Search Results - "Cimas, Francisco J."

Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment by Juan, Alberto, Cimas, Francisco J, Bravo, Iván, Pandiella, Atanasio, Ocaña, Alberto, Alonso-Moreno, Carlos

“…Breast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for…”
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An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy by Juan, Alberto, Cimas, Francisco J., Bravo, Iván, Pandiella, Atanasio, Ocaña, Alberto, Alonso-Moreno, Carlos

“…Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating cancer. Active targeting NPs can be generated by conjugation with…”
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Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer by Cimas, Francisco J., Niza, Enrique, Juan, Alberto, Noblejas-López, María del Mar, Bravo, Iván, Lara-Sanchez, Agustín, Alonso-Moreno, Carlos, Ocaña, Alberto

“…Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation…”
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Mathematical modelling of the waning of anti-RBD IgG SARS-CoV-2 antibody titers after a two-dose BNT162b2 mRNA vaccination by Cimas, Francisco J, Torres, Javier, Ontañón, Jesús, de Cabo, Carlos, Lozano, Julia, Requena, María Ángeles, Blas, Joaquín, Rodríguez-García, José Luis, Mas, Antonio, Solera, Javier

“…After exposure to SARS-CoV-2 and/or vaccination there is an increase in serum antibody titers followed by a non-linear waning. Our aim was to find out if this…”
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Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion by Serrano-Oviedo, Leticia, Ortega-Muelas, Marta, García-Cano, Jesús, Valero, María Ll, Cimas, Francisco J, Pascual-Serra, Raquel, Fernandez-Aroca, Diego M, Roche, Olga, Ruiz-Hidalgo, María J, Belandia, Borja, Giménez-Bachs, José M, Salinas, Antonio S, Sanchez-Prieto, Ricardo

“…To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death…”
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The Gene Signature of Activated M-CSF-Primed Human Monocyte-Derived Macrophages Is IL-10-Dependent by Cuevas, Víctor D., Simón-Fuentes, Miriam, Orta-Zavalza, Emmanuel, Samaniego, Rafael, Sánchez-Mateos, Paloma, Escribese, María, Cimas, Francisco J., Bustos, Matilde, Pérez-Diego, Mario, Ocaña, Alberto, Domínguez-Soto, Ángeles, Vega, Miguel A., Corbí, Ángel L.

“…During inflammatory responses, monocytes are recruited into inflamed tissues, where they become monocyte-derived macrophages and acquire pro-inflammatory and…”
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Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors by Alcaraz-Sanabria, Ana, Baliu-Piqué, Mariona, Saiz-Ladera, Cristina, Rojas, Katerin, Manzano, Aránzazu, Marquina, Gloria, Casado, Antonio, Cimas, Francisco J, Pérez-Segura, Pedro, Pandiella, Atanasio, Gyorffy, Balázs, Ocana, Alberto

“…There is an unmet need for new therapies in metastatic ovarian cancer and basal-like breast cancer since no curative therapies are currently available…”
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Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation by Noblejas-López, María Del Mar, Baliu-Piqué, Mariona, Nieto-Jiménez, Cristina, Cimas, Francisco J, Morafraile, Esther C, Pandiella, Atanasio, Corbi, Ángel L, Győrffy, Balázs, Ocaña, Alberto

“…Targeting the innate immune system has attracted attention with the development of anti- CD47 antibodies. Anti-CD47 antibodies block the inhibition of the…”
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Effect of Crocetin on Basal Lipolysis in 3T3-L1 Adipocytes by Cimas, Francisco J, De la Cruz-Morcillo, Miguel Ángel, Cifuentes, Carmen, Moratalla-López, Natalia, Alonso, Gonzalo L, Nava, Eduardo, Llorens, Sílvia

“…Crocetin (CCT) is a natural saffron-derived apocarotenoid that possesses healthy properties such as anti-adipogenic, anti-inflammatory, and antioxidant…”
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Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer by Saiz-Ladera, Cristina, Baliu-Piqué, Mariona, Cimas, Francisco J., Manzano, Aránzazu, García-Barberán, Vanesa, Camarero, Santiago Cabezas, Hinojal, Gonzalo Fernández, Pandiella, Atanasio, Győrffy, Balázs, Stewart, David, Cruz-Hernández, Juan J., Pérez-Segura, Pedro, Ocana, Alberto

“…Targeting the immune system has emerged as an effective therapeutic strategy for the treatment of various tumor types, including Head and Neck Squamous Cell…”
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Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer by Domínguez-Jurado, Elena, Cimas, Francisco J., Castro-Osma, José Antonio, Juan, Alberto, Lara-Sánchez, Agustín, Rodríguez-Diéguez, Antonio, Shafir, Alexandr, Ocaña, Alberto, Alonso-Moreno, Carlos

“…Despite some limitations such as long-term side effects or the potential presence of intrinsic or acquired resistance, platinum compounds are key therapeutic…”
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Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis by Serrano-Oviedo, Leticia, Ph.D, Giménez-Bachs, José M., Ph.D., M.D, Nam-Cha, Syongh Y., M.D, Cimas, Francisco J., Ph.D, García-Cano, Jesús, Ph.D, Sánchez-Prieto, Ricardo, Ph.D, Salinas-Sánchez, Antonio S., Ph.D., M.D

“…Abstract Objectives To determine the expression status of several proteins related to VHL gene function and its relationship with common clinicopathological…”
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Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer by Guillén Díaz-Maroto, Natalia, Sanz-Pamplona, Rebeca, Berdiel-Acer, Mireia, Cimas, Francisco J, García, Elena, Gonçalves-Ribeiro, Samuel, Albert, Nerea, Garcia-Vicién, Gemma, Capella, Gabriel, Moreno, Victor, Salazar, Ramon, Villanueva, Alberto, Molleví, David G

“…The aim of the study is blocking the recruitment of a protective stroma by altering the crosstalk between normal stromal cells and tumor cells for stripping…”
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Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1 by Cimas, Francisco J., Manzano, Arancha, Baliu-Piqué, Mariona, García-Gil, Elena, Pérez-Segura, Pedro, Nagy, Ádám, Pandiella, Atanasio, Győrffy, Balázs, Ocana, Alberto

“…Treatment with anti-PD-L1 antibodies has shown efficacy in basal-like breast cancer. In this context, identification of pre-activated immune tumors is a main…”
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TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response by Kim, Taewoo, Johnston, Jessica, Castillo-Lluva, Sonia, Cimas, Francisco J, Hamby, Stephen, Gonzalez-Moreno, Santiago, Villarejo-Campos, Pedro, Goodall, Alison H, Velasco, Guillermo, Ocana, Alberto, Muthana, Munitta, Kiss-Toth, Endre

“…Molecular mechanisms that regulate tumor-associated macrophage (TAM) phenotype and function are incompletely understood. The pseudokinase TRIB1 has been…”
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In silico transcriptomic mapping of integrins and immune activation in Basal-like and HER2+ breast cancer by Rojas, Katerin, Baliu-Piqué, Mariona, Manzano, Aránzazu, Saiz-Ladera, Cristina, García-Barberán, Vanesa, Cimas, Francisco J., Pérez-Segura, Pedro, Pandiella, Atanasio, Győrffy, Balázs, Ocana, Alberto

“…Purpose Integrins, transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions, have been linked to several cancer-associated…”
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P38 MAPK and Radiotherapy: Foes or Friends? by García-Flores, Natalia, Jiménez-Suárez, Jaime, Garnés-García, Cristina, Fernández-Aroca, Diego M, Sabater, Sebastia, Andrés, Ignacio, Fernández-Aramburo, Antonio, Ruiz-Hidalgo, María José, Belandia, Borja, Sanchez-Prieto, Ricardo, Cimas, Francisco J

“…Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways…”
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The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer by Orea-Soufi, Alba, Castillo-Lluva, Sonia, Salvador-Tormo, Nélida, Martín-Cabrera, Paola, Recuero, Silvia, Gabicagogeascoa, Estíbaliz, Moreno-Valladares, Manuel, Mendiburu-Eliçabe, Marina, Blanco-Gómez, Adrián, Ramos-Pittol, José Miguel, García-Taboada, Elena, Ocaña, Alberto, Cimas, Francisco J., Matheu, Ander, Álvarez-López, Isabel, Velasco, Guillermo, Lorente, Mar

“…Background: Tribbles pseudokinase 3 (TRIB3) has been proposed to both promote and restrict cancer generation and progression. However, the precise mechanisms…”
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Hepatitis C Virus RNA-Dependent RNA Polymerase Interacts with the Akt/PKB Kinase and Induces Its Subcellular Relocalization by Valero, María Llanos, Sabariegos, Rosario, Cimas, Francisco J, Perales, Celia, Domingo, Esteban, Sánchez-Prieto, Ricardo, Mas, Antonio

“…Hepatitis C virus (HCV) interacts with cellular components and modulates their activities for its own benefit. These interactions have been postulated as a…”
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Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance by García-Cano, Jesús, Ambroise, Gorbatchev, Pascual-Serra, Raquel, Carrión, Maria Carmen, Serrano-Oviedo, Leticia, Ortega-Muelas, Marta, Cimas, Francisco J, Sabater, Sebastià, Ruiz-Hidalgo, María José, Sanchez Perez, Isabel, Mas, Antonio, Jalón, Félix A, Vazquez, Aimé, Sánchez-Prieto, Ricardo

“…Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new therapeutic strategies to cisplatin resistance, we…”
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