Search Results - "Cipolla, Marilyn J."

The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation by Cipolla, Marilyn J, Liebeskind, David S, Chan, Siu-Lung

“…Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen outcome. Hypertension is prevalent in the stroke population and…”
Get full text

Inhibition of PAI (Plasminogen Activator Inhibitor)-1 Improves Brain Collateral Perfusion and Injury After Acute Ischemic Stroke in Aged Hypertensive Rats by Chan, Siu-Lung, Bishop, Nicole, Li, Zhaojin, Cipolla, Marilyn J

“…BACKGROUND AND PURPOSE—Aging and hypertension, comorbidities prevalent in the stroke population, are associated with poor collateral status and worsened stroke…”
Get full text

Stroke in Pregnancy and Preeclampsia: Effect of Low-Dose Aspirin Treatment on Collateral Flow Velocity and Cerebral Blood Flow Autoregulation During Ischemia in Rats by Cipolla, Marilyn J, Tremble, Sarah M

“…Experimental preeclampsia (ePE) has been shown to have worsened outcome from stroke. We investigated the effect of low-dose aspirin, known to prevent…”
Get full text

Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats by Cipolla, Marilyn J, Linfante, Italo, Abuchowski, Abe, Jubin, Ronald, Chan, Siu-Lung

“…Similar to patients with chronic hypertension, spontaneously hypertensive rats (SHR) develop fast core progression during middle cerebral artery occlusion…”
Get full text

The cerebral circulation during pregnancy: adapting to preserve normalcy by Johnson, Abbie C, Cipolla, Marilyn J

“…The adaptation of the brain and cerebral circulation to pregnancy are unique compared with other organs and circulatory systems, ultimately functioning to…”
Get full text

Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia by Johnson, Abbie Chapman, Tremble, Sarah M, Chan, Siu-Lung, Moseley, Janae, LaMarca, Babbette, Nagle, Keith J, Cipolla, Marilyn J

“…Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-threatening complication of pregnancy with unclear etiology. Magnesium…”
Get full text

Experimental Preeclampsia Causes Long-Lasting Hippocampal Vascular Dysfunction and Memory Impairment by Johnson, Abbie C, Tremble, Sarah M, Cipolla, Marilyn J

“…Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with memory impairment, cognitive decline and brain atrophy later in life in women…”
Get full text

Differential effect of gold nanoparticles on cerebrovascular function and biomechanical properties by Hunt, Ryan D., Sedighi, Omid, Clark, Wayne M., Doiron, Amber L., Cipolla, Marilyn J.

“…Human stroke serum (HSS) has been shown to impair cerebrovascular function, likely by factors released into the circulation after ischemia. 20 nm gold…”
Get full text

The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation by Cipolla, Marilyn J, Hunt, Ryan D, Liebeskind, David S, Tremble, Sarah M

“…Stroke interventions that increase collateral flow have the potential to salvage penumbral tissue and increase the number of patients eligible for reperfusion…”
Get full text

Retrospective study of medical student scholarship and career trajectory following a mentored preclinical cardiovascular summer research fellowship by Wahlberg, Kramer, Mughal, Amreen, Li, Zhaojin, Cipolla, Marilyn J, Cushman, Mary, Flyer, Jonathan N

“…ObjectivesDeveloping a preclinical training infrastructure for cardiovascular clinician-scientists is an academic workforce priority. The Cardiovascular…”
Get full text

Effect of hypertension and carotid occlusion on brain parenchymal arteriole structure and reactivity by Sweet, Julie G, Chan, Siu-Lung, Cipolla, Marilyn J

“…We studied the effect of hypertension and chronic hypoperfusion on brain parenchymal arteriole (PA) structure and function. PAs were studied isolated and…”
Get full text

Increased oxidized low‐density lipoprotein causes blood‐brain barrier disruption in early‐onset preeclampsia through LOX‐1 by Schreurs, Malou P. H., Hubel, Carl A., Bernstein, Ira M., Jeyabalan, Arun, Cipolla, Marilyn J.

“…Early‐onset preeclampsia (EPE) is a severe form of preeclampsia that involves life‐threatening neurological complications. However, the underlying mechanism by…”
Get full text

The Contribution of Normal Pregnancy to Eclampsia by Johnson, Abbie Chapman, Nagle, Keith J, Tremble, Sarah M, Cipolla, Marilyn J

“…Eclampsia, clinically defined as unexplained seizure in a woman with preeclampsia, is a life threatening complication unique to the pregnant state. However, a…”
Get full text

Dilation of Pregnant Rat Uterine Arteries with Phenols from Extra Virgin Olive Oil Is Endothelium-Dependent and Involves Calcium and Potassium Channels by Esposito, Milena, Gatto, Mariacarmela, Cipolla, Marilyn J, Bernstein, Ira M, Mandalà, Maurizio

“…During pregnancy, uterine vasculature undergoes significant circumferential growth to increase uterine blood flow, vital for the growing feto-placental unit…”
Get full text

Cerebral Blood Flow Autoregulation in Offspring From Experimentally Preeclamptic Rats and the Effect of Age by Whitaker, Emmett E, Johnson, Abbie C, Tremble, Sarah M, McGinn, Conor, DeLance, Nicole, Cipolla, Marilyn J

“…Preeclampsia is a hypertensive disorder of pregnancy that causes significant, long term cardiovascular effects for both the mother and offspring. A previous…”
Get full text

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1 by Merhi, Zaher, Thornton, Kimberley, Bonney, Elizabeth, Cipolla, Marilyn J., Charron, Maureen J., Buyuk, Erkan

“…Purpose The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age,…”
Get full text

Thomas Willis Lecture: Targeting Brain Arterioles for Acute Stroke Treatment by Cipolla, Marilyn J.

“…Cerebral infarction or ischemic death of brain tissue, most notably neurons, is a primary response to vascular occlusion that if minimized leads to better…”
Get full text

Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture by Langevin, Helene M., Churchill, David L., Cipolla, Marilyn J.

“…The mechanism of action of acupuncture remains largely unknown. The reaction to acupuncture needling known as ‘de qi’, widely viewed as essential to the…”
Get full text

HEMERA‐1 CarboxyHEMoglobin OxygEn Delivery for Evascularization in Acute Stroke: A Prospective, Randomized Phase 1 Clinical Trial by Linfante, Italo, Clark, Wayne, Haussen, Diogo C., Hanel, Ricardo, Reshi, Rwoof, Dabus, Guilherme, Jubin, Ronald, Roshan, Mona P., Belnap, Star, Nguyen, Thanh N., Grotta, James, Wicks, Robert, Cipolla, Marilyn J., Liebeskind, David S., Nogueira, Raul G.

“…Background PP‐007 is a polyethylene glycol (PEG)ylated bovine carboxyhemoglobin gas transfer molecule with pleotropic cytoprotective effects, vasodilatation,…”
Get full text

Mechanisms of Flow-Mediated Dilation of Pial Collaterals and the Effect of Hypertension by Li, Zhaojin, Cipolla, Marilyn J.

“…Leptomeningeal anastomoses are small distal anastomotic vessels also known as pial collaterals in the brain. These vessels redirect blood flow during an…”
Get full text