Search Results - "Ciotti, M. T."

Endogenous Aβ causes cell death via early tau hyperphosphorylation by Amadoro, G, Corsetti, V, Ciotti, M.T, Florenzano, F, Capsoni, S, Amato, G, Calissano, P

“…Abstract Alzheimer's disease (AD) is characterized by Aβ overproduction and tau hyperphosphorylation. We report that an early, transient and site-specific…”
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Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation by Matrone, C, Marolda, R, Ciafrè, S, Ciotti, M.T, Mercanti, D, Calissano, P

“…The present study shows that increased Abeta production in hippocampal neurons, due to a failure of NGF signal, induces an unexpected phosphorylation of…”
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Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons by Amadoro, G, Serafino, A L, Barbato, C, Ciotti, M T, Sacco, A, Calissano, P, Canu, N

“…Although the role of the microtubule-binding domain of the tau protein in the modulation of microtubule assembly is widely established, other possible…”
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Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons by Barbato, C., Giacovazzo, G., Albiero, F., Scardigli, R., Scopa, C., Ciotti, M. T., Strimpakos, G., Coccurello, R., Ruberti, F.

“…MicroRNAs have emerged as regulators of brain development and function. Reduction of miR-101 expression has been reported in rodent hippocampus during ageing,…”
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NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease by Corsetti, V, Florenzano, F, Atlante, A, Bobba, A, Ciotti, M T, Natale, F, Della Valle, F, Borreca, A, Manca, A, Meli, G, Ferraina, C, Feligioni, M, D'Aguanno, S, Bussani, R, Ammassari-Teule, M, Nicolin, V, Calissano, P, Amadoro, G

“…Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzheimer's disease (AD) pathobiology. We reported that a 20-22…”
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Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells by Zona, Cristina, Teresa Ciotti, Maria, Avoli, Massimo

“…Whole-cell, voltage-clamp recordings were made from rat cerebellar granule cells in culture under experimental conditions designed to study voltage-gated Na +…”
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Glutamate Neurotoxicity in Rat Cerebellar Granule Cells: A Major Role for Xanthine Oxidase in Oxygen Radical Formation by Atlante, A., Gagliardi, S., Minervini, G. M., Ciotti, M. T., Marra, E., Calissano, P.

“…: To gain insight into the mechanism through which the neurotransmitter glutamate causally participates in several neurological diseases, in vitro cultured…”
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Gadolinium in human glioblastoma cells for gadolinium neutron capture therapy by DE STASIO, Gelsomina, CASALBORE, Patrizia, PERRET, Didier, MOGK, David W, PERFETTI, Paolo, MEHTA, Minesh P, MERCANTI, Delio, PALLINI, Roberto, GILBERT, Benjamin, SANITA, Francesca, CIOTTI, Maria Teresa, ROSI, Giancarlo, FESTINESI, Armando, LAROCCA, Luigi Maria, RINELLI, Alessandro

“…157Gd is a potential agent for neutron capture cancer therapy (GdNCT). We directly observed the microdistribution of Gd in cultured human glioblastoma cells…”
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Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones by Volonté, C, Ciotti, M.T, D’Ambrosi, N, Lockhart, B, Spedding, M

“…In previous studies (Volonté and Merlo, 1996. J. Neurosci. Res. 45, 183–193) basilen blue was shown to be a P2 receptor antagonist which abrogated…”
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Igf1 and Pacap rescue cerebellar granule neurons from apoptosis via a common transcriptional program by Maino, B, D’Agata, V, Severini, C, Ciotti, MT, Calissano, P, Copani, A, Chang, Y-C, DeLisi, C, Cavallaro, S

“…A shift of the delicate balance between apoptosis and survival-inducing signals determines the fate of neurons during the development of the central nervous…”
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AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons by Amadoro, G, Corsetti, V, Florenzano, F, Atlante, A, Ciotti, M.T, Mongiardi, M.P, Bussani, R, Nicolin, V, Nori, S.L, Campanella, M, Calissano, P

“…Abstract Functional as well as structural alterations in mitochondria size, shape and distribution are precipitating, early events in progression of…”
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Exposure to 50 Hz electromagnetic radiation promote early maturation and differentiation in newborn rat cerebellar granule neurons by Lisi, A., Ciotti, M.T., Ledda, M., Pieri, M., Zona, C., Mercanti, D., Rieti, S., Giuliani, L., Grimaldi, S.

“…The wish of this work is the study of the effect of electromagnetic (EMF) radiations at a frequency of 50 Hz on the development of cerebellar granule neurons…”
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Nerve growth factor derivative NGF61/100 promotes outgrowth of primary sensory neurons with reduced signs of nociceptive sensitization by Severini, C., Petrocchi Passeri, P., Ciotti, M.T., Florenzano, F., Petrella, C., Malerba, F., Bruni, B., D'Onofrio, M., Arisi, I., Brandi, R., Possenti, R., Calissano, P., Cattaneo, A.

“…Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease. However, the development of an NGF-based therapy is limited…”
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Signaling pathways activated by chemokine receptor CXCR2 and AMPA-type glutamate receptors and involvement in granule cells survival by Limatola, C, Ciotti, M.T, Mercanti, D, Santoni, A, Eusebi, F

“…We show that treatment of cerebellar granules with interleukin-8 (IL-8), growth-related gene product β (GROβ) or AMPA induced activation of PI3-K/Akt and of…”
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Adenosine and ADP prevent apoptosis in cultured rat cerebellar granule cells by Vitolo, O.V., Ciotti, M.T., Galli, C., Borsello, T., Calissano, P.

“…Cerebellar granule cells (CGCs) explanted in vitro undergo death via apoptosis when the concentration of potassium is shifted from 25 mM to 5 mM. We report…”
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Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage by Marolda, R., Ciotti, M.T., Matrone, C., Possenti, R., Calissano, P., Cavallaro, S., Severini, C.

“…Altered levels of Substance P (SP), a neuropeptide endowed with neuroprotective and anti-apoptotic properties, were found in brain areas and spinal fluid of…”
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SP protects cerebellar granule cells against β-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels by Pieri, M., Amadoro, G., Carunchio, I., Ciotti, M.T., Quaresima, S., Florenzano, F., Calissano, P., Possenti, R., Zona, C., Severini, C.

“…The tachykinin endecapeptide substance P (SP) has been demonstrated to exert a functional role in neurodegenerative disorders, including Alzheimer's disease…”
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Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models by Corsetti, V., Amadoro, G., Gentile, A., Capsoni, S., Ciotti, M.T., Cencioni, M.T., Atlante, A., Canu, N., Rohn, T.T., Cattaneo, A., Calissano, P.

“…Biochemical modifications of tau proteins have been proposed to be among the earliest neurobiological changes in Alzheimer's disease (AD) and correlate better…”
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Granule neuron DNA damage following deafferentation in adult rats cerebellar cortex : A lesion model by BORSELLO, T, DI LUZIO, A, CIOTTI, M. T, CALISSANO, P, GALLI, C

“…Neuronal programmed cell death is regulated by a neurotrophic supply from targets and afferent inputs. The relative contribution of each component varies…”
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Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF by Calissano, P, Amadoro, G, Matrone, C, Ciafrè, S, Marolda, R, Corsetti, V, Ciotti, M T, Mercanti, D, Di Luzio, A, Severini, C, Provenzano, C, Canu, N

“…The term trophic is widely used to indicate a general pro-survival action exerted on target cells by different classes of extracellular messengers, including…”
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