Relationship between plasma leptin, insulin and tumor necrosis factor alpha in obese children

1. To evaluate the relationship between plasma leptin and TNFalpha concentrations in obese children and to assess the differences between hyperinsulinemic and normoinsulinemic groups. 2. To evaluate the relationship between plasma leptin and insulin levels in obese children. 3. To investigate the TN...

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Bibliographic Details
Published in:	Journal of pediatric endocrinology & metabolism : JPEM Vol. 18; no. 3; p. 275
Main Authors:	Aycan, Zehra, Berberoğlu, Merih, Ocal, Gönül, Evliyaoglu, Olcay, Adiyaman, Pelin, Deda, Gülhis, Caksen, Hüseyin, Akar, Nejat, Karahan, Ceren, Cinas, Peyami, Bideci, Aysun
Format:	Journal Article
Language:	English
Published:	Germany 01-03-2005
Subjects:	Blood Glucose - analysis Body Mass Index Case-Control Studies Child Fasting Female Homeostasis Humans Hypoglycemic Agents - blood Insulin - blood Leptin - blood Male Obesity - immunology Obesity - physiopathology Tumor Necrosis Factor-alpha - analysis
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Summary:	1. To evaluate the relationship between plasma leptin and TNFalpha concentrations in obese children and to assess the differences between hyperinsulinemic and normoinsulinemic groups. 2. To evaluate the relationship between plasma leptin and insulin levels in obese children. 3. To investigate the TNFalpha G308A mutation in obese children. Body mass index (BMI), fasting plasma glucose and insulin levels, oral glucose tolerance test results, homeostasis model assessment of insulin resistance (HOMA-IR) results, and plasma leptin and TNFalpha concentrations were evaluated in obese children (n = 45) and age- and gender-matched, lean healthy controls (n = 40). In obese children the fasting insulin, HOMA-IR results, plasma leptin and TNFalpha concentrations were significantly higher than in controls (p <0.05). Furthermore, obese females showed higher plasma leptin and insulin resistance compared to obese males. While plasma leptin, TNFalpha levels and HOMA-IR results were similar in the prepubertal and pubertal groups, insulin levels were significantly higher in the pubertal group. Plasma leptin and TNFalpha concentrations were similar in hyperinsulinemic and normoinsulinemic obese children. In control children, plasma leptin concentrations showed a positive correlation with BMI, age, fasting insulin and HOMA-IR results. In obese children, plasma leptin levels did not correlate with BMI, fasting insulin or TNFalpha. Plasma leptin concentrations did not show any correlation with TNFalpha levels in obese children. Furthermore, plasma leptin and TNFalpha concentrations were similar in hyperinsulinemic and normoinsulinemic obese children.
ISSN:	0334-018X
DOI:	10.1515/JPEM.2005.18.3.275