Search Results - "Ciobanu, Nelly"
-
1
Author Correction: The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova
Published in Nature communications (29-10-2024)Get full text
Journal Article -
2
Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis
Published in PLoS medicine (03-05-2024)“…Emerging evidence suggests that shortened, simplified treatment regimens for rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment…”
Get full text
Journal Article -
3
The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova
Published in Nature communications (05-04-2024)“…The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on the reproductive fitness of circulating strains of MDR M…”
Get full text
Journal Article -
4
Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova
Published in Emerging infectious diseases (01-05-2023)“…Applying whole-genome-sequencing, we aimed to detect transmission events of multidrug-resistant/rifampin-resistant strains of Mycobacterium tuberculosis…”
Get full text
Journal Article -
5
Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection
Published in Nature communications (26-01-2024)“…There is still incomplete knowledge of which Mycobacterium tuberculosis ( Mtb) antigens can trigger distinct T cell responses at different stages of infection…”
Get full text
Journal Article -
6
Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis
Published in PLoS medicine (22-02-2022)“…The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of…”
Get full text
Journal Article -
7
High-dose isoniazid in the shorter-course multidrug-resistant tuberculosis regimen in the Republic of Moldova
Published in The European respiratory journal (01-10-2017)“…Since May 2016 the World Health Organization (WHO) has recommended the treatment of multidrug-resistant tuberculosis (MDR-TB) patients with a standardised…”
Get full text
Journal Article -
8
A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status
Published in BMC infectious diseases (07-01-2020)“…Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant…”
Get full text
Journal Article -
9
Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients
Published in Journal of microbiology, immunology and infection (01-10-2023)“…To assess associations between disease severity in index TB patients and QuantiFERON-TB Gold Plus (QFT-Plus) results in contacts, and predictors for QFT-Plus…”
Get full text
Journal Article -
10
Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation
Published in The European respiratory journal (01-10-2017)“…We are grateful for the response by E. Heldal to our correspondence. Similar to other reports [1] from the World Health Organization (WHO) Euro-Region we found…”
Get full text
Journal Article -
11
-
12
Predicting resistance to fluoroquinolones among patients with rifampicin-resistant tuberculosis using machine learning methods
Published in PLOS digital health (01-01-2022)“…Limited access to drug-susceptibility tests (DSTs) and delays in receiving DST results are challenges for timely and appropriate treatment of multi-drug…”
Get full text
Journal Article -
13
Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study
Published in JMIR research protocols (14-07-2021)“…The lack of accurate and efficient diagnostic devices for extensively drug-resistant tuberculosis (XDR-TB) makes it a severe threat to global public health. A…”
Get full text
Journal Article -
14
Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study
Published in The Lancet infectious diseases (01-02-2022)“…The WHO End TB Strategy requires drug susceptibility testing and treatment of all people with tuberculosis, but second-line diagnostic testing with line-probe…”
Get full text
Journal Article -
15
Identifying Mtb-Specific T Cell Epitopes Across the Spectrum of Tuberculosis Infection: Implications for Diagnostics and Vaccines
Published in The Journal of immunology (1950) (01-05-2024)“…Abstract The challenge in advancing tuberculosis (TB) diagnostics and vaccines arises from our limited understanding of diverse Mtb antigens triggering…”
Get full text
Journal Article -
16
Profile of gene mutations responsible for M.Tuberculosis resistance to antituberculosis drugs
Published in Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale (01-01-2024)“…The implementation of rapid diagnostic tests and drug susceptibility testing requires a complex approach to these methods. The pattern of gene mutations…”
Get full text
Journal Article -
17
-
18
Impact of Mycobacterium tuberculosis strain type on multidrug-resistant tuberculosis severity, Republic of Moldova
Published in The Journal of infection (01-12-2023)Get full text
Journal Article -
19
Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression model
Published in EBioMedicine (01-04-2024)“…Multidrug resistant tuberculosis (MDR-TB) represents a major public health concern in the Republic of Moldova, with an estimated 31% of new and 56% of…”
Get full text
Journal Article -
20
Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression modelResearch in context
Published in EBioMedicine (01-04-2024)“…Background: Multidrug resistant tuberculosis (MDR-TB) represents a major public health concern in the Republic of Moldova, with an estimated 31% of new and 56%…”
Get full text
Journal Article