Search Results - "Cilliers, Tonie"

The CCR5 and CXCR4 Coreceptors Are Both Used by Human Immunodeficiency Virus Type 1 Primary Isolates from Subtype C by Cilliers, Tonie, Nhlapo, Jabulani, Coetzer, Mia, Orlovic, Dragana, Ketas, Thomas, Olson, William C, Moore, John P, Trkola, Alexandra, Morris, Lynn

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Potent, Broad-Spectrum Inhibition of Human Immunodeficiency Virus Type 1 by the CCR5 Monoclonal Antibody PRO 140 by Trkola, A, Ketas, T J, Nagashima, K A, Zhao, L, Cilliers, T, Morris, L, Moore, J P, Maddon, P J, Olson, W C

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Extreme Genetic Divergence Is Required for Coreceptor Switching in HIV-1 Subtype C by Coetzer, Mia, Nedellec, Rebecca, Cilliers, Tonie, Meyers, Tammy, Morris, Lynn, Mosier, Donald E

“…BACKGROUND:Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear. We have examined…”
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Genetic characteristics of the V3 region associated with CXCR4 usage in HIV-1 subtype C isolates by Coetzer, Mia, Cilliers, Tonie, Ping, Li-Hua, Swanstrom, Ronald, Morris, Lynn

“…CXCR4 coreceptor usage appears to occur less frequently among HIV-1 subtype C viruses. The aim of this study was to investigate the genetic determinants within…”
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Characterization and selection of HIV-1 subtype C isolates for use in vaccine development by Williamson, Carolyn, Morris, Lynn, Maughan, Maureen F, Ping, Li-Hua, Dryga, Sergey A, Thomas, Robin, Reap, Elizabeth A, Cilliers, Tonie, van Harmelen, Joanne, Pascual, Alvaro, Ramjee, Gita, Gray, Glenda, Johnston, Robert, Karim, Salim Abdool, Swanstrom, Ronald

“…HIV-1 genetic diversity among circulating strains presents a major challenge for HIV-1 vaccine development, particularly for developing countries where less…”
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Sensitivity of HIV type 1 subtype C isolates to the entry inhibitor T-20 by Cilliers, Tonie, Patience, Trudy, Pillay, Candice, Papathanasopoulos, Maria, Morris, Lynn

“…T-20 is the first in a new class of antiretroviral drugs targeting the entry stage of the virus life cycle. It is a 36 amino acid peptide that binds to the HR1…”
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Genotypic and phenotypic characterization of viral isolates from HIV-1 subtype C-infected children with slow and rapid disease progression by Choge, Isaac, Cilliers, Tonie, Walker, Polly, Taylor, Natasha, Phoswa, Mary, Meyers, Tammy, Viljoen, Johannes, Violari, Avy, Gray, Glenda, Moore, Penny L, Papathanosopoulos, Maria, Morris, Lynn

“…The genotypes and biological phenotypes of HIV-1 isolates obtained from 40 perinatally infected children in South Africa were analyzed. This included 15…”
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Use of alternate coreceptors on primary cells by two HIV-1 isolates by Cilliers, Tonie, Willey, Samantha, Sullivan, W. Mathew, Patience, Trudy, Pugach, Pavel, Coetzer, Mia, Papathanasopoulos, Maria, Moore, John P., Trkola, Alexandra, Clapham, Paul, Morris, Lynn

“…Two HIV-1 isolates (CM4 and CM9) able to use alternate HIV-1 coreceptors on transfected cell lines were tested for their sensitivity to inhibitors of HIV-1…”
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Longitudinal analysis of HIV type 1 subtype C envelope sequences from South Africa by Coetzer, Mia, Cilliers, Tonie, Papathanasopoulos, Maria, Ramjee, Gita, Karim, Salim Abdool, Williamson, Carolyn, Morris, Lynn

“…The envelope genes of 23 subtype C viral isolates from five individuals with early HIV-1 infection, followed for 2-4 years, were sequenced, analyzed, and…”
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In vitro generation of HIV type 1 subtype C isolates resistant to enfuvirtide by Cilliers, Tonie, Moore, Penny, Coetzer, Mia, Morris, Lynn

“…Enfuvirtide (ENF) is the first in a new class of antiretroviral agents targeting the fusion process of the viral life cycle. ENF is a synthetic 36-amino acid…”
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Predicted genotypic resistance to the novel entry inhibitor, BMS-378806, among HIV-1 isolates of subtypes A to G by MOORE, Penny L, CILLIERS, Tonie, MORRIS, Lynn

“…BMS-378806 targets virus entry by inhibiting the binding of HIV-1 gp120 to the CD4 receptor. Env sequences (n = 1226) of subtypes A-G were analysed to…”
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High specificity of V3 serotyping among human immunodeficiency virus type-1 subtype C infected patients with varying disease status and viral phenotype by Walker, Polly R., Cilliers, Tonie, Choge, Isaac A., Taylor, Natasha, Cohen, Sarah S., Morris, Lynn

“…V3 serotyping is a technique for determining HIV‐1 genetic subtype based on the binding of antibodies from patient sera or plasma to synthetic V3 peptides…”
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CCR5 is the major coreceptor used by HIV-1 subtype C isolates from patients with active tuberculosis by Morris, L, Cilliers, T, Bredell, H, Phoswa, M, Martin, D J

“…Tuberculosis (TB) is the major opportunistic infection of HIV-infected patients in developing countries and is associated with activation of the immune system…”
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Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag by Cave, Eleanor, Weinberg, Marc S, Cilliers, Tonie, Carmona, Sergio, Morris, Lynn, Arbuthnot, Patrick

“…Discovery of sequence-specific silencing by activating the RNA interference (RNAi) pathway has led to exciting new strategies for treating infection with human…”
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Coreceptor usage and biological phenotypes of HIV-1 isolates by Cilliers, Tonie, Morris, Lynn

“…The discovery of chemokine receptors as HIV-1 entry molecules or "coreceptors" has lead to a greater understanding of how HIV-1 infects human cells. This has…”
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Characterization of human immunodeficiency virus type 1 from a previously unexplored region of South Africa with a high HIV prevalence by Bessong, Pascal Obong, Larry Obi, Chikwelu, Cilliers, Tonie, Choge, Isaac, Phoswa, Mary, Pillay, Candice, Papathanasopoulos, Maria, Morris, Lynn

“…HIV prevalence in the Limpopo Province has increased rapidly within the past 10 years, as in other parts of South Africa. Little is known about the genetic and…”
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Full-length genome analysis of HIV-1 subtype C utilizing CXCR4 and intersubtype recombinants isolated in South Africa by Papathanasopoulos, Maria A, Cilliers, Tonie, Morris, Lynn, Mokili, John L, Dowling, William, Birx, Deborah L, McCutchan, Francine E

“…The HIV-1 epidemic in South Africa is largely due to subtype C viruses, which preferentially use CCR5 as a coreceptor for infection. We describe full-length…”
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HIV-1 Subtype A, D, G, AG and unclassified sequences identified in South Africa by Bredell, Helba, Hunt, Gillian, Casteling, Alison, Cilliers, Tonie, Rademeyer, Celia, Coetzer, Mia, Miller, Steven, Johnson, David, Tiemessen, Caroline T, Martin, Desmond J, Williamson, Carolyn, Morris, Lynn

“…HIV-1 subtype C accounts for the vast majority of infections in South Africa. However, increasingly non-C subtypes are being detected. Here we report 10…”
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