, Piccoli, Giovanni, Greggio, Elisa

“…Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and…”
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Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain by Piccoli, Giovanni, Onofri, Franco, Cirnaru, Maria Daniela, Kaiser, Christoph J. O., Jagtap, Pravinkumar, Kastenmüller, Andreas, Pischedda, Francesca, Marte, Antonella, von Zweydorf, Felix, Vogt, Andreas, Giesert, Florian, Pan, Lifeng, Antonucci, Flavia, Kiel, Christina, Zhang, Mingjie, Weinkauf, Sevil, Sattler, Michael, Sala, Carlo, Matteoli, Michela, Ueffing, Marius, Gloeckner, Christian Johannes

“…Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that…”
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A Cell Surface Biotinylation Assay to Reveal Membrane-associated Neuronal Cues: Negr1 Regulates Dendritic Arborization by Pischedda, Francesca, Szczurkowska, Joanna, Cirnaru, Maria Daniela, Giesert, Florian, Vezzoli, Elena, Ueffing, Marius, Sala, Carlo, Francolini, Maura, Hauck, Stefanie M., Cancedda, Laura, Piccoli, Giovanni

“…A complex and still not comprehensively resolved panel of transmembrane proteins regulates the outgrowth and the subsequent morphological and functional…”
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Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling by Cirnaru, Maria-Daniela, Melis, Chiara, Fanutza, Tomas, Naphade, Swati, Tshilenge, Kizito-Tshitoko, Muntean, Brian S, Martemyanov, Kirill A, Plotkin, Joshua L, Ellerby, Lisa M, Ehrlich, Michelle E

“…The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be classified into striosome, also known as patch, and matrix, based on…”
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Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain by Civiero, Laura, Cirnaru, Maria Daniela, Beilina, Alexandra, Rodella, Umberto, Russo, Isabella, Belluzzi, Elisa, Lobbestael, Evy, Reyniers, Lauran, Hondhamuni, Geshanthi, Lewis, Patrick A., Van den Haute, Chris, Baekelandt, Veerle, Bandopadhyay, Rina, Bubacco, Luigi, Piccoli, Giovanni, Cookson, Mark R., Taymans, Jean‐Marc, Greggio, Elisa

“…Leucine‐rich repeat kinase 2 (LRRK2) is a causative gene for Parkinson's disease, but the physiological function and the mechanism(s) by which the cellular…”
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LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex by Cirnaru, Maria D, Marte, Antonella, Belluzzi, Elisa, Russo, Isabella, Gabrielli, Martina, Longo, Francesco, Arcuri, Ludovico, Murru, Luca, Bubacco, Luigi, Matteoli, Michela, Fedele, Ernesto, Sala, Carlo, Passafaro, Maria, Morari, Michele, Greggio, Elisa, Onofri, Franco, Piccoli, Giovanni

“…Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that…”
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Postnatal Conditional Deletion of IBcl11b/I in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease by Song, Sicheng, Creus Muncunill, Jordi, Galicia Aguirre, Carlos, Tshilenge, Kizito-Tshitoko, Hamilton, B. Wade, Gerencser, Akos A, Benlhabib, Houda, Cirnaru, Maria-Daniela, Leid, Mark, Mooney, Sean D, Ellerby, Lisa M, Ehrlich, Michelle E

“…The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington's disease (HD), Parkinson's disease, X-linked…”
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LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias by Stanic, Jennifer, Mellone, Manuela, Cirnaru, Maria Daniela, Perez-Carrion, Maria, Zianni, Elisa, Di Luca, Monica, Gardoni, Fabrizio, Piccoli, Giovanni

“…Levodopa (L-DOPA)-induced dyskinesias (LIDs) represent the major side effect in Parkinson's disease (PD) therapy. Leucine-rich repeat kinase 2 (LRRK2)…”
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Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D 1 Receptor Signaling by Cirnaru, Maria-Daniela, Melis, Chiara, Fanutza, Tomas, Naphade, Swati, Tshilenge, Kizito-Tshitoko, Muntean, Brian S, Martemyanov, Kirill A, Plotkin, Joshua L, Ellerby, Lisa M, Ehrlich, Michelle E

“…The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be classified into striosome, also known as patch, and matrix, based on…”
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The role of Negr1 in cortical development via NCAM-FGFR2 signaling by Pischedda, Francesca, Szczurkowska, Joanna, Daniela Cirnaru, Maria, Cancedda, Laura, Piccoli, Giovanni

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