Search Results - "Ciliberto, Domenico"

Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study by Tassone, Pierfrancesco, Di Martino, Maria Teresa, Arbitrio, Mariamena, Fiorillo, Lucia, Staropoli, Nicoletta, Ciliberto, Domenico, Cordua, Alessia, Scionti, Francesca, Bertucci, Bernardo, Salvino, Angela, Lopreiato, Mariangela, Thunarf, Fredrik, Cuomo, Onofrio, Zito, Maria Cristina, De Fina, Maria Rosanna, Brescia, Amelia, Gualtieri, Simona, Riillo, Caterina, Manti, Francesco, Caracciolo, Daniele, Barbieri, Vito, Di Paola, Eugenio Donato, Di Francesco, Adele Emanuela, Tagliaferri, Pierosandro

“…We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent…”
Get full text

Identification of ADME genes polymorphic variants linked to trastuzumab-induced cardiotoxicity in breast cancer patients: Case series of mono-institutional experience by Staropoli, Nicoletta, Scionti, Francesca, Farenza, Valentina, Falcone, Federica, Luciano, Francesco, Renne, Maria, Di Martino, Maria Teresa, Ciliberto, Domenico, Tedesco, Ludovica, Crispino, Antonella, Labanca, Caterina, Cucè, Maria, Esposito, Stefania, Agapito, Giuseppe, Cannataro, Mario, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Arbitrio, Mariamena

“…Long-term survival induced by anticancer treatments discloses emerging frailty among breast cancer (BC) survivors. Trastuzumab-induced cardiotoxicity (TIC) is…”
Get full text

Genetic Biomarkers of Sorafenib Response in Patients with Hepatocellular Carcinoma by Giannitrapani, Lydia, Di Gaudio, Francesca, Cervello, Melchiorre, Scionti, Francesca, Ciliberto, Domenico, Staropoli, Nicoletta, Agapito, Giuseppe, Cannataro, Mario, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Seidita, Aurelio, Soresi, Maurizio, Affronti, Marco, Bertino, Gaetano, Russello, Maurizio, Ciriminna, Rosaria, Lino, Claudia, Spinnato, Francesca, Verderame, Francesco, Augello, Giuseppa, Arbitrio, Mariamena

“…The identification of biomarkers for predicting inter-individual sorafenib response variability could allow hepatocellular carcinoma (HCC) patient…”
Get full text

LNA-i-miR-221 activity in colorectal cancer: A reverse translational investigation by Ali, Asad, Grillone, Katia, Ascrizzi, Serena, Caridà, Giulio, Fiorillo, Lucia, Ciliberto, Domenico, Staropoli, Nicoletta, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, Di Martino, Maria Teresa

“…Colorectal cancer (CRC) is one of the most common malignancies and a relevant cause of cancer-related deaths worldwide. Dysregulation of microRNA (miRNA)…”
Get full text

Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients by Botta, Cirino, Barbieri, Vito, Ciliberto, Domenico, Rossi, Antonio, Rocco, Danilo, Addeo, Raffaele, Staropoli, Nicoletta, Pastina, Pierpaolo, Marvaso, Giulia, Martellucci, Ignazio, Guglielmo, Annamaria, Pirtoli, Luigi, Sperlongano, Pasquale, Gridelli, Cesare, Caraglia, Michele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Correale, Pierpaolo

“…Bevacizumab is a humanized anti-VEGF monoclonal antibody able to produce clinical benefit in advanced non-squamous non-small-cell lung cancer (NSCLC) patients…”
Get full text

Pembrolizumab plus lenvatinib in advanced endometrial cancer: case report and systematic review of lung toxicity by Staropoli, Nicoletta, Salvino, Angela, Falcone, Federica, Farenza, Valentina, Costa, Martina, Rossini, Giacomo, Manti, Francesco, Crispino, Antonella, Riillo, Caterina, Ciliberto, Domenico, Arbitrio, Mariamena, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…The optimal strategy for the treatment of recurrent and/or advanced endometrial cancer is still undefined. Recently, despite the lack of any predictive…”
Get full text

Postinfectious Functional Gastrointestinal Disorders in Children: A Multicenter Prospective Study by Pensabene, Licia, MD, PhD, Talarico, Valentina, MD, Concolino, Daniela, MD, Ciliberto, Domenico, MD, Campanozzi, Angelo, MD, Gentile, Teresa, MD, Rutigliano, Vincenzo, MD, Salvatore, Silvia, MD, Staiano, Annamaria, MD, Di Lorenzo, Carlo, MD

“…Objectives To prospectively investigate the occurrence of postinfectious functional gastrointestinal disorders (FGIDs), diagnosed according to the Rome III…”
Get full text

Avelumab treatment in Italian patients with metastatic Merkel cell carcinoma: experience from an expanded access program by Grignani, Giovanni, Chiarion Sileni, Vanna, Pinto, Carmine, Depenni, Roberta, Fazio, Nicola, Galli, Luca, Giuffrida, Dario, Carnaghi, Carlo, Ciliberto, Domenico, Corsi, Domenico C, Queirolo, Paola, Benincasa, Elena, Venturini, Filippo, Fazzi, Gennaro, Costa, Nuno, Ascierto, Paolo Antonio

“…The incidence of Merkel cell carcinoma (MCC), a rare form of skin cancer with a poor prognosis, has increased in Italy in recent decades. Avelumab, an…”
Get full text

Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients by Botta, Cirino, Ciliberto, Domenico, Rossi, Marco, Staropoli, Nicoletta, Cucè, Maria, Galeano, Teresa, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…Despite major therapeutic advancements, multiple myeloma (MM) is still incurable and relapsed/refractory multiple myeloma (RRMM) remains a challenge; the…”
Get full text

First-line systemic treatment for hepatocellular carcinoma: A systematic review and network meta-analysis by Ciliberto, Domenico, Caridà, Giulio, Staropoli, Nicoletta, Romeo, Caterina, Arillotta, Grazia Maria, Napoli, Cristina, Gervasi, Luigia, Luciano, Francesco, Riillo, Caterina, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…The rapid development of novel therapeutic options for advanced hepatocellular carcinoma (aHCC) has generated some uncertainty about the rational choice of the…”
Get full text

Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: A DMET microarray profiling study by Di Martino, Maria Teresa, Arbitrio, Mariamena, Leone, Emanuela, Guzzi, Pietro Hiram, Saveria Rotundo, Maria, Ciliberto, Domenico, Tomaino, Vera, Fabiani, Fernanda, Talarico, Danilo, Sperlongano, Pasquale, Doldo, Patrizia, Cannataro, Mario, Caraglia, Michele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…Recent findings have disclosed the role of UDP-glucuronosyltransferase (UGT) 1A1*28 on the haematological toxicity induced by irinotecan (CPT-11), a drug…”
Get full text

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up by Caraglia, Michele, Correale, Pierpaolo, Giannicola, Rocco, Staropoli, Nicoletta, Botta, Cirino, Pastina, Pierpaolo, Nesci, Antonello, Caporlingua, Nadia, Francini, Edoardo, Ridolfi, Laura, Mini, Enrico, Roviello, Giandomenico, Ciliberto, Domenico, Agostino, Rita Maria, Strangio, Alessandra, Azzarello, Domenico, Nardone, Valerio, Falzea, Antonella, Cappabianca, Salvatore, Bocchetti, Marco, D'Arrigo, Graziella, Tripepi, Giovanni, Tassone, Pierfrancesco, Addeo, Raffaele, Giordano, Antonio, Pirtoli, Luigi, Francini, Guido, Tagliaferri, Pierosandro

“…Background: GOLFIG is a chemo-immunotherapy regimen established in preclinical models that combines gemcitabine + FOLFOX (fluoropyrimidine backbone coupled to…”
Get full text

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine by Correale, Pierpaolo, Botta, Cirino, Staropoli, Nicoletta, Nardone, Valerio, Pastina, Pierpaolo, Ulivieri, Cristina, Gandolfo, Claudia, Baldari, Tatiana Cosima, Lazzi, Stefano, Ciliberto, Domenico, Giannicola, Rocco, Fioravanti, Antonella, Giordano, Antonio, Zappavigna, Silvia, Caraglia, Michele, Tassone, Pierfrancesco, Pirtoli, Luigi, Cusi, Maria Grazia, Tagliaferri, Pierosandro

“…TSPP is an anticancer poly-epitope peptide vaccine to thymidylate synthase, recently investigated in the multi-arm phase Ib TSPP/VAC1 trial. TSPP vaccination…”
Get full text

A Prognostic and Carboplatin Response Predictive Model in Ovarian Cancer: A Mono-Institutional Retrospective Study Based on Clinics and Pharmacogenomics by Staropoli, Nicoletta, Arbitrio, Mariamena, Salvino, Angela, Scionti, Francesca, Ciliberto, Domenico, Ingargiola, Rossana, Labanca, Caterina, Agapito, Giuseppe, Iuliano, Eleonora, Barbieri, Vito, Cucè, Maria, Zuccalà, Valeria, Cannataro, Mario, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…Carboplatin is the cornerstone of ovarian cancer (OC) treatment, while platinum-response, dependent on interindividual variability, is the major prognostic…”
Get full text

Panitumumab Induced Forearm Panniculitis in Two Women With Metastatic Colon Cancer by Domenico, Ciliberto, Antonella, Ierardi, Benedetto, Caroleo, Luigi, Scalise, Antonio, Cimellaro, Lidia, Colangelo, Giuseppe, Spaziano, Gallelli, Luca

“…Panitumumab is an EGFR inhibitor used for the treatment of metastatic colorectal cancer (mCRC), even if its use is related to skin toxicity. We report the…”
Get more information

Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time? by Cucinotto, Iole, Fiorillo, Lucia, Gualtieri, Simona, Arbitrio, Mariamena, Ciliberto, Domenico, Staropoli, Nicoletta, Grimaldi, Anna, Luce, Amalia, Tassone, Pierfrancesco, Caraglia, Michele, Tagliaferri, Pierosandro

“…Nanoparticle albumin bound paclitaxel (nab-paclitaxel) represents the first nanotechnology-based drug in cancer treatment. We discuss the development of this…”
Get full text

Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: A meta-analysis of randomised trials by Ciliberto, Domenico, Botta, Cirino, Correale, Pierpaolo, Rossi, Marco, Caraglia, Michele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…Abstract Background Pancreatic cancer is the fourth leading cause of cancer-related death worldwide. Gemcitabine is the mainstay treatment for advanced…”
Get full text

The Era of PARP inhibitors in ovarian cancer: “Class Action” or not? A systematic review and meta-analysis by Staropoli, Nicoletta, Ciliberto, Domenico, Del Giudice, Teresa, Iuliano, Eleonora, Cucè, Maria, Grillone, Francesco, Salvino, Angela, Barbieri, Vito, Russo, Antonio, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

“…[Display omitted] Carboplatin is the milestone of epithelial ovarian cancer (EOC) treatment, thus response to platinum is the major prognostic factor. Among…”
Get full text

SAT-288 - Genetic biomarkers for sorafenib response in patients with hepatocellular carcinoma by Augello, Giuseppa, Arbitrio, Mariamena, Giannitrapani, Lydia, Scionti, Francesca, Ciliberto, Domenico, Staropoli, Nicoletta, Agapito, Giuseppe, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Soresi, Maurizio, Seidita, Aurelio, Affronti, Marco, Bertino, Gaetano, Russello, Maurizio, Di Gaudio, Francesca, Ciriminna, Rosaria, Spinnato, Francesca, Verderame, Francesco, Cervello, Melchiorre

Get full text

Genetic biomarkers for sorafenib response in patients with hepatocellular carcinoma by Augello, Giuseppa, Arbitrio, Mariamena, Giannitrapani, Lydia, Scionti, Francesca, Ciliberto, Domenico, Staropoli, Nicoletta, Agapito, Giuseppe, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Soresi, Maurizio, Seidita, Aurelio, Affronti, Marco, Bertino, Gaetano, Russello, Maurizio, Di Gaudio, Francesca, Ciriminna, Rosaria, Spinnato, Francesca, Verderame, Francesco, Cervello, Melchiorre

Get full text