Search Results - "Cinar, Resat"

The therapeutic potential of second and third generation CB1R antagonists by Cinar, Resat, Iyer, Malliga R., Kunos, George

“…Endocannabinoids acting via CB1 receptors (CB1R) play a critical role in regulating energy homeostasis, which was the rationale for the pharmaceutical…”
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Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD by Udi, Shiran, Hinden, Liad, Earley, Brian, Drori, Adi, Reuveni, Noa, Hadar, Rivka, Cinar, Resat, Nemirovski, Alina, Tam, Joseph

“…Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and…”
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Crystal Structure of the Human Cannabinoid Receptor CB2 by Li, Xiaoting, Hua, Tian, Vemuri, Kiran, Ho, Jo-Hao, Wu, Yiran, Wu, Lijie, Popov, Petr, Benchama, Othman, Zvonok, Nikolai, Locke, K’ara, Qu, Lu, Han, Gye Won, Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Wang, Jingjing, Wu, Meng, Katritch, Vsevolod, Zhao, Suwen, Kunos, George, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic…”
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Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes by Jourdan, Tony, Godlewski, Grzegorz, Cinar, Resat, Bertola, Adeline, Szanda, Gergő, Liu, Jie, Tam, Joseph, Han, Tiffany, Mukhopadhyay, Bani, Skarulis, Monica C, Ju, Cynthia, Aouadi, Myriam, Czech, Michael P, Kunos, George

“…George Kunos and his colleagues show in a rat model that endocannabinoid activation of the Nlrp3 inflammasome in macrophages results in death of pancreatic…”
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Cholesterol as a modulator of cannabinoid receptor CB2 signaling by Yeliseev, Alexei, Iyer, Malliga R., Joseph, Thomas T., Coffey, Nathan J., Cinar, Resat, Zoubak, Lioudmila, Kunos, George, Gawrisch, Klaus

“…Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity…”
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Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy by RAJESH, Mohanraj, BATKAI, Sándor, HASKO, Gyorgy, PACHER, Pál, KECHRID, Malek, MUKHOPADHYAY, Partha, LEE, Wen-Shin, HORVATH, Bela, HOLOVAC, Eileen, CINAR, Resat, LIAUDET, Lucas, MACKIE, Ken

“…Endocannabinoids and cannabinoid 1 (CB(1)) receptors have been implicated in cardiac dysfunction, inflammation, and cell death associated with various forms of…”
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Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy by Jourdan, Tony, Szanda, Gergő, Rosenberg, Avi Z, Tam, Joseph, Earley, Brian James, Godlewski, Grzegorz, Cinar, Resat, Liu, Ziyi, Liu, Jie, Ju, Cynthia, Pacher, Pál, Kunos, George

“…Significance Diabetic nephropathy is the leading cause of chronic kidney disease in the United States, and one of the most significant long-term complications…”
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Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization by Björnson, Elias, Mukhopadhyay, Bani, Asplund, Anna, Pristovsek, Nusa, Cinar, Resat, Romeo, Stefano, Uhlen, Mathias, Kunos, George, Nielsen, Jens, Mardinoglu, Adil

“…Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that is increasingly prevalent. We analyzed global gene expression profiling of 361 HCC tumors…”
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Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms by Mukhopadhyay, Bani, Schuebel, Kornel, Mukhopadhyay, Partha, Cinar, Resat, Godlewski, Grzegorz, Xiong, Keming, Mackie, Ken, Lizak, Martin, Yuan, Qiaoping, Goldman, David, Kunos, George

“…Hepatocellular carcinoma (HCC) has high mortality and no adequate treatment. Endocannabinoids interact with hepatic cannabinoid 1 receptors (CB1Rs) to promote…”
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Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance by Tam, Joseph, Cinar, Resat, Liu, Jie, Godlewski, Grzegorz, Wesley, Daniel, Jourdan, Tony, Szanda, Gergő, Mukhopadhyay, Bani, Chedester, Lee, Liow, Jeih-San, Innis, Robert B., Cheng, Kejun, Rice, Kenner C., Deschamps, Jeffrey R., Chorvat, Robert J., McElroy, John F., Kunos, George

“…Obesity-related leptin resistance manifests in loss of leptin’s ability to reduce appetite and increase energy expenditure. Obesity is also associated with…”
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Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis by Godlewski, Grzegorz, Cinar, Resat, Coffey, Nathan J., Liu, Jie, Jourdan, Tony, Mukhopadhyay, Bani, Chedester, Lee, Liu, Ziyi, Osei-Hyiaman, Douglas, Iyer, Malliga R., Park, Joshua K., Smith, Roy G., Iwakura, Hiroshi, Kunos, George

“…Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alcohol-seeking behavior, but an…”
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Chronic alcohol produces neuroadaptations to prime dorsal striatal learning by DePoy, Lauren, Daut, Rachel, Brigman, Jonathan L., MacPherson, Kathryn, Crowley, Nicole, Gunduz-Cinar, Ozge, Pickens, Charles L., Cinar, Resat, Saksida, Lisa M., Kunos, George, Lovinger, David M., Bussey, Timothy J., Camp, Marguerite C., Holmes, Andrew

“…Drug addictions including alcoholism are characterized by degradation of executive control over behavior and increased compulsive drug seeking. These profound…”
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Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors by Kundu, Biswajit, Dvorácskó, Szabolcs, Basu, Abhishek, Pommerolle, Lenny, Kim, Kyu Ah, Wood, Casey M, Gibbs, Eve, Behee, Madeline, Tarasova, Nadya I, Cinar, Resat, Iyer, Malliga R

“…The inhibition of soluble epoxide hydrolase (sEH) can reduce the level of dihydroxyeicosatrienoic acids (DHETs) effectively maintaining endogenous…”
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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice by Mock, Elliot D., Mustafa, Mohammed, Gunduz-Cinar, Ozge, Cinar, Resat, Petrie, Gavin N., Kantae, Vasudev, Di, Xinyu, Ogasawara, Daisuke, Varga, Zoltan V., Paloczi, Janos, Miliano, Cristina, Donvito, Giulia, van Esbroeck, Annelot C. M., van der Gracht, Anouk M. F., Kotsogianni, Ioli, Park, Joshua K., Martella, Andrea, van der Wel, Tom, Soethoudt, Marjolein, Jiang, Ming, Wendel, Tiemen J., Janssen, Antonius P. A., Bakker, Alexander T., Donovan, Colleen M., Castillo, Laura I., Florea, Bogdan I., Wat, Jesse, van den Hurk, Helma, Wittwer, Matthias, Grether, Uwe, Holmes, Andrew, van Boeckel, Constant A. A., Hankemeier, Thomas, Cravatt, Benjamin F., Buczynski, Matthew W., Hill, Matthew N., Pacher, Pal, Lichtman, Aron H., van der Stelt, Mario

“…N -acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical…”
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Network analyses identify liver‐specific targets for treating liver diseases by Lee, Sunjae, Zhang, Cheng, Liu, Zhengtao, Klevstig, Martina, Mukhopadhyay, Bani, Bergentall, Mattias, Cinar, Resat, Ståhlman, Marcus, Sikanic, Natasha, Park, Joshua K, Deshmukh, Sumit, Harzandi, Azadeh M, Kuijpers, Tim, Grøtli, Morten, Elsässer, Simon J, Piening, Brian D, Snyder, Michael, Smith, Ulf, Nielsen, Jens, Bäckhed, Fredrik, Kunos, George, Uhlen, Mathias, Boren, Jan, Mardinoglu, Adil

“…We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first…”
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Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase by Liu, Jie, Cinar, Resat, Xiong, Keming, Godlewski, Grzegorz, Jourdan, Tony, Lin, Yuhong, Ntambi, James M., Kunos, George

“…High-fat diet (HFD)–induced obesity and insulin resistance are associated with increased activity of the endocannabinoid/CB ₁ receptor (CB ₁R) system that…”
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Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction by Liu, Zhenhua, Yang, Nannan, Dong, Jie, Tian, Wotu, Chang, Lisa, Ma, Jinghong, Guo, Jifeng, Tan, Jieqiong, Dong, Ao, He, Kaikai, Zhou, Jingheng, Cinar, Resat, Wu, Junbing, Salinas, Armando G., Sun, Lixin, Kumar, Mantosh, Sullivan, Breanna T., Oldham, Braden B., Pitz, Vanessa, Makarious, Mary B., Ding, Jinhui, Kung, Justin, Xie, Chengsong, Hawes, Sarah L., Wang, Lupeng, Wang, Tao, Chan, Piu, Zhang, Zhuohua, Le, Weidong, Chen, Shengdi, Lovinger, David M., Blauwendraat, Cornelis, Singleton, Andrew B., Cui, Guohong, Li, Yulong, Cai, Huaibin, Tang, Beisha

“…Endocannabinoid (eCB), 2 -arachidonoyl-glycerol (2-AG), the most abundant eCB in the brain, regulates diverse neural functions. Here we linked multiple…”
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Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling by Tam, Joseph, Szanda, Gergő, Drori, Adi, Liu, Ziyi, Cinar, Resat, Kashiwaya, Yoshihiro, Reitman, Marc L., Kunos, George

“…In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are…”
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Synthetic cannabinoids induce acute lung inflammation via cannabinoid receptor 1 activation by Zawatsky, Charles N., Abdalla, Jasmina, Cinar, Resat

“…Synthetic cannabinoid (SC) use has persisted in the United States despite schedule-1 placement under the Synthetic Drug Abuse Prevention Act of 2012 [1]…”
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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report by Wolff, Daniel, Radojcic, Vedran, Lafyatis, Robert, Cinar, Resat, Rosenstein, Rachel K., Cowen, Edward W., Cheng, Guang-Shing, Sheshadri, Ajay, Bergeron, Anne, Williams, Kirsten M., Todd, Jamie L., Teshima, Takanori, Cuvelier, Geoffrey D.E., Holler, Ernst, McCurdy, Shannon R., Jenq, Robert R., Hanash, Alan M., Jacobsohn, David, Santomasso, Bianca D., Jain, Sandeep, Ogawa, Yoko, Steven, Philipp, Luo, Zhonghui Katie, Dietrich-Ntoukas, Tina, Saban, Daniel, Bilic, Ervina, Penack, Olaf, Griffith, Linda M., Cowden, Meredith, Martin, Paul J., Greinix, Hildegard T., Sarantopoulos, Stefanie, Socie, Gerard, Blazar, Bruce R., Pidala, Joseph, Kitko, Carrie L., Couriel, Daniel R., Cutler, Corey, Schultz, Kirk R., Pavletic, Steven Z., Lee, Stephanie J., Paczesny, Sophie

“…Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in part because of nonreversible fibrosis, which impacts physical…”
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