Search Results - "Cines, D.B."

The HIT Expert Probability (HEP) Score: a novel pre‐test probability model for heparin‐induced thrombocytopenia based on broad expert opinion by CUKER, A., AREPALLY, G., CROWTHER, M. A., RICE, L., DATKO, F., HOOK, K., PROPERT, K. J., KUTER, D. J., ORTEL, T. L., KONKLE, B. A., CINES, D. B.

“…Background: The diagnosis of heparin‐induced thrombocytopenia (HIT) is challenging. Over‐diagnosis and over‐treatment are common. Objectives: To develop a…”
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Clot penetration and retention by plasminogen activators promote fibrinolysis by Marcos-Contreras, O.A., Ganguly, K., Yamamoto, A., Shlansky-Goldberg, R., Cines, D.B., Muzykantov, V.R., Murciano, J.-C.

“…Administered Plasminogen Activators, e.g. Activase® or tPA, Reteplase® or Ret and Tenectase® or TNK relate with the clot structure depending on their…”
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Prothrombotic factors enhance heparin‐induced thrombocytopenia and thrombosis in vivo in a mouse model by REILLY, M. P., TAYLOR, S. M., FRANKLIN, C., SACHAIS, B. S., CINES, D. B., WILLIAMS, K. J., MCKENZIE, S. E.

“…Background: Heparin‐induced thrombocytopenia/thrombosis (HIT/T) is a common cause of life‐ and limb‐threatening thrombosis. The development of antibodies that…”
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Towards a diagnosis of heparin‐induced thrombocytopenia after cardiopulmonary bypass by Matthai, W. H., Cines, D. B.

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Management of Primary Immune Thrombocytopenia in Pregnancy by Bussel, J.B., Hou, M., Cines, D.B.

“…( N Engl J Med. 2023;389:540–548) Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immunoglobulin G antiplatelet antibodies that lead…”
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PB0351 Complement Activating Properties of Heparin Induced Thrombocytopenia (HIT) Antibodies as Surrogate Markers for Functional Assays by Myoung, S., Khandelwal, S., Francis, S., Poncz, M., Rauova, L., Cines, D.B., Arepally, G.

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PB1359 Fc Modified KKO Blocks Thrombosis in Heparin-Induced Thrombocytopenia (HIT), But not in Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) by Sarkar, A., Ngo, A., Khandelwal, S., Gollomp, K., Arepally, G., Cines, D.B., Rauova, L., Poncz, M.

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OC 76.1 Chadox1 Exposure-Induced Neutrophil-Activating Peptide 2 (NAP2) Antibodies: Murine-Based Insights into the Pathogenesis of Thrombosis with Thrombocytopenia Syndrome (TTS) by Rauova, L., Oberg, J., Field, C., Levine, N., Gollomp, K., Arepally, G., Cines, D.B., Cohen, T., Poncz, M.

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Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages by Joglekar, M., Khandelwal, S., Cines, D. B., Poncz, M., Rauova, L., Arepally, G. M.

“…Summary Background Heparin‐induced thrombocytopenia (HIT) is an iatrogenic complication of heparin therapy caused by antibodies to a self‐antigen, platelet…”
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Interlaboratory agreement in the monitoring of unfractionated heparin using the anti‐factor Xa‐correlated activated partial thromboplastin time by CUKER, A., PTASHKIN, B., KONKLE, B. A., PIPE, S. W., WHINNA, H. C., ZHENG, X. L., CINES, D. B., POLLAK, E. S.

“…Background: In an effort to improve interlaboratory agreement in the monitoring of unfractionated heparin (UFH), the College of American Pathologists (CAP)…”
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The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte‐bound vs. free fibrinolytics by GERSH, K. C., ZAITSEV, S., MUZYKANTOV, V., CINES, D. B., WEISEL, J. W.

“…Background:  Coupling fibrinolytic plasminogen activators to red blood cells (RBCs) has been proposed as an effective, yet safe method of thromboprophylaxis,…”
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Case 15-1995: A 70-year-old woman with atrial fibrillation and the rapid onset of hemorrhagic manifestations by Cines, D.B, Laposata, M

“…Presentation of Case A 70-year-old woman was admitted to the hospital because of obtundation, aphasia, and a right hemiparesis. She had a five-year history of…”
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Interlaboratory agreement in the monitoring of unfractionated heparin using the anti‐factor Xa‐correlated activated partial thromboplastin time: reply to a rebuttal by CUKER, A., CINES, D. B., POLLAK, E. S.

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Platelet and monocyte antigenic complexes in the pathogenesis of heparin‐induced thrombocytopenia (HIT) by RAUOVA, L., AREPALLY, G., McKENZIE, S. E., KONKLE, B. A., CINES, D. B., PONCZ, M.

“…Heparin‐induced thrombocytopenia (HIT) is an iatrogenic disorder that occurs in a small subset of patients receiving heparin. Twenty‐five per cent (or higher)…”
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Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies by Arepally, G.M., Kamei, S., Park, K.S., Kamei, K., Li, Z.Q., Liu, W., Siegel, D.L., Kisiel, W., Cines, D.B., Poncz, M.

“…Antibodies to PF4/heparin can be demonstrated in almost all patients with heparin-induced thrombocytopenia/thrombosis (HIT/HITT) and in some persons exposed to…”
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Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia by Ziporen, L., Li, Z.Q., Park, K.S., Sabnekar, P., Liu, W.Y., Arepally, G., Shoenfeld, Y., Kieber-Emmons, T., Cines, D.B., Poncz, M.

“…Heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy. Antibodies to platelet factor 4 (PF4)/heparin complexes have…”
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Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia by Ziporen, L., Li, Z.Q., Park, K.S., Sabnekar, P., Liu, W.Y., Arepally, G., Shoenfeld, Y., Kieber-Emmons, T., Cines, D.B., Poncz, M.

“…Heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy. Antibodies to platelet factor 4 (PF4)/heparin complexes have…”
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The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT) by Poncz, Mortimer, Rauova, Lubica, Cines, Douglas B

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Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells by GROBMYER, S. R, KUO, A, ORISHIMO, M, OKADA, S. S, CINES, D. B, BARNATHAN, E. S

“…Vascular injury induced by angioplasty is often followed by smooth muscle cell (SMC) proliferation, migration, and accumulation of extracellular matrix. Since…”
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Thermotaxis of human trophoblastic cells by Higazi, A.A.-R., Kniss, D., Manuppello, J., Barnathan, E.S., Cines, D.B.

“…The objective of this study was to determine whether cultured human trophoblasts migrate in response to changes in oxygen tension or temperature. Human…”
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