Search Results - "Cillo, Anthony R."

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer by Cillo, Anthony R., Kürten, Cornelius H.L., Tabib, Tracy, Qi, Zengbiao, Onkar, Sayali, Wang, Ting, Liu, Angen, Duvvuri, Umamaheswar, Kim, Seungwon, Soose, Ryan J., Oesterreich, Steffi, Chen, Wei, Lafyatis, Robert, Bruno, Tullia C., Ferris, Robert L., Vignali, Dario A.A.

“…Head and neck squamous cell carcinoma (HNSCC) arises through exposure to environmental carcinogens or malignant transformation by human papillomavirus (HPV)…”
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B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma by Ruffin, Ayana T., Cillo, Anthony R., Tabib, Tracy, Liu, Angen, Onkar, Sayali, Kunning, Sheryl R., Lampenfeld, Caleb, Atiya, Huda I., Abecassis, Irina, Kürten, Cornelius H. L., Qi, Zengbiao, Soose, Ryan, Duvvuri, Umamaheswar, Kim, Seungwon, Oesterrich, Steffi, Lafyatis, Robert, Coffman, Lan G., Ferris, Robert L., Vignali, Dario A. A., Bruno, Tullia C.

“…Current immunotherapy paradigms aim to reinvigorate CD8 + T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here,…”
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Quantification of HIV-1 latency reversal in resting CD4⁺ T cells from patients on suppressive antiretroviral therapy by Cillo, Anthony R., Sobolewski, Michele D., Bosch, Ronald J., Fyne, Elizabeth, Piatak, Michael, Coffin, John M., Mellors, John W.

“…Reversal of proviral latency is being pursued as a curative strategy for HIV-1 infection. Recent clinical studies of in vivo administration of the histone…”
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Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART by Wiegand, Ann, Spindler, Jonathan, Hong, Feiyu F., Shao, Wei, Cyktor, Joshua C., Cillo, Anthony R., Halvas, Elias K., Coffin, John M., Mellors, John W., Kearney, Mary F.

“…Little is known about the fraction of human immunodeficiency virus type 1 (HIV-1) proviruses that express unspliced viral RNA in vivo or about the levels of…”
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Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing by Kürten, Cornelius H. L., Kulkarni, Aditi, Cillo, Anthony R., Santos, Patricia M., Roble, Anna K., Onkar, Sayali, Reeder, Carly, Lang, Stephan, Chen, Xueer, Duvvuri, Umamaheswar, Kim, Seungwon, Liu, Angen, Tabib, Tracy, Lafyatis, Robert, Feng, Jian, Gao, Shou-Jiang, Bruno, Tullia C., Vignali, Dario A. A., Lu, Xinghua, Bao, Riyue, Vujanovic, Lazar, Ferris, Robert L.

“…Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor…”
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Novel Assays for Measurement of Total Cell-Associated HIV-1 DNA and RNA by Hong, Feiyu, Aga, Evgenia, Cillo, Anthony R, Yates, Aarika L, Besson, Guillaume, Fyne, Elizabeth, Koontz, Dianna L, Jennings, Cheryl, Zheng, Lu, Mellors, John W

“…Although a number of PCR-based quantitative assays for measuring HIV-1 persistence during suppressive antiretroviral therapy (ART) have been reported, a…”
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A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies by Sun, Zhe, Chen, Li, Xin, Hongyi, Jiang, Yale, Huang, Qianhui, Cillo, Anthony R., Tabib, Tracy, Kolls, Jay K., Bruno, Tullia C., Lafyatis, Robert, Vignali, Dario A. A., Chen, Kong, Ding, Ying, Hu, Ming, Chen, Wei

“…The recently developed droplet-based single-cell transcriptome sequencing (scRNA-seq) technology makes it feasible to perform a population-scale scRNA-seq…”
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Which therapeutic strategy will achieve a cure for HIV-1? by Cillo, Anthony R, Mellors, John W

“…•Eradication, functional, and hybrid cures for HIV-1 are under investigation.•‘Kick and kill’ has been the most intensively studied curative strategy to…”
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Associations between HIV-1 DNA copy number, proviral transcriptional activity, and plasma viremia in individuals off or on suppressive antiretroviral therapy by Hong, Feiyu, Jacobs, Jana L., Aga, Evgenia, Cillo, Anthony R., Fyne, Elizabeth, Koontz, Dianna L., Zheng, Lu, Mellors, John W.

“…The relationships between HIV-1 DNA copy number, proviral transcriptional activity, and residual plasma viremia in individuals off and on ART are not well…”
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Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding by Andrews, Lawrence P, Somasundaram, Ashwin, Moskovitz, Jessica M, Szymczak-Workman, Andrea L, Liu, Chang, Cillo, Anthony R, Lin, Huang, Normolle, Daniel P, Moynihan, Kelly D, Taniuchi, Ichiro, Irvine, Darrell J, Kirkwood, John M, Lipson, Evan J, Ferris, Robert L, Bruno, Tullia C, Workman, Creg J, Vignali, Dario A A

“…Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte activation gene-3 (LAG3) signaling is regulated by a disintegrin and…”
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Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy by Cillo, Anthony R, Krishnan, Supriya, McMahon, Deborah K, Mitsuyasu, Ronald T, Para, Michael F, Mellors, John W

“…The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte…”
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Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone by Cillo, Anthony R, Kirkwood, John M

“…Combination immunotherapy improves outcomes in metastatic melanoma, but the underlying mechanisms remain unclear. In this issue of Cancer Cell, Wang et al…”
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Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer by Overacre-Delgoffe, Abigail E., Bumgarner, Hannah J., Cillo, Anthony R., Burr, Ansen H.P., Tometich, Justin T., Bhattacharjee, Amrita, Bruno, Tullia C., Vignali, Dario A.A., Hand, Timothy W.

“…The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Here, we examined the…”
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Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy by Andrews, Lawrence P, Cillo, Anthony R, Karapetyan, Lilit, Kirkwood, John M, Workman, Creg J, Vignali, Dario A A

“…Immunotherapy targeting coinhibitory receptors has been highly successful in treating a wide variety of malignancies; however, only a subset of patients…”
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Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 by Grebinoski, Stephanie, Zhang, Qianxia, Cillo, Anthony R., Manne, Sasikanth, Xiao, Hanxi, Brunazzi, Erin A., Tabib, Tracy, Cardello, Carly, Lian, Christine G., Murphy, George F., Lafyatis, Robert, Wherry, E. John, Das, Jishnu, Workman, Creg J., Vignali, Dario A. A.

“…Impaired chronic viral and tumor clearance has been attributed to CD8 + T cell exhaustion, a differentiation state in which T cells have reduced and altered…”
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Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks by Cillo, Anthony R, Mukherjee, Elina, Bailey, Nathanael G, Onkar, Sayali, Daley, Jessica, Salgado, Claudia, Li, Xiang, Liu, Dongyan, Ranganathan, Sarangarajan, Burgess, Melissa, Sembrat, John, Weiss, Kurt, Watters, Rebecca, Bruno, Tullia C, Vignali, Dario A A, Bailey, Kelly M

“…Ewing sarcoma and osteosarcoma are primary bone sarcomas occurring most commonly in adolescents. Metastatic and relapsed disease are associated with dismal…”
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Ultrabithorax confers spatial identity in a context-specific manner in the Drosophila postembryonic ventral nervous system by Marin, Elizabeth C, Dry, Katie E, Alaimo, Danielle R, Rudd, Kirstin T, Cillo, Anthony R, Clenshaw, Michael E, Negre, Nicolas, White, Kevin P, Truman, James W

“…In holometabolous insects such as Drosophila melanogaster, neuroblasts produce an initial population of diverse neurons during embryogenesis and a much larger…”
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Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts by Lucero, Carissa M, Fallert Junecko, Beth, Klamar, Cynthia R, Sciullo, Lauren A, Berendam, Stella J, Cillo, Anthony R, Qin, Shulin, Sui, Yongjun, Sanghavi, Sonali, Murphey-Corb, Michael A, Reinhart, Todd A

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8 + T cells to promote antitumor immunity by Cillo, Anthony R, Cardello, Carly, Shan, Feng, Karapetyan, Lilit, Kunning, Sheryl, Sander, Cindy, Rush, Elizabeth, Karunamurthy, Arivarasan, Massa, Ryan C, Rohatgi, Anjali, Workman, Creg J, Kirkwood, John M, Bruno, Tullia C, Vignali, Dario A A

“…Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective for treatment of advanced melanoma. We designed a trial (NCT03743766)…”
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Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism by Peralta, Ronal M., Xie, Bingxian, Lontos, Konstantinos, Nieves-Rosado, Hector, Spahr, Kellie, Joshi, Supriya, Ford, B. Rhodes, Quann, Kevin, Frisch, Andrew T., Dean, Victoria, Philbin, Mary, Cillo, Anthony R., Gingras, Sebastian, Poholek, Amanda C., Kane, Lawrence P., Rivadeneira, Dayana B., Delgoffe, Greg M.

“…Abstract CD8 + T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent…”
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