Search Results - "Ciocca, D. R."

Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1 by Khaleque, M A, Bharti, A, Gong, J, Gray, P J, Sachdev, V, Ciocca, D R, Stati, A, Fanelli, M, Calderwood, S K

“…Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the…”
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Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer by Parker, BS, Ciocca, DR, Bidwell, BN, Gago, FE, Fanelli, MA, George, J, Slavin, JL, Möller, A, Steel, R, Pouliot, N, Eckhardt, BL, Henderson, MA, Anderson, RL

“…Using the clinically relevant 4T1‐derived syngeneic murine model of spontaneous mammary metastasis to bone, we have identified the cysteine cathepsin inhibitor…”
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A Silver Staining Method for Single-cell Gel Assay by Nadin, Silvina B, Vargas-Roig, Laura M, Ciocca, Daniel R

“…The single-cell gel assay (comet assay) is a very useful microelectrophoretic technique for evaluation of DNA damage and repair in individual cells. Usually,…”
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Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy by Vargas‐Roig, Laura M., Gago, Francisco E., Tello, Olga, Aznar, Juan C., Ciocca, Daniel R.

“…Heat shock proteins (Hsps) are induced in vitro by several cytotoxic drugs; in human breast cancer cells these proteins appear to be involved in anti‐cancer…”
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Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications by Ciocca, D R, Clark, G M, Tandon, A K, Fuqua, S A, Welch, W J, McGuire, W L

“…Cell synthesis of heat shock (stress-response) proteins is increased by a variety of environmental and pathophysiological stressful conditions. The 70-kd heat…”
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Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIα for anthracycline chemotherapy in locally advanced breast cancer by ARPINO, G, CIOCCA, D. R, WEISS, H, ALLRED, D. C, DAGUERRE, P, VARGAS-ROIG, L, LEUZZI, M, GAGO, F, ELLEDGE, R, MOHSIN, S. K

“…Purpose.Laboratory evidence indicates that tumor growth depends on the balance between cell proliferation and cell death, and many anticancer agents may exert…”
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Galgo: a bi-objective evolutionary meta-heuristic identifies robust transcriptomic classifiers associated with patient outcome across multiple cancer types by Guerrero-Gimenez, M E, Fernandez-Muñoz, J M, Lang, B J, Holton, K M, Ciocca, D R, Catania, C A, Zoppino, F C M

“…Abstract Motivation Statistical and machine-learning analyses of tumor transcriptomic profiles offer a powerful resource to gain deeper understanding of tumor…”
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Heat shock proteins (HSPs) based anti-cancer vaccines by Ciocca, D R, Cayado-Gutierrez, N, Maccioni, M, Cuello-Carrion, F D

“…The importance of HSPs themselves in antigen presentation and cross-presentation remains controversial. Most studies agree that as part of their molecular…”
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Effect of neonatal chronic stress on expression of Hsp70 and oestrogen receptor alpha in the rat oviduct during development and the oestrous cycle by Mariani, ML, Ciocca, DR, Gonzalez Jatuff, AS, Souto, M

“…A chronic unpredictable stress model used to produce depressive disorders in adult rats was applied to neonatal rats to investigate whether this type of stress…”
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Response of human breast cancer cells to heat shock and chemotherapeutic drugs by CIOCCA, D. R, FUQUA, S. A. W, LOCK-LIM, S, TOFT, D. O, WELCH, W. J, MCGUIRE, W. L

“…Previous studies have shown that certain chemotherapeutic drugs are less effective on tumor cells when cells have been previously exposed to hyperthermia. In…”
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c‐erbB‐2 (HER‐2/neu) protein and drug resistance in breast cancer patients treated with induction chemotherapy by Vargas‐Roig, Laura M., Gago, Francisco E., Tello, Olga, Martin de Civetta, María T., Ciocca, Daniel R.

“…Expression of c‐erbB‐2 protein has been associated with poor prognosis and poor response to chemotherapy in breast cancer patients. In the present prospective…”
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Correlation of HER-2/neu amplification with expression and with other prognostic factors in 1103 breast cancers by Ciocca, D R, Fujimura, F K, Tandon, A K, Clark, G M, Mark, C, Lee-Chen, G J, Pounds, G W, Vendely, P, Owens, M A, Pandian, M R

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Constitutive expression of heat shock proteins hsp25 and hsp70 in the rat oviduct during neonatal development, the oestrous cycle and early pregnancy by Mariani, M L, Souto, M, Fanelli, M A, Ciocca, D R

“…Certain heat shock proteins are regulated by steroid hormones and are associated with oestrogen receptor function in reproductive tissues, indicating that…”
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Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study) by CIOCCA, D. R, GREEN, S, ELLEDGE, R. M, CLARK, G. M, PUGH, R, RAVDIN, P, LEW, D, MARTINO, S, OSBORNE, C. K

“…In this study, we tested the hypothesis that heat shock proteins (hsps) 27 and 70 are associated with clinical resistance to tamoxifen. hsp27 is, like…”
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Estrogen receptor, progesterone receptor, and HER-2/neu protein in breast cancers from pregnant patients by Elledge, R M, Ciocca, D R, Langone, G, McGuire, W L

“…Because the occurrence of breast cancer during pregnancy is uncommon and because the high levels of estrogens and progestins associated with pregnancy could…”
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The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients by OESTERREICH, S, HILSENBECK, S. G, CIOCCA, D. R, ALLRED, D. C, CLARK, G. M, CHAMNESS, G. C, OSBORNE, C. K, FUQUA, S. A. W

“…Heat shock protein 27 (hsp27) belongs to the family of heat shock proteins and is thought to be involved in thermotolerance, cell proliferation, drug…”
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Estrogen Receptors and Cell Proliferation in Breast Cancer by Ciocca, Daniel R, Fanelli, Mariel A

“…Most of the actions of estrogens on the normal and abnormal mammary cells are mediated via estrogen receptors (ERs), including control of cell proliferation;…”
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Serological detection of heat shock protein hsp27 in normal and breast cancer patients by Fanelli, M A, Cuello Carrión, F D, Dekker, J, Schoemaker, J, Ciocca, D R

“…Heat shock protein Mr 27,000 (hsp27) is found in many human breast cancer cells and tissues; its expression is associated with the presence of estrogen…”
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Measurement of steroid hormone receptors in breast cancer patients on tamoxifen by ENCARNACION, C. A, CIOCCA, D. R, MCGUIRE, W. L, CLARK, G. M, FUQUA, S. A. W, OSBORNE, C. K

“…Estrogen (ER) and progesterone receptor (PgR) positive breast tumors often respond to tamoxifen, but ultimately progress as they become tamoxifen resistant. An…”
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Immunological evidence for the identity between the hsp27 estrogen-regulated heat shock protein and the p29 estrogen receptor-associated protein in breast and endometrial cancer by CIOCCA, D. R, LUQUE, E. H

“…Previous studies have shown several similarities between an estrogen-regulated heat shock protein of 24,000-28,000 daltons (hsp27), and a cytoplasmic estrogen…”
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