Search Results - "Cinalli, Ryan M."

Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency by Molotkov, Andrei, Mazot, Pierre, Brewer, J. Richard, Cinalli, Ryan M., Soriano, Philippe

“…Activation of the FGF signaling pathway during preimplantation development of the mouse embryo is known to be essential for differentiation of the inner cell…”
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GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK by Pae, Juhee, Cinalli, Ryan M., Marzio, Antonio, Pagano, Michele, Lehmann, Ruth

“…The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is…”
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish by Giraldez, Antonio J, Cinalli, Ryan M, Glasner, Margaret E, Enright, Anton J, Thomson, J. Michael, Baskerville, Scott, Hammond, Scott M, Bartel, David P, Schier, Alexander F

“…MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally. To block all miRNA formation in zebrafish, we generated maternal-zygotic…”
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Akt stimulates aerobic glycolysis in cancer cells by ELSTROM, Rebecca L, BAUER, Daniel E, THOMPSON, Craig B, BUZZAI, Monica, KARNAUSKAS, Robyn, HARRIS, Marian H, PLAS, David R, HONGMING ZHUANG, CINALLI, Ryan M, ALAVI, Abass, RUDIN, Charles M

“…Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this…”
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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival by Rathmell, Jeffrey C., Fox, Casey J., Plas, David R., Hammerman, Peter S., Cinalli, Ryan M., Thompson, Craig B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor by Fox, Casey J, Hammerman, Peter S, Cinalli, Ryan M, Master, Stephen R, Chodosh, Lewis A, Thompson, Craig B

“…Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation…”
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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis by Thompson, Craig B, Rathmell, Jeffrey C, Lindsten, Tullia, Zong, Wei-Xing, Cinalli, Ryan M

“…Bak and Bax are required and redundant regulators of an intrinsic mitochondrial cell death pathway. To analyze this pathway in T cell development and…”
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The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis by Kong, Mei, Fox, Casey J., Mu, James, Solt, Laura, Xu, Anne, Cinalli, Ryan M., Birnbaum, Morris J., Lindsten, Tullia, Thompson, Craig B.

“…Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here…”
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Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma by Rathmell, Jeffrey C., Elstrom, Rebecca L., Cinalli, Ryan M., Thompson, Craig B.

“…The mechanisms that regulate basal T cell size and metabolic activity are uncertain. Since the phosphatidylinositol‐3 phosphate kinase (PI3 K) and Akt (PKB)…”
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A spindle-independent cleavage pathway controls germ cell formation in Drosophila by Cinalli, Ryan M., Lehmann, Ruth

“…Emergence of primordial germ cells (PGCs) from the syncytial Drosophila embryo is not well understood. Lehmann and colleagues show that a cytokinetic furrow…”
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Germ Cells Are Forever by Cinalli, Ryan M., Rangan, Prashanth, Lehmann, Ruth

“…Germ cells are the only cell type capable of generating an entirely new organism. In order to execute germline-specific functions and to retain the capacity…”
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Polarization of the C. elegans Embryo by RhoGAP-Mediated Exclusion of PAR-6 from Cell Contacts by Anderson, Dorian C, Gill, Jason S, Cinalli, Ryan M, Nance, Jeremy

“…Early embryos of some metazoans polarize radially to facilitate critical patterning events such as gastrulation and asymmetric cell division; however, little…”
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T cell homeostasis requires G protein‐coupled receptor‐mediated access to trophic signals that promote growth and inhibit chemotaxis by Cinalli, Ryan M., Herman, Catherine E., Lew, Brian O., Wieman, Heather L., Thompson, Craig B., Rathmell, Jeffrey C.

“…Signals that regulate T cell homeostasis are not fully understood. G protein‐coupled receptors (GPCR), such as the chemokine receptors, may affect homeostasis…”
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Rab7 Prevents Growth Factor-Independent Survival by Inhibiting Cell-Autonomous Nutrient Transporter Expression by Edinger, Aimee L, Cinalli, Ryan M, Thompson, Craig B

“…Growth factor withdrawal results in the endocytosis and degradation of transporter proteins for glucose and amino acids. Here, we show that this process is…”
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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-κB activation by HAMMERMAN, Peter S, FOX, Casey J, CINALLI, Ryan M, XU, Anne, WAGNER, John D, LINDSTEN, Tullia, THOMPSON, Craig B

“…Pim-2 is a transcriptionally regulated oncogenic kinase that promotes cell survival in response to a wide variety of proliferative signals. Deregulation of…”
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The PP2A-Associated Protein alpha 4 Is an Essential Inhibitor of Apoptosis by Kong, Mei, Fox, Casey J, Mu, James, Solt, Laura, Xu, Anne, Cinalli, Ryan M, Birnbaum, Morris J, Lindsten, Tullia, Thompson, Craig B

“…Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here…”
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Contact-mediated radial polarization of the early C. elegans embryo by Nance, Jeremy, Anderson, Dorian C., Gill, Jason S., Cinalli, Ryan M.

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Analysis of Drosophila melanogaster pole cell formation by Cinalli, Ryan M

“…The Drosophila melanogaster germ line originates from a group of embryonic cells called the pole cells. These cells form within a posterior cytoplasm of the…”
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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation by Hammerman, Peter S, Fox, Casey J, Cinalli, Ryan M, Xu, Anne, Wagner, John D, Lindsten, Tullia, Thompson, Craig B

“…Pim-2 is a transcriptionally regulated oncogenic kinase that promotes cell survival in response to a wide variety of proliferative signals. Deregulation of…”
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The PP2A-associated protein [alpha]4 is an essential inhibitor of apoptosis by Kong, Mei, Fox, Casey J, Mu, James, Solt, Laura, Xu, Anne, Cinalli, Ryan M, Birnbaum, Morris J, Lindsten, Tullia, Thompson, Craig B

“…Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here…”
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