Search Results - "Cipolat, Sara"

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts by Scorrano, Luca, Frezza, Christian, Cipolat, Sara

“…Mitochondria participate in key metabolic reactions of the cell and regulate crucial signaling pathways including apoptosis. Although several approaches are…”
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Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling by Kasahara, Atsuko, Cipolat, Sara, Chen, Yun, Dorn, Gerald W., Scorrano, Luca

“…Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation is unclear. We found that mitochondrial fusion was required…”
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Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency by Cogliati, Sara, Frezza, Christian, Soriano, Maria Eugenia, Varanita, Tatiana, Quintana-Cabrera, Ruben, Corrado, Mauro, Cipolat, Sara, Costa, Veronica, Casarin, Alberto, Gomes, Ligia C., Perales-Clemente, Ester, Salviati, Leonardo, Fernandez-Silva, Patricio, Enriquez, Jose A., Scorrano, Luca

“…Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or…”
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Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis by Crisafulli, Sebastiano Giuseppe, Brajkovic, Simona, Cipolat Mis, Maria Sara, Parente, Valeria, Corti, Stefania

“…Amyotrophic lateral sclerosis (ALS) is a neurological disease characterized by the progressive loss of cortical, bulbar, and spinal motor neurons (MNs). The…”
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OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion by Frezza, Christian, Cipolat, Sara, Martins de Brito, Olga, Micaroni, Massimo, Beznoussenko, Galina V., Rudka, Tomasz, Bartoli, Davide, Polishuck, Roman S., Danial, Nika N., De Strooper, Bart, Scorrano, Luca

“…Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the…”
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Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling by Cipolat, Sara, Rudka, Tomasz, Hartmann, Dieter, Costa, Veronica, Serneels, Lutgarde, Craessaerts, Katleen, Metzger, Kristine, Frezza, Christian, Annaert, Wim, D'Adamio, Luciano, Derks, Carmen, Dejaegere, Tim, Pellegrini, Luca, D'Hooge, Rudi, Scorrano, Luca, De Strooper, Bart

“…Rhomboids, evolutionarily conserved integral membrane proteases, participate in crucial signaling pathways. Presenilin-associated rhomboid-like (PARL) is an…”
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Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility by Cipolat, Sara, Hoste, Esther, Natsuga, Ken, Quist, Sven R, Watt, Fiona M

“…Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this…”
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OPA1 Requires Mitofusin 1 to Promote Mitochondrial Fusion by Cipolat, Sara, de Brito, Olga Martins, Zilio, Barbara Dal, Scorrano, Luca, Korsmeyer, Stanley J.

“…The regulated equilibrium between mitochondrial fusion and fission is essential to maintain integrity of the organelle. Mechanisms of mitochondrial fusion are…”
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Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders by Mis, Maria Sara Cipolat, Brajkovic, Simona, Tafuri, Francesco, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania

“…The identification of the hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in the non-coding region of the C9ORF72 gene as the most frequent genetic cause…”
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Autophagy in motor neuron disease: Key pathogenetic mechanisms and therapeutic targets by Cipolat Mis, Maria Sara, Brajkovic, Simona, Frattini, Emanuele, Di Fonzo, Alessio, Corti, Stefania

“…Autophagy is a lysosome-dependant intracellular degradation process that eliminates long-lived proteins as well as damaged organelles from the cytoplasm. An…”
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Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility by Natsuga, Ken, Cipolat, Sara, Watt, Fiona M.

“…Mice lacking three epidermal barrier proteins—envoplakin, periplakin, and involucrin (EPI-/- mice)—have a defective cornified layer, reduced epidermal γδ T…”
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Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments by Di Marco Barros, Rafael, Roberts, Natalie A., Dart, Robin J., Vantourout, Pierre, Jandke, Anett, Nussbaumer, Oliver, Deban, Livija, Cipolat, Sara, Hart, Rosie, Iannitto, Maria Luisa, Laing, Adam, Spencer-Dene, Bradley, East, Philip, Gibbons, Deena, Irving, Peter M., Pereira, Pablo, Steinhoff, Ulrich, Hayday, Adrian

“…Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely…”
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Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation by De Palma, C, Falcone, S, Pisoni, S, Cipolat, S, Panzeri, C, Pambianco, S, Pisconti, A, Allevi, R, Bassi, M T, Cossu, G, Pozzan, T, Moncada, S, Scorrano, L, Brunelli, S, Clementi, E

“…During myogenic differentiation the short mitochondria of myoblasts change into the extensively elongated network observed in myotubes. The functional…”
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Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility by Natsuga, Ken, Cipolat, Sara, Watt, Fiona M

“…Mice lacking three epidermal barrier proteins-envoplakin, periplakin and involucrin-(EPI-/- mice) have a defective cornified layer, reduced epidermal γδ T…”
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Measuring mitochondrial shape changes and their consequences on mitochondrial involvement during apoptosis by Frezza, Christian, Cipolat, Sara, Scorrano, Luca

“…Mitochondria are key players in cell death following intrinsic and, in some cell types, extrinsic stimuli. The recruitment of the mitochondrial pathway results…”
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Understanding allergy and cancer risk: what are the barriers? by Hoste, Esther, Cipolat, Sara, Watt, Fiona M.

“…Hoste et al . discuss whether allergic immune responses, which have been observed to be protective against some types of cancer, can be activated to target…”
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KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules by Nachat, Rachida, Cipolat, Sara, Sevilla, Lisa M, Chhatriwala, Mariya, Groot, Karen R, Watt, Fiona M

“…Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been…”
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Exons 5–15 of Kazrin Are Dispensable for Murine Epidermal Morphogenesis and Homeostasis by Chhatriwala, Mariya K., Cipolat, Sara, Sevilla, Lisa M., Nachat, Rachida, Watt, Fiona M.

“…Kazrin binds to periplakin and ARVCF catenin, and regulates adhesion and differentiation of cultured human keratinocytes. To explore kazrin function in vivo,…”
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Over-expression of the cardioprotective kinase Akt modulates mitochondrial morphology by Hausenloy, Derek J, Davidson, Sean, Wynne, Abigail, Cipolat, Sara, Yellon, Derek M, Scorrano, Luca

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Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts by Frezza, Christian, Cipolat, Sara, Scorrano, Luca

“…Mitochondria participate in key metabolic reactions of the cell and regulate crucial signaling pathways including apoptosis. Although several approaches are…”
Get full text