Search Results - "Cingolani, H."

Pulmonary Capillary Wedge Pressure Augments Right Ventricular Pulsatile Loading by TEDFORD, Ryan J, HASSOUN, Paul M, LEDERER, David J, KASS, David A, MATHAI, Stephen C, GIRGIS, Reda E, RUSSELL, Stuart D, THIEMANN, David R, CINGOLANI, Oscar H, MUDD, James O, BORLAUG, Barry A, REDFIELD, Margaret M

“…Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly…”
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The Anrep effect: 100 years later by Cingolani, Horacio E, Pérez, Néstor G, Cingolani, Oscar H, Ennis, Irene L

“…Myocardial stretch elicits a rapid increase in developed force, which is mainly caused by an increase in myofilament calcium sensitivity (Frank-Starling…”
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Thrombospondins in the transition from myocardial infarction to heart failure by Kirk, Jonathan A, Cingolani, Oscar H

“…Abstract The heart's reaction to ischemic injury from a myocardial infarction involves complex cross-talk between the extra-cellular matrix (ECM) and different…”
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Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP–Protein Kinase G Modulation by Seo, Kinya, Rainer, Peter P, Lee, Dong-ik, Hao, Scarlett, Bedja, Djahida, Birnbaumer, Lutz, Cingolani, Oscar H, Kass, David A

“…RATIONALE:The heart is exquisitely sensitive to mechanical stimuli to adapt rapidly to physiological demands. In muscle lacking dystrophin, such as Duchenne…”
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Pressure-volume relation analysis of mouse ventricular function by Cingolani, Oscar H, Kass, David A

“…Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of instantaneous ventricular pressure-volume (P-V) relations to assess cardiac…”
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Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle by Cingolani, Oscar H, Kirk, Jonathan A, Seo, Kinya, Koitabashi, Norimichi, Lee, Dong-ik, Ramirez-Correa, Genaro, Bedja, Djahida, Barth, Andreas S, Moens, An L, Kass, David A

“…RATIONALE:One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular…”
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Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation by Watts, Vabren L, Sepulveda, Fernando M, Cingolani, Oscar H, Ho, Alice S, Niu, Xiaolin, Kim, Rosa, Miller, Karen L, Vandegaer, Koenraad, Bedja, Djahida, Gabrielson, Kathleen L, Rameau, Gerald, O'Rourke, Brian, Kass, David A, Barouch, Lili A

“…Abstract Rationale Stimulation of β3-adrenoreceptors (β3-AR) blunts contractility and improves chronic left ventricular function in hypertrophied and failing…”
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Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS) by De Giusti, V C, Caldiz, C I, Ennis, I L, Pérez, N G, Cingolani, H E, Aiello, E A

“…Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that…”
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The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium by Nolly, M.B, Caldiz, C.I, Yeves, A.M, Villa-Abrille, M.C, Morgan, P.E, Amado Mondaca, Nicolas, Portiansky, Enrique L, Chiappe de Cingolani, G.E, Cingolani, H.E, Ennis, I.L

“…Abstract Mineralocorticoid receptor (MR) antagonists decrease morbidity and mortality in heart failure patients for whom oxidative stress is usual; however,…”
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Biochemical and Mechanical Dysfunction in a Mouse Model of Desmin-Related Myopathy by Maloyan, Alina, Osinska, Hanna, Lammerding, Jan, Lee, Richard T, Cingolani, Oscar H, Kass, David A, Lorenz, John N, Robbins, Jeffrey

“…An R120G mutation in αB-crystallin (CryAB) causes desmin-related myopathy (DRM). In mice with cardiomyocyte-specific expression of the mutation, CryAB-mediated…”
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Cardiac Hypertrophy and the Wnt/Frizzled Pathway by Cingolani, Oscar H

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Cardiovascular Risks and Organ Damage in Secondary Hypertension by Cingolani, Oscar H.

“…Secondary hypertension is associated with increased cardiovascular risk and exaggerated target organ damage, not only due to the higher and more sustained…”
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In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy by Cingolani, Oscar H., Pérez, Néstor G., Ennis, Irene L., Álvarez, María C., Mosca, Susana M., Schinella, Guillermo R., Escudero, Eduardo M., Cónsole, Gloria, Cingolani, Horacio E.

“…Growing in vitro evidence suggests NHE-1, a known target for reactive oxygen species (ROS), as a key mediator in cardiac hypertrophy (CH). Moreover, NHE-1…”
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Increased Systolic Performance With Diastolic Dysfunction in Adult Spontaneously Hypertensive Rats by Cingolani, Oscar H, Yang, Xiao-Ping, Cavasin, Maria A, Carretero, Oscar A

“…ABSTRACT—Hypertensive heart disease is characterized by early development of hypertrophy and fibrosis that leads to heart failure (HF). HF develops in…”
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Brief Report: Antisynthetase Syndrome–Associated Myocarditis by Sharma, Kavita, MD, Orbai, Ana-Maria, MD, Desai, Dipan, DO, Cingolani, Oscar H., MD, Halushka, Marc K., MD, PhD, Christopher-Stine, Lisa, MD, MPH, Mammen, Andrew L., MD, PhD, Wu, Katherine C., MD, Zakaria, Sammy, MD, MPH

“…Abstract Background The antisynthetase (AS) syndrome is characterized by autoimmune myopathy, interstitial lung disease, cutaneous involvement, arthritis,…”
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The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species by De Giusti, V.C., Correa, M.V., Villa-Abrille, M.C., Beltrano, C., Yeves, A.M., de Cingolani, G.E. Chiappe, Cingolani, H.E., Aiello, E.A.

“…We have previously demonstrated the participation of reactive oxygen species (ROS) in the positive inotropic effect of a physiological concentration of…”
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Sexual dimorphism in cardiac norepinephrine spillover: a NET difference by Cingolani, Oscar H, Kaludercic, Nina, Paolocci, Nazareno

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Angiotensin II stimulates cardiac L-type Ca(2+) current by a Ca(2+)- and protein kinase C-dependent mechanism by Aiello, E A, Cingolani, H E

“…Angiotensin II (ANG II) evokes positive inotropic responses in various species. However, the effects of this peptide on L-type Ca(2+) currents (I(Ca)) are…”
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Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism by Niu, Xiaolin, MD, PhD, Watts, Vabren L., PhD, Cingolani, Oscar H., MD, Sivakumaran, Vidhya, PhD, Leyton-Mange, Jordan S., MD, Ellis, Carla L., MD, Miller, Karen L, Vandegaer, Konrad, BS, Bedja, Djahida, MS, Gabrielson, Kathleen L., DVM, PhD, Paolocci, Nazareno, MD, Kass, David A., MD, Barouch, Lili A., MD

“…Objectives The aim of this study was to determine whether activation of β3-adrenergic receptor (AR) and downstream signaling of nitric oxide synthase (NOS)…”
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Stretch-Induced Alkalinization of Feline Papillary Muscle: An Autocrine-Paracrine System by Cingolani, H.E, Alvarez, B.V, Ennis, I.L, Camilion de Hurtado, NA

“…Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known, however, about the intracellular pathways involved in the transmission…”
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